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| 1 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 2 | Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo显示文摘BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor metastasis.However,its role in hepatocellular carcinoma(HCC) cells remains unknown.METHODS:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical staining.Apoptosis was evaluated by TUNEL assay.Cell viability and apoptosis were determined by MTT assay and flow cytometry,respectively.Apoptosis-related proteins in SMMC-7721 and HepG2 cells were detected by Western blotting.RESULTS:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of 12-LOX.Baicalein inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent manner.Our in vivo study demonstrated that baicalein also reduced neoplastic nodules.Mechanistically,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of caspase-3.Furthermore,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of 12-LOX.CONCLUSIONS:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment. | Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and Shi-You Chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 20 |
| 3 | Overexpression of p27^(KIP1)induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell line显示文摘AIM We have previously reported that inducibleover-expression of Bak may prolong cell cycle inG1 phase and lead to apoptosis in HCC-9204 cells.This study is to investigate whether p27KIP1playsan important role in this process.METHODS In order to elucidate the exactfunction of p27KIP1in this process,a zinc induciblep27KIP1stable transfectant and transient p27KIP1-GFP fusion transfectant were constructed.Theeffects of inducible,p27KIP1on cell growth,cellcycle arrest and apoptosis were examined in themock,control pMD vector,and pMD-KIP1transfected HCC-9204 cells.RESULTS This p27KIP1-GFP transfectant maytransiently express the fusion gene.The cellgrowth was reduced by 35% at 48 h of p27KIP1induction with zinc treatment as determined bytrypan blue exclusion assay.These differencesremained the same after 72 h of p27KIP1expression,p27KIP1caused cell cycle arrest after24 h of induction,with 40% increase in G1population.Prolonged p27KIP1expression in thiscell line induced apoptotic cell death reflected byTUNEL assay.Fourty-eight h and 72 h of p27KIP1expression showed a characteristic DNA ladder onagarose gel electrophoresis. CONCLUSION Bak may induce cell cycle arrest inG1 phase through upregulating expression ofp27KIP1and subsequently lead to apoptosis inHCC-9204 cells.The p27KIP1-GFP fusion proteincan be transiently expressed in HCC-9204 cells.The inducible p27KIP1-expressing cell line providesa model to assess p27KIP1function. | Jiang Li Xin Ke Yang Xin Xin Yu Meng Liang Ge Wen Liang Wang Jie Zhang Yun De Hou Department of Pathology,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China State Key Laboratory for Molecular Virology and Genetic Engineering,Beijing 100052,China Department of Dermatology,Beijing Hospital,Beijing 100016,China Institute of Radiation Medicine,Beijing 100085,China | 2000 | World Journal of Gastroenterology2000，6，4： | 20 |
| 4 | Sperm DNA damage has a negative effect on early embryonic development following in vitro fertilization显示文摘精子 DNA 损坏作为男不孕的重要 biomarker 被认出。调查这,精子 DNA 损坏被精液的测试和能动精子由联合密度坡度 centrifugation (DGC ) 收获了的精子染色质分散(SCD ) 估计,在 161 的游泳起来联合在 vitro 授精(IVF ) 经历。精液分析和精子 DNA 损坏结果在确实完成了怀孕的夫妇之间被比较。精子 DNA 损坏水平在二个组之间是显著地不同的(P < 0.05 ) 并且否定地与 IVF 结果被相关。逻辑回归分析证实它是为完成临床的怀孕的一个独立预言者。IVF 结果上的精子 DNA 损坏的不同层次的效果也被比较。在白天 3 胚胎质量,胚囊形成率,和培植和怀孕率有重要差别(P < 0.05 ) ,然而并非处于在二个组之间的基本授精率。因此,由 SCD 测量了的精子 DNA 损坏为预言临床的怀孕率追随者 IVF 显得有用。 | Wei-Wei Zheng Ge Song Qi-Ling Wang Shan-Wen Liu Xiao-Li Zhu Shun-Mei Deng An Zhong Yu-Mei Tan Ying Tan | 2018 | Asian Journal of Andrology2018，20，1： | 19 |
