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	题名	作者	年代	出处	被引量
1	N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.	Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea	2008	World Journal of Gastroenterology2008，14，18：	2
2	One decade of salivary proteomics: Currentapproaches and outstanding challenges显示文摘	AMADO F M L FERREIRA R P VITORINAR	2013	ClinicalBiochemistry2013，46，6：	1
3	DCT-domain watermarking techniques for still images:Detector performance analysis and a new structure显示文摘	J R Hernández M Amado Femando Pérez-González	2000	IEEE Trans on Image-Processing2000，9，1：	1
4	In vitro digestibility and colonic fermentation of aleurone from wheat 显示文摘	Amrein T M Granicher P Arrigoni E Amado R	2003	Lebensmittel-Wissenschaft and Technologie2003，36，：	1
5	Evaluation of two bacteriocin-producing probiotic lactic acid bacteria as inoculants for controlling Listeria monocytogenes in grass and maize silages显示文摘	Amado I R Fuci觡os C Fajardo P	2012	Animal Feed Science&Technology2012，175，34：	1
6	Influence of thermal processing conditions on aerylamide genera- tion and browning in a potato model system显示文摘	Amrein T M Limacher C P Amado R	2006	Journal of Agricultural and Food Chemistry2006，54，16：	1
7	DCTdomain Watermarking Techniques for Still Images:Detector Performance Analysis and a New Structure显示文摘	Hernández J R Amado M Pérez-González F	2000	IEEE Trans on Image Processing2000，9，1：	1
8	Does orthostatic hypertension predict the occurrence of nocturnal arterial hypertension in the elderly patient? 显示文摘	Carmona J Amado P Vasconcelos N	2003	Rev Port Cardiol2003，22，5：	1
9	Structure, e:ression profile and subceIlular localisation of four different sucrose synthase genes from barley显示文摘	Sicilia C B Amado S H Melendi G P et ol	2011	Planta2011，234，：	1
10	Detection and characterization of hydroxyl radical adducts by mass spectrometry显示文摘	Domingues P Domingues MR Amado FM	2001	J Am Soc Mass Spectrom2001，12，：	1
11	Challenges for performance assessment and improvement in primary health care: The case of the Potluguese health eentres显示文摘	Amado C A Santos S P	2009	Health Poliey2009，91，1：	1
12	DCT-domain watermarking technique for still images:dector performance analysis and a new structure 显示文摘	AMADO M GONZALEZ F P	2000	IEE Transactions on Image Procession2000，9，1：	1
13	Morning rise, morning surge and daytime variability of blood pressure and cardiovascular target organ damage= a cross sectional study in 743 subjects显示文摘	Polonia J Amado P Barbosa L	2005	RevPort Cardiol2005，24，1：	1
14	Integrating the data envelopment analysis and the balanced scorecard approaches for enhanced performance assessment显示文摘	AMADO A F SANTOS S P MARQUES P M	2012	Omega2012，，40：	1
15	Long-term (four years) follow-up of patients with treated nocturnal hypertension assessed by ambulatory blood pressure monitoring显示文摘	Carmona J Amado P vasconcelos N	2001	Rev Port Cardiol2001，20，2：	1
16	DCT-domain watermarking techniques for still image:detector performance analysis and a new structure显示文摘	Hernandez J R Amado M Genzalez F P	2000	IEEE Trans on Image Processing2000，9，1：	1
17	Facilitation and transfer with narrative thematic versions of the THOG task显示文摘	NeedhaW P & Amado C A	1995	Psychological Research1995，，：	1
18	Structure, expression profile and subcellular localisation of four dif- ferent sucrose synthase genes from barley 显示文摘	Sicilia C B Amado S H Melendi G P	2011	Planta2011，234，2：	1
19	Contrast-enhancement multidetector compu ted tomography viability imaging after myocardial infarction characterization of myocyte death, microvascular obstruction and chronic scar显示文摘	Lardo A C Cordeiro M A S Silva C Amado L C George R T Saliaris A P	2006	Circulation2006，113，：	1
20	Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction显示文摘	Amado L C Saliaris A P Schuleri K H	2005	Proc Natl Acad Sci USA2005，102，11：	1

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