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| 1 | Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways显示文摘Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways. | Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid | 2017 | Chinese Journal of Natural Medicines2017，15，7： | 2 |
| 2 | The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase 显示文摘 | Rosengren E Aman P Thelin S | 1997 | FEBS Lett1997，417，： | 1 |
| 3 | Diagnosis of choledocholithiasis and bile duct stenosis by magnetic resonance cholangiogram显示文摘 | Hussein FM Alsumait B Aman S | 2002 | Australas Radiol2002，46，1： | 1 |
| 4 | Study of the impact of riveting sequence, rivet pitch, and gap between sheets on the quality of riveted lap joints u- sing finite element method显示文摘 | AMAN F CHERAGHI S H KRISHNAN K K | 2013 | International Journal of Ad- vanced Manufacturing Technology2013，67，： | 1 |
| 5 | Land mobile station for ETS-VIII mobile satellite communica- tions experiments显示文摘 | AMANE M SHIN-LCHI Y MASAKISTANDAR S | 2003 | Journal of the National Institute of Information and Communications Ttechnology2003，50，3： | 1 |
| 6 | Multiplex PCR for rapid diagnosis of tuberculous meningitis显示文摘 | Kusum S Aman S Pallab R | 2011 | J Neurol2011，258，： | 1 |
| 7 | The value of synovial fluid analysis in the assessment of knee joint destruction in arthritis in a three-year follow up study显示文摘 | Aman S Risteli J Luukkainen R | | 0，，9： | 1 |
| 8 | Optimizing Agrobacterium -mediated transformation of grapevine显示文摘 | LI Z T DHEKNEY S DUTT M AMAN V M TATTERSALL I KELLEY K T GRAY D J | 2006 | In Vitro Cellular & Developmental Biology - Plant2006，42，3： | 1 |
| 9 | Enhanced pro- duction of cellulose degrading CMCase by newly isolated strain of Aspergillus versicolor 显示文摘 | QAISAR S ZOHRA R AMAN A | 2014 | Carbohydrate Polymers2014，104，15： | 1 |
| 10 | Multiplex PCR for rapid diagnosis of tuberculous meningitis显示文摘 | Kusum S Aman S Pallab R | 2011 | J Neurol2011，258，10： | 1 |
| 11 | Multiplex PCR for rapid diagnosis of tuberculous meningitis显示文摘 | Kusum S Aman S Pallab R | | 0，，10： | 1 |
| 12 | Relationship between the chemical properties of bitumens and their colloidal properties in water显示文摘 | MARTINE S BERNARD S AMANE J | 1998 | Fuel1998，77，4： | 1 |
| 13 | Prediction of disease progression in early rheumatoid arthritis by I CTP,RF and CRP: a comparative 3-year follow-up study 显示文摘 | Aman S Paimela L Leirisalo-Repo M | 2000 | Rheumatology2000，39，： | 1 |
| 14 | Isolation and chemical characterization of water-soluble arabinoxylans in rye grain显示文摘 | Bengtsson S Aman P | 1990 | Carbohydrate Polymers1990，12，3： | 1 |
| 15 | Feasbility of chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering显示文摘 | Amane S Iwasaki N Majima T | 2005 | Biomaterials2005，26，6： | 1 |
| 16 | Morphology, thermal re- sponse and anti-ablation performance of 3D-four directional pitch-based carbon/carbon composites 显示文摘 | aman W Li K Z Ikram S | 2012 | Corrosion science2012，61，： | 1 |
| 17 | Dietary L-carnitine increase plasma insulin-like growth factor-Ⅰ concentration in chickens fed a diet with adequate dietary protein level 显示文摘 | Kita K Kato S Aman Yaman M Okumura J Yokota H | 2002 | British Poultry Science2002，43，： | 1 |
| 18 | Premenstrual syndrome: Frequency and severity in young college girls 显示文摘 | TABASSUM S AFRIDI B AMAN Z | 2005 | J Pak Med Assoc2005，55，12： | 1 |
| 19 | Isolation and chemical characterization of water-soluble arabinoxylans in rye grain显示文摘 | Bengtsson S Aman P | 1990 | Carbohydrate Polymers1990，12，3： | 1 |
| 20 | An anatomical study of CI-C2 pediele显示文摘 | Naderi S Aman C Guvenecer M eta/ | 2004 | J Neurosury Spine2004，3，： | 1 |
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