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63篇 您的检索式：作者名="Alvarez CA"

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	题名	作者	年代	出处	被引量
1	MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults显示文摘AIM:To evaluate the association between Helicobacter pylori(H.pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability(MSI).METHODS:The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction(MSPPCR) in gastric biopsy samples from uninfected or H.pylori-infected children(n = 50),from adults with chronic gastritis(n = 97) and from adults with gastric cancer(n = 92).MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene(β actin).MSI analysis was performed by screening MSI markers at 4 loci(Bat-25,Bat-26,D17S250 and D2S123) with PCR;PCR products were analysed by single strand conformation polymorphism followed by silver staining.Statistical analyses were performed with either the χ 2 test with Yates continuity correction or Fisher's exact test,and statistical significance for expression analysis was assessed using an unpaired Student's t-test.RESULTS:Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children,regardless of H.pylori infection status.The MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with H.pylori infection(P < 0.05);this region was methylated in 66% of gastric cancer patients,and the difference in the percentage of methylated samples between these patients and those from H.pylori-infected chronic gastritis patients was statistically significant(P < 0.05).MLH1 methylation frequencies among H.pylori-infected and non-infected chronic gastritis adult patients were 13% and 7%,respectively.We observed methylation of the MLH1 promoter(39%) and increased MSI levels(68%) in samples from gastric cancer patients in comparison to samples from H.pylori-infected adult chronic gastritis patients(P < 0.001 and P < 0.01,respectively).The frequency of promoter methylation for both genes was higher in gastric cancer samples than in H.pylori-positive chronic gastritis samples(P < 0.05).The levels of MLH1 and MGMT mRNA were significantly reduced in chronic gastritis samples that were also hypermethylated(P < 0.01).CONCLUSION:In summary,MGMT and MLH1 methylation did not occur in earlier-stage H.pylori infections and thus might depend on the duration of infection.	Marisa C Alvarez Juliana C Santos Nathália Maniezzo Marcelo S Ladeira Artur LC da Silva Isabel CA Scaletsky José Pedrazzoli Jr Marcelo L Ribeiro	2013	World Journal of Gastroenterology2013，19，20：	5
2	Intra-arterial administration of microbubbles and continuous 2-MHz ultrasound insonation to enhance intra-arterial thrombolysis显示文摘	Ribo M Molina CA Alvarez B	2010	J Neuroimaging2010，20，3：	1
3	Predicting out of In- tensive Care Unit Cardiopulmonary Arrest or Death Using E- lectronic Medical Record Data 显示文摘	Alvarez CA Clark CA Zhang S	2013	BMC Med Inform Decis Mak2013，，13：	1
4	Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator-treated patients显示文摘	Alvarez - sabin J Molina CA Montaner J	2003	Stroke2003，34，5：	1
5	Effects of admission hyper-glycemia on stroke outcome in recombinant tissue plasminogen activatortreated patients显示文摘	Alvarez SJ Molina CA Moteaner J	2003	Stroke2003，34，5：	1
6	Intra-arterial administration of microbubbles and continuous 2-MHz ultrasound insonation to enhance intra-arterial thrombolysis显示文摘	Ribo M Molina CA Alvarez B	2010	J Neuroimaging2010，20，3：	1
7	CD5 negative mantle cell lymphoma: a different clinical entity? 显示文摘	Alvarez - Argote J Bauer FA Dasanu CA	2014	Corm Med2014，78，4：	1
8	Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke 显示文摘	Montaner J Alvarez - Sabin J Molina CA	2001	Stroke2001，32，12：	1
9	Characterization of the eg95 gene family in the G6 genotype of Echinococcus granulosus显示文摘	Alvarez Rojas CA Gauci CG Nolan MJ	2012	Mol Biochem Parasitol2012，183，2：	1
10	C - reactive pro- tein predicts further ischemic events in first - ever transient ische- mic attack or stroke patients with in tracpranial large - artery oc- clusive disease 显示文摘	Arenillas J F Alvarez - Sabin J Molina CA	2003	Stroke2003，34，：	1
11	Effects of admis- sion hyperglycemia on stroke outcome in reperfused tissue plasmino- gen activator- treated patients显示文摘	Alvarez - Sabin J Molina CA Montaner J	2003	Stroke2003，34，5：	1
12	TCD monitoring of transeervieal carotid stenting with flow reversal protection: a novel carotid revascularization technique 显示文摘	Ribo NI Molina CA Alvarez B el al	2006	Stroke2006，37，：	1
13	C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease 显示文摘	Arenillas JF Alvarez - Sabin J Molina CA	2003	Stroke2003，34，10：	1
14	Effects of admission hyperglycemia on stroke outcome in reperfuse tissue plasminogen activator - treated patients 显示文摘	Alvarez Sabin J Molina CA Moteaner J	2003	Stroke2003，34，5：	1
15	Pulmonary alveolar protei- nosis in association with household exposure to fibrous insulation material显示文摘	McDonald J W Alvarez F Keller CA	2000	Chest2000，117，6：	1
16	Intra-arterial administration of microbubbles and continuous 2-MHz ultrasound insonation to enhance intra-arterial thrombolysis显示文摘	Ribo M Molina CA Alvarez B	2010	J Neuroimaging2010，20，3：	1
17	Copper ions stimulatepolyphosphate degradation and phosphate efflux inAcidithiobacillus ferrooxidans 显示文摘	Alvarez S Jerez CA	2004	Applied andEnvironmental Microbiology2004，70，9：	1
18	Pri- mary diffuse large B - cell lymphoma of the prostate in a young patient 显示文摘	Alvarez CA Rodriguez BI Perez LA	2006	Int Braz J Urol2006，，：	1
19	Matrixmentalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke显示文摘	Montaner J Alvarez Sabin J Mohina CA	2001	Stroke2001，32，：	1
20	C - reactive protein predicts further ischemic events in first - ever transient ischemic attack or stroke patients with intracranial large - artery occlusive disease 显示文摘	Arenillas JF Alvarez - Sabin J Molina CA	2003	Stroke2003，34，：	1

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