| 5 | Atorvastatin reduces myocardial fibrosis in a rat model with post- myocardial infarction heart failure by increasing the matrix metaHoproteinase-2/tissue matrix metalloproteinase inhibitor-2 ratio显示文摘 | AN Zhe YANG Guang HE Yu-quan DONG Ning GE Li-li LI Shu-mei ZHANG Wen-qi | 2013 | Chinese Medical Journal2013，，11： | 17 |
| 6 | Classification and Gradation of Cultivated Land Quality in Bishan County of Chongqing, China显示文摘The conflicts among food security, economic development and ecological protection are the “sticking point” of undeveloped southwestern mountainous areas of China. The objectives of this study are to identify appropriate inte- grated indicators influencing the classification and gradation of cultivated land quality in the southwestern mountainous area of China based on semi-structure interview, and to promote the monitoring of cultivated land quality in this region. Taking Bishan County of Chongqing as a study case, the integrated indicators involve the productivity, protection, ac- ceptability, and stability of cultivated land. The integrated indicators accord with the characteristics of land resources and human preference in southwestern mountainous area of China. In different agricultural zones, we emphasize different indicators, such as emphasizing productivity, stabilization and acceptability in low hilly and plain agricultural integrative zone (LHP-AIZ), protection, productivity and stability in low mountain and hill agro-forestry ecological zone (LMH-AEZ), and acceptability in plain outskirts integrative agricultural zone (PO-IAZ), respectively. The pronounced difference of classification and gradation of cultivated land, regardless of inter-region or intra-region, is observed, with the reducible rank from PO-IAZ, LHP-AIZ to LMH-AEZ. Research results accord with the characteristics of assets management and intensive utilization of cultivated land resources in the southwestern mountainous area of China. Semi-structure interview adequately presents the principal agent of farmers in agricultural land use and rural land market. This method is very effective and feasible to obtain data of the quality of cultivated land in the southwestern mountainous area of China. | SHAO Jing'an GE Xiaofeng WEI Chaofu XIE Deti | 2007 | Chinese Geographical Science2007，17，1： | 10 |
| 7 | Establishing a human pancreatic stem cell line and transplanting induced pancreatic islets to reverse experimental diabetes in rats显示文摘The major obstacle in using pancreatic islet transplantation to cure type I and some type II diabetes is the shortage of the donors. One of ways to overcome such obstacle is to isolate and clone pancreatic stem cells as 'seed cells' and induce their differentiation into functional islets as an abundant trans-plantation source. In this study, a monoclonal human pancreatic stem cell (mhPSC) line was obtained from abortive fetal pancreatic tissues. Pancreatic tissues were taken from abortive fetus by sterile procedures, and digested into single cells and cell clusters with 0.1% type IV collagenase. Cultured in modified glucose-low DMEM with 10% fetal bovine serum (FBS), these single cells and cell clusters adhered to culture dishes, and then primary epidermal-like pancreatic stem cells started to clone. After digesting with 0.25% trypsin and 0.04% EDTA, fibroblasts and other cells were gradually eliminated and epithelioid pancreatic stem cells were gradually purified during generations. Using clone-ring selection, the mhPSCs were obtained. After addition of 10 ng/mL epidermal growth factor (EGF) in cell culture medium, the mhPSCs quickly grew and formed a gravelstone-like monolayer. Continuously proliferated, a mhPSC line, which was derived from a male abortive fetus