|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Presentation of systemic lupus erythematosus in emergency department显示文摘 | Waseem M Alsheikh M Hana A | 2007 | Pediatr Emerg Care2007，23，4： | 1 |
| 3 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，： | 1 |
| 4 | The calcium-binding activity of a vacuole-associated,dehydrin-like protein is regulated by phosphorylation显示文摘 | Heyen B J Alsheikh M K Smith E A Torvik C F Seals D F Randall S K | | 0，，： | 1 |
| 5 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，1： | 1 |
| 6 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，1： | 1 |
| 7 | Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic a- gents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，1： | 1 |
| 8 | Comparison of the WHO/ISUP classification and cytokeratin 20 expression in predicting the behavior of low-Grade papillary urothelial tumors 显示文摘 | Alsheikh A Mohamedali Z Jones E | 2001 | Modern Pathology2001，14，4： | 1 |
| 9 | Effect of aprobiotic infant formula on infections in childcare centers:comparison of two probiotic agents显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，51，： | 1 |
| 10 | Effect of a probiotic