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| 1 | Cerebrospinal fluid phosphorylated tau,visinin-like protein-1,and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease显示文摘Background:Visinin-like protein-1(VILIP-1)and chitinase-3-like protein 1(CHI3L1 or YKL-40)in cerebrospinal fluid(CSF)are newly discovered markers indicating neuronal damage and microglial activation,respectively.Phosphorylated tau(p-tau)reflects the neuropathology of Alzheimer’s disease(AD)and is useful as diagnostic markers for AD.However,it is unknown whether these biomarkers have similar or complementary information in AD.Methods:We stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative(ADNI)database into cognitively normal(CN),stable mild cognitive impairment(sMCI),progressive MCI(pMCI),and dementia due to AD.Analysis of covariance(ANOVA)and chi-square analyses,Spearman correlation,and logistic regression models were performed to test the demographic,associations between biomarkers,and diagnostic accuracies,respectively.Linear mixed-effects models were used to evaluate the effects of CSF amyloid-β(Aβ)on above biomarkers within diagnostic groups,the combination of diagnostic group and Aβstatus as predictor,and CSF biomarkers as predictors of AD features,including cognition measured by Mini–Mental State Examination(MMSE)and brain structure and white matter hyperintensity(WMH)measured by magnetic resonance imaging(MRI).Results:P-tau,VILIP-1,and YKL-40 were all predictors of AD diagnosis,but combinations of biomarkers did not improve the diagnostic accuracy(AUC 0.924 for p-tau,VILIP-1,and YKL-40)compared to p-tau(AUC 0.922).P-tau and VILIP-1 were highly correlated(r=0.639,p<0.001)and strongly associated with Aβpathology across clinical stages of AD,while YKL-40 was correlated with Aβpathology in CN and AD groups.VILIP-1 was associated with acceleration of cognitive decline,hippocampal atrophy,and expansion of ventricles in longitudinal analyses.YKL-40 was associated with hippocampal atrophy at baseline and follow-up,while p-tau was only associated with worsening WMH at baseline.Conclusions:CSF levels of p-tau,VILIP-1,and YKL-40 may have utility for discriminating between cognitively normal subjects and patients with AD.Increased levels of both VILIP-1 and YKL-40 may be associated with disease degeneration.These CSF biomarkers should be considered for future assessment in the characterization of the natural history of AD. | Hua Zhang Kok Pin Ng Joseph Therriault Min Su Kang Tharick APascoal Pedro Rosa-Neto Serge Gauthier the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 2 | MR影像体素形态学的阿尔茨海默病自动分类方法显示文摘为了确定轻度认知功能障碍(MCI)与阿尔茨海默病(AD)患者发生萎缩的重要脑区,实现正常老年人(NC)对照组、MCI与AD三组人群的分类,选择了178名被试的脑部MR影像,利用体素形态学与方差分析方法,考察NC,MCI与AD三组人群的MR影像中灰质体积差异;然后,采用递归特征消去法对特征进行降维;最后,利用线性支持向量机对这3种人群进行分类.实验结果表明,MCI组与NC组、MCI组与AD组、AD组与NC组的平均分类准确率分别为(90.2±1.3)%,(74.7±0.9)%,100%.对分类产生重要影响的脑区包括海马、海马旁回、杏仁核、梭状回和嗅皮层等.所提方法不仅能有效揭示NC,MCI,AD三组人群的脑灰质差异,阐明MCI患者与AD患者脑区发生萎缩的过程与特性,而且能准确区分这3组人群,具有显著的临床应用价值. | 郭圣文 池敏越 岑桂英 匡翠立 牛传筱 赖春任 吴效明 The Alzheimer's Disease Neuroimaging Initiative (ADNI) | 2015 | 东南大学学报(自然科学版)2015，45，2： | 4 |
| 3 | Alzheimer's disease progression model based on integrated biomarkers and clinical measures显示文摘 | Yue QIU Liang LI Tian-yan ZHOU Wei LU Alzheimer's Disease Neuroimaging Initiative | 2014 | Acta Pharmacologica Sinica2014，35，9： | 2 |
| 4 | Aberrant functional connectivity network in subjective memory complaint individuals relates to pathological biomarkers显示文摘Background:Individuals with subjective memory complaints(SMC)feature a higher risk of cognitive decline and clinical progression of Alzheimer’s disease(AD).However,the pathological mechanism underlying SMC remains unclear.We aimed to assess the intrinsic connectivity network and its relationship with AD-related pathologies in SMC individuals.Methods:We included 44 SMC individuals and 40 normal controls who underwent both resting-state functional MRI and positron emission tomography(PET).Based on graph theory approaches,we detected local and global functional connectivity across the whole brain by using degree centrality(DC)and eigenvector centrality(EC)respectively.Additionally,we analyzed amyloid deposition and tauopathy via florbetapir-PET imaging and cerebrospinal fluid(CSF)data.The voxel-wise two-sample T-test analysis was used to examine between-group differences in the intrinsic functional network and cerebral amyloid deposition.Then,we correlated these network metrics with pathological results.Results:The SMC individuals showed higher DC in the bilateral hippocampus(HP)and left fusiform gyrus and lower DC in the inferior parietal region than controls.Across all subjects,the DC of the bilateral HP and left fusiform gyrus was positively associated with total tau and phosphorylated tau181.However,no significant between-group difference existed in EC and cerebral amyloid deposition.Conclusion:We found impaired local,but not global,intrinsic connectivity networks in SMC individuals.Given the relationships between DC value and tau level,we hypothesized that functional changes in SMC individuals might relate to pathological biomarkers. | Kaicheng Li Xiao Luo Qingze Zeng Yeerfan Jiaerken Xiaojun Xu Peiyu Huang Zhujing Shen Jingjing Xu Chao Wang Jiong Zhou Min-Ming Zhang the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 2 |
| 5 | An English translation of Alzheimer' s 1907 paper, 'Uber eine eigen artige Erkankung der Hirnrinde'显示文摘 | Stelzmann RA Schnitzlein HN | 1995 | Clin Anat1995，8，： | 1 |
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| 15 | MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults 显示文摘 | Dickerson BC Wolk DA Alzheimer' s Disease Neuroimaging Initiative | 2012 | Neurology2012，78，2： | 1 |
| 16 | A systematic review and analysis显示文摘 | Chan KY Wang W Wu JJ Epidemiology of Alzheimer' s disease andother forms of dementia in China 1990-2010 | 2013 | Lancet2013，381，9882： | 1 |
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| 20 | Vitamin E and donepezil for the treatment of mild cognitive impairment显示文摘 | Petersen RC Thomas RG Grundman M Bennett D Doody R Ferris S Galasko D Jin S Kaye J Levey A Pfeiffer E Sano M van Dyck CH Thal LJ Alzheimer's Disease Cooperative Study Group | | 0，，23： | 1 |
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