of 4 months old, has been passed through 50 generations. More than 1×109 mhPSCs were cryo-preserved in liquid nitrogen. Karyotype analysis showed that the chromosome set of the mhPSC line was normal diploid. Immunocytochemistry results demonstrated that the mhPSC line was positive for the pdx1, glucagon, nestin and CK19, and negative for the insulin, CD34, CD44 and CD45 protein expression. RT-PCR revealed further that the mhPSCs expressed transcription factors of the pdx1, glucagon, nestin and CK19. Also, in vitro induced with β-mercaptoethanol, the mhPSCs differentiated into nerve cells that expressed the NF protein. Induced with nicotinamide, the mhPSCs differentiated into functional islet-like clusters, as identified by di-thizone staining, which expressed the transcription factor of the insulin and secreted the insulin and C-peptide. Furthermore, the transplantation of mhPSCs-induced pancreatic islets into the subcapsular region of the kidney in streptozotocin-induced diabetic rats could reduce blood glucose levels and prolong the life time. | XIAO Mei AN LiLong YANG XueYi GE Xin QIAO Hai ZHAO Ting MA XiaoFei FAN JingZhuang ZHU MengYang DOU ZhongYing | 2008 | Science China(Life Sciences)2008，51，9： | 9 |
| 8 | Neogene eolian deposits within the West Qinling Mountains:Climatic and tectonic implications显示文摘The Qinling Mountains constitute a key climate barrier between southern and northern China.Our recent investigations revealed widely spread eolian deposits of Neogene age mantling the piedmont highlands of the intermountain basins within West Qinling.Micro-mammalian fossils dated a 150.2 m section (NL-VI) near Xihe for the late Miocene to Pliocene (~10-4 Ma).Soil micromorphology,grain-size and geochemical analysis consistently define typical loess-soil alternations for the upper (0-66 m) and lower (98-150.2 m) parts of the section,with the middle section (66-98 m) having been affected by episodic slope erosions.These results add important insights to the earlier studies about the widespread eolian deposition in northern China during the Miocene,prior to 8 Ma.They also suggest that the basic configuration of the ridges and inter-ridge basins of West Qinling has already formed by ~10 Ma.The well-preserved eolian deposits are unlikely to support intense substratum deformation and rapid uplift of West Qinling since the late Miocene. | GE JunYi 1,2 & GUO ZhengTang 3 1 State Key Laboratory of Loess and Quaternary Geology (SKLLQG),Institute of Earth Environment,Chinese Academy of Sciences,Xi’an 710075,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Key Laboratory of Cenozoic Geology and Environment,Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029,China | 2010 | Chinese Science Bulletin2010，55，15： | 8 |
| 9 | Inositol Pyrophosphate lnsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis显示文摘The maintenance of cellular phosphate(Pi)homeostasis is of great importance in living organisms.The SPX domain-containing protein 1(SPX1)proteins from both Arabidopsis and rice have been proposed to act as sensors of Pi status.The molecular signal indicating the cellular Pi status and regulating Pi homeostasis in plants,however,remains to be identified,as Pi itself does not bind to the SPX domain.Here,we report the identification of the inositol pyrophosphate lnsP8 as a signaling molecule that regulates Pi homeostasis in Arabidopsis.Polyacrylamide gel electrophoresis profiling of InsPs revealed that lnsP8 level positively correlates with cellular Pi concentration.We demonstrated that the homologs of diphosphoinositol pentaki-sphosphate kinase(PPIP5K),VIH1 and VIH2,function redundantly to synthesize lnsP8,and that the vih1 vih2 double mutant overaccumulates Pi.SPX1 directly interacts with PHR1,the central regulator of Pi starvation