|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | P-glyeopmtein andmultidrug resistance显示文摘 | Gottesman MM Pastan L Ambudkar SV | 1996 | Curr Opin Genet Dev1996，6，5： | 1 |
| 3 | Biochemical, cellular and pharmaxological aspects of the multidrug transporter显示文摘 | Ambudkar SV Dey S Hrycyrna CA | 1999 | Annu Rev Pharmacol Tarical1999，39，： | 1 |
| 4 | Biochendcal,cellular, and pharmacological aspects of the multidrug transporter 显示文摘 | Ambudkar SV Dey S Hrycyna CA | 1999 | Annu Rev Pharmacol Toxicol1999，39，： | 1 |
| 5 | P-glycoprotein and multidrug resistance显示文摘 | Gottesman MM Pastan L Ambudkar SV | 1996 | Curr Opin Genet Dev1996，6，5： | 1 |
| 6 | Biochemical,cellular,and Pharmacological aspects of the multidrug transporter显示文摘 | AMBUDKAR S V DEY S HRYCYNA C A | 1999 | Annu Rev Pharmacol Toxicol1999，39，： | 1 |
| 7 | The Mechanism of Action of Multidrug-Resistance-Linked P-Glycoprotein显示文摘 | Zuben E. Sauna Melissa M. Smith Marianna Müller Kathleen M. Kerr Suresh V. Ambudkar | 2001 | Journal of Bioenergetics and Biomembranes2001，，： | 1 |
| 8 | Organization and function of TRPC chan- nelosomes 显示文摘 | Ambudkar IS Ong HL | 2007 | Pflugers Arch2007，455，2： | 1 |
| 9 | Characteristics of a store-operated calcium-permeable channel:sarcoendoplasmic reticulum calcium pump function controls channel gating显示文摘 | Liu X Ambudkar IS | 2001 | J Biol Chem2001，276，29： | 1 |
| 10 | Mechanism of action of human P- glycoprotein ATPase activity, photochemical cleavage during a catalytic transition state using orthovanadate reveals cross - talk between the two sites 显示文摘 | Hrycyna C A Ramachandra M Ambudkar S V | 1998 | J Biol Cbem1998，273，16： | 1 |
| 11 | P-glycoprotein from genomics to mechanism 显示文摘 | Ambudkar S V Kimchi-Sarfaty C Sauna Z E | 2003 | Oncogene2003，22，47： | 1 |
| 12 | Ca 2+ signaling and regulation of fluid secretion in salivary gland acinar cells显示文摘 | Indu S. Ambudkar | 2014 | Cell Calcium2014，，： | 1 |
| 13 | Characterization of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein显示文摘 | Ambudkar SV | 2001 | J Biol Chem2001，276，11： | 1 |
| 14 | P-glycoprotein and multidrug resistance显示文摘 | Gottesman MM Pastan I Ambudkar SV | 1996 | Curr Opin Genet Dev1996，6，5： | 1 |
| 15 | P-glycoprotein:from genomics to mechanism显示文摘 | Ambudkar SV Kimchi-Sarfaty C Sauna ZE | 2003 | Oncogene2003，22，47： | 1 |
| 16 | TRPCh the link between functionally distinct store-operated calcium channels 显示文摘 | Ambudkar IS Ong HL Liu X | 2007 | Cell Calcium2007，42，2： | 1 |
| 17 | The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib andIc显示文摘 | Chen SY Pan CJ Nandigama K Mansfield BC Ambudkar SV Chou JY | 2008 | FASEB J2008，22，7： | 1 |
| 18 | The power of the pump: mecha- nisms of action of P-glycoprotein (ABCB1) 显示文摘 | Ambudkar SV Kim IW Sauna ZE | 2006 | Eur J Pharm Set2006，27，5： | 1 |
| 19 | Genomics and the mechanism of P-glycoprotein (ABCB1) 显示文摘 | Sauna ZE Kim IW Ambudkar SV | 2007 | J Bioenerg Biomembr2007，39，56： | 1 |
| 20 | Distinct mechanisms of i oscillations in HSY and HSG cells: role of Ca^2+ influx and internal Ca^2+ store recycling 显示文摘 | LIU X LIAO D AMBUDKAR IS | 2001 | J Membr Biol2001，181，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员