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| 1 | Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury显示文摘Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic cavitation.Previously,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue integration.Here,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal cord.Immunohistochemistry demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host interface.Few reactive astroglial or regenerating axonal profiles could be seen traversing this layer.Such encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the implant.Characterization of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine. | Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook | 2019 | Regenerative Biomaterials2019，6，2： | 4 |
| 2 | Relationship between serum osteoprotegerin, glycemic control, renal function and markers of atherosclemsis in type 2 diabetes显示文摘 | Altinova AE Toruner F Akturk M | 2011 | Scand J Clin Lab Invest2011，71，4： | 1 |
| 3 | Adiponeetin levels and car- diovascular risk factors in hypothyroidism and hyperthyroidism 显示文摘 | Altinova AE Toruner FB Akturk M | 2006 | Clinical Endocrinology2006，65，： | 1 |
| 4 | Association of serum levels of IGF-I and IGFBP-1 with renal function in patients with type 2 diabetes mellitus显示文摘 | Akturk M Arslan M Altinova A | | 0，，1： | 1 |
| 5 | Plasma visfatin concentrations in subjects with type 1 diabetes mellitus显示文摘 | Toruner F Altinova AE Bukan N | 2009 | Horm Res2009，72，1： | 1 |
| 6 | Association of serum levels ofIGF-land IGFBP-l with renal function in patients with type 2 diabetes mellitus显示文摘 | Akturk M Arslan M Altinova A Ozdemir A Ersoy R Yetkin I | 2007 | Growth Horm IGF Res2007，17，3： | 1 |
| 7 | Plasma visfatin concentrations in subjects with type 1 diabetes mellitus 显示文摘 | Toruner F Altinova AE Bukan N | 2009 | Horm Res2009，72，1： | 1 |
| 8 | Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester显示文摘 | Akturk M Altinova AE Mert I | | 0，，07： | 1 |
| 9 | Ri6k factors fr cardiovascular disease in patients with subclinical hypothyroidism显示文摘 | Toruner F Altinova AE Karakoc A | 2008 | Adv Ther2008，25，： | 1 |
| 10 | Association of serum levels of IGF-I and IGFBP-I with renal function in patients with type 2 diabe- tes mellitus显示文摘 | Akturk M Arslan M Altinova A | 2007 | Growth Horm IGF Res2007，17，3： | 1 |
| 11 | Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus显示文摘 | Altinova AE Toruner F Bozkurt N | 2007 | Gynecol Endocrinol2007，23，3： | 1 |
| 12 | Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus 显示文摘 | Altinova AE Toruner F Bozkurt N | 2007 | Gynecol Endocfinol2007，23，3： | 1 |
| 13 | The relationship be-tween adipocyte fatty acid binding protein-4, retinol bindingprotein-4 levels and early diabetic nephropathy in patientswith type 2 diabetes 显示文摘 | Toruner F Altinova AE Akturk M | 2011 | Diabetes Res Clin Pract2011，91，2： | 1 |
| 14 | The relationship between adipocyte fatty acid binding protein4, retinol binding protein-4 lev-els and early diabetic nephropathy in patients with type 2 diabetes 显示文摘 | Toruner F Altinova AE Akturk M | 2011 | Diabetes Res Clin Pract2011，91，2： | 1 |
| 15 | Serum IL-18 levels in patients with type 1 diabetes:relations to metaboliccontrol and microvascular complications显示文摘 | Altinova AE Yetkin I Akbay E Bukan N Arslan M | 2008 | Cytokine2008，42，2： | 1 |
| 16 | Reduced serum acylated ghrelin levels in patients with hyperthyroidism显示文摘 | Altinova AE Toruner FB Akturk M | 2006 | Horm Res2006，65，4： | 1 |
| 17 | Factors affecting urethral stricture development after radical retropubie prostatectomy显示文摘 | Altinova S Serefoglu EC Ozdemir AT | 2009 | Int Urol Nephrol2009，41，4： | 1 |
| 18 | Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus 显示文摘 | Altinova AE Tomner F Bozkurt N | 2007 | Gynecol Endocrinol2007，23，3： | 1 |
| 19 | Risk factors for cardio- vascular disease in patients with subclinical hypothyroidism 显示文摘 | Toruner F Altinova AE Karakoe A | 2008 | Adv Ther2008，25，5： | 1 |
| 20 | Robot-as- sisted nerve-sparing radical cystectomy with bilateral extended pelvic lymph node dissection (PLND) and intracorporeal urinary diversion for bladder cancer: initial experience in 27 cases显示文摘 | CANDA AE ATMACA AF ALTINOVA S | 2012 | BJU Int2012，110，： | 1 |
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