responses,to inhibit its function under Pi-replete conditions.However,this interaction is compromised in the vih1 vih2 double mutant,resulting in the constitutive induction of Pi starvation-induced genes,indicating that plant cells cannot sense cellular Pi status without lnsP8.Furthermore,we showed that lnsP8 could directly bind to the SPX domain of SPX1 and is essential for the interaction between SPX1 and PHR1.Collectively,our study suggests that lnsP8 is the intracellular Pi signaling molecule serving as the ligand of SPX1 for controlling Pi homeostasis in plants. | Jinsong Dong Guojie Ma Liqian Sui Mengwei Wei Viswanathan Satheesh Ruyue Zhang Shenghong Ge Jinkai Li Tong-En Zhang Christopher Wittwer Henning JJessen Huiming Zhang Guo-Yong An Dai-Yin Chao Dong Liu Mingguang Lei | 2019 | Molecular Plant2019，12，11： | 8 |
| 10 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 11 | Retrograde approach for the recanalization of coronary chronic total occlusion: preliminary experience of a single center显示文摘为开运河不戏剧性地有的长期的全部的吸藏(CTO ) 的 antegrade 途径的成功率增加了的背景,特别在复杂 CTO 子集。retrograde 技术可以保持大诺言。这份报告试图描述我们的经验后退为 CTO 的开运河,集中于它的安全和可行性。我们识别了在 CTO 经历了 revascularization 与的 42 个病人的方法后退在我们的 center.Results 的 2009 年 11 月的从 2005 年 7 月的途径三种策略被使用:作为主要策略(50.0%) 后退,在 antegrade 失败(26.2%) 以后立即后退并且重复在以前的 antegrade 失败(23.8%) 以后的过程。氏族的担保更经常被用作 retrograde 存取线路(92.9%) 。全面成功率是 88.1% 。在病人与成功后退电线十字路口担保隧道到 CTO 的远侧的帽子,开运河的成功率是 94.1% 。在有失败到的病人穿过担保,成功率是 62.5% 。八种不同类型后退技术被使用:吻的电线技术(35.3%),套住的电线和套住的反向的电线技术(17.6%),后端汽球和 microcatherer 颠倒技术(14.7%),控制 antegrade 并且后退追踪的 subintimal (大车)技术(8.8%),反向的大车和修改颠倒运技术(8.8%),后退电线十字路口技术(2.9%)。有 4 复杂并发症没有在里面医院,发生了主要不利心脏的事件(向) 。在里面医院向是 7.7% 。所有他们是 non-Q 挥动心肌的梗塞。没有死亡的盒子或指向 retrograde 途径能是的容器 revascularization,任何一个外科或 percutaneous.Conclusions 为在复杂 CTO 增加开运河的成功率的一个有效工具。保证由富有经验的操作员处理的途径,小心的盒子选择和设备的成功和安全是必要的。 | GE Lei QIAN Ju-ying LIU Xue-bo QIN Qing CUI Shan-jing YAO Kang SHEN Li MA Jian-ying HUANG Dong XU Shi-kun ZHANG Feng WANG Xiang-fei WANG Qi-bing FAN Bing YAN Yan FENG Qi WANG Hao SHEN An ZHU Ming-hui GE Jun-bo | 2010 | Chinese Medical Journal2010，，7： | 7 |
| 12 | Research on forced gas draining from coal seams by surface well drilling显示文摘表面钻在 Luling 煤矿被执行,在 Huaibei,到弄短为煤气的排干要求的时期。试验性的学习被设计由高效地从上面的保护的层排干气体减少煤气的控制的费用。结构的提讯和经由表面钻的压力地势的技术原则被讨论。从试用的结果显示出在 10 个月的一个时期上从表面系统排干的那气体。全部的数量镇定气体是 2.484 亿 m3。排干的气体发生在三个阶段:一个生长时期;最大的煤气的生产的一个时期;并且一个变细时期。最大的煤气的生产的时期持续了 4 个月。在期间这次,甲烷集中从 60% ~ 90%,平均排干率是 10.6 m3/min。与排干它的另外的方法结合了是可能的从中间的煤缝接组排干 70.6% 气体。掉到 5.2 m3/ton 的剩余气体的数量,和剩余气体的压力掉到 0.53 MPa,从而在中间的煤缝接消除爆发危险组织。影响由表面钻排干的压力消除气体的因素被分析。 | Wu Dongmei Wang Haifeng Ge Chungui An Fenghua | 2011 | Mining Science and Technology2011，21，2： | 7 |
| 13 | NUMERICAL STUDIES ON RESONANT AND ENHANCEMENT EFFECTS FOR COUPLING OF MICROWAVE PULSES INTO NARROW SLOTS显示文摘In this paper, modifications to the finite-difference time-domain(FD-TD) method for modeling microwave pulse coupling into a slot, which is much narrower than one conventional FD-TD cell, are discussed. The coupling process of microwave pulse into a slot is studied by using the modified FD-TD method, and the dependence of microwave coupling on slot sizes, the carrier frequencies and the polarization directions of the incident waves is analysed. Resonant and enhancement effects which occur in this process are observed. The condition at which the resonant effect takes place is also presented. | Wang Jianguo Yu Hanqing Liu Guozhi Chen Yusheng Fan Ruyu (Northwest Institute of Nuclear Technology, Branch 15, P. O. Box 69, Xi’an 710024)Ge Debiao(Department of Physics, Xidian University, Xi’an 710071) | 1998 | Journal of Electronics(China)1998，15，2： | 6 |
| 14 | Lymphangiogenic and angiogenic microvessel density in human primary sporadic colorectal carcinoma显示文摘AIM: To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma (SCRC) and their relationship to metastasis and prognosis. METHODS: The lymphatic vessel density (LVD) and microvessel density (MVD) in tumor tissue obtained from 132 patients with primary SCRC, including 74 with metastases and 58 without metastases, were evaluated by immunohistochemistry using antibodies directed against D2-40 and von Willebrand factor (vWF).RESULTS: (1) The lymphatic vessels and microvessels at central portions of SCRC often had a reticular architecture with numerous tiny and ill-defined lumina, while those at tumor borders had large and open lumina. The LVD and MVD were both obviously higher in colorectal cancer patients with metastases than in those without (P < 0.001). (2) For each one lymphatic vessel increased, there was a 1.45-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of LVD in predicting metastasis or non-metastasis in SCRC were 71.62% and 56.90%, respectively, and the corresponding LVD was 5. For each one microvessel increased, there was a 1.11-fold increase in the risk of metastasis in SCRC. The specificity and sensitivity of MVD were 66.22% and 51.72%, respectively. (3) Double labeling immunohistochemistry showed D2-40 immunoreactivity to be specific for lymphatic vessels. (4) Univariate analysis indicated that high LVD, high MVD, as well as co-accounting of high LVD and high MVD were associated with patient's poor disease-free survival (Puni < 0.05); multivariate analysis indicated that co-accounting of LVD and MVD was an independent prognostic factor of colorectal cancer. CONCLUSION: D2-40 is a new specific antibody for lymphatic endothelial cells. Lymphogenesis and angiogenesis are commonly seen in SCRC, especially at tumor borders. The detection of LVD and MVD at tumor borders may be useful in predicting metastasis and prognosis in patients with SCRC, and, in particular, co-accounting of LVD and MVD might be a useful prognostic factor in SCRC. | Ge Yan, Xiao-Yan Zhou, San-Jun Cai, Gui-Hong Zhang, Jun-Jie Peng, Xiang Du, Department of Pathology, Cancer Hospital of Fudan University Department of Oncology, Shanghai Medical College, Fudan University Colorectal Cancer Center, Fudan University, 270 Dong’an Road, Shanghai 200032, China | 2008 | World Journal of Gastroenterology2008，14，1： | 6 |
| 15 | Reliability design optimization of composite structures based on PSO together with FEA显示文摘The present work aims to develop a method for reliability-based optimum design of composite structures. A procedure combining particle swarm optimization (PSO) and finite element analysis (FEA) has been proposed. Numerical examples for the reliability design optimization (RDO) of a laminate and a composite cylindrical shell are worked out to demonstrate the effectiveness of the method. Then a design for composite pressure vessels is studied. The advantages and necessity of RDO over the conventional equi-strength design are addressed. Examples show that the proposed method has good stability and is efficient in dealing with the probabilistic optimal design of composite structures. It may serve as an effective tool to optimize other complicated structures with uncertainties. | Chen Jianqiao Tang Yuanfu Ge Rui An Qunli Guo Xiwei | 2013 | Chinese Journal of Aeronautics2013，26，2： | 6 |
| 16 | Review of Digital Elevation Model (DEM) Based Research on China Loess Plateau显示文摘The Loess Plateau is one of the hot research areas for its specific geographical features. In resent years, with the establishment of national multi-scale DEMs and the perfection of DEM based digital terrain analysis methods, new thoughts and methodologies have been constructed for the Loess Plateau research. This paper introduces the characteristics of DEM data, analyses the development stages of DEM applied in the Loess Plateau research, and discusses its further possible research direction. More discussions are focused on slope spectrum and its concept, as well as the significance in the Loess Plateau research. | Tang Guo'an Ge Shanshan Li Fayuan Zhou Jieyu | 2005 | Journal of Mountain Science2005，2，3： | 5 |
| 17 | P ill C am colon capsule endoscopy versus conventional colonoscopy for the detection of severity and extent of ulcerative colitis显示文摘 | Chen An Ye Yun Jie Gao Zhi Zheng Ge Jun Dai Xiao Bo Li Han Bing Xue Zhi Hua Ran Yun Jia Zhao | 2013 | Journal of Digestive Diseases2013，，3： | 4 |
| 18 | Age assignment and geological significance of the “Budate Group” in the Hailar Basin显示文摘Age and nature of the Budate Group in the Hailar Basin are of great significance in studying the evolution of the Hailar Basin and the Xing'an-Mongolian Orogenic Belt(XMOB).Zircon U-Pb ages of eight volcanic rocks from the Budate Group and two basement granites in the Hailar Basin were reported in this study.The dating results indicated that the formation of these volcanic rocks was consistent with the emplacement of Late Paleozoic basement granite in age(356-290 Ma),i.e.,Early Carboniferous to Early Permian rather than Early Mesozoic.Combined with regional geology,it was concluded that the Budate Group is the component of the basement of the Hailar Basin,and these volcanic rocks were formed at an active continental margin,which is related to the closure of the Hegen Mountains suture zone.The captured Neoproterozoic zircons(814-873 Ma) were probably derived from the Neoproterozoic basement materials in the Ergun Block,implying the close genetic relationships between the Ergun Block(including the Hailar Basin) and the Siberian Block. | MENG Qi'An WAN ChuanBiao ZHU DeFeng ZHANG YanLong GE WenChun WU FuYuan | 2013 | Science China Earth Sciences2013，56，6： | 4 |
| 19 | OPTIMIZATION OF TRANSIENT FEEDING TO PARALLEL-PLATE TRANSMISSION LINES FROM COAXIAL LINE显示文摘The transient feeding to parallel-plate transmission lines from coaxial line is optimized by using the Finite-Difference Time-Domain (FDTD) method and a simple FDTD feed model. Observing the reflected voltages, this letter presents the optimal feeding position and ratio of width to height for a given input impedance of the coaxial line. | Tian Chunming Wang Jianguo Meng Fenxia Zhang Maoyu Ge Debiao(Department of Physics, Xidian University, Xi’an 710071) (Northwest Institute of Nuclear Technology, P. O. Box 69-15, Xi’an 710024) | 2001 | Journal of Electronics(China)2001，18，3： | 4 |
| 20 | Broadband quasi-phase matching in a MgO:PPLN thin film显示文摘Future quantum information networks operated on telecom channels require qubit transfer between different wavelengths while preserving quantum coherence and entanglement. Qubit transfer is a nonlinear optical process,but currently the types of atoms used for quantum information processing and storage are limited by the narrow bandwidth of upconversion available. Here we present the first experimental demonstration of broadband and high-efficiency quasi-phase matching second-harmonic generation(SHG) in a chip-scale periodically poled lithium niobate thin film. We achieve a large bandwidth of up to 2 THz for SHG by satisfying quasi-phase matching and group-velocity matching simultaneously. Furthermore, by changing the film thickness, the central wavelength of the quasi-phase matching SHG bandwidth can be modulated from 2.70 μm to 1.44 μm. The reconfigurable quasi-phase matching lithium niobate thin film provides a significant on-chip integrated platform for photonics and quantum optics. | LICHENG GE YUPING CHEN HAOWEI JIANG GUANGZHEN LI BING ZHU YI'AN LIU XIANFENG CHEN | 2018 | Photonics Research2018，6，10： | 3 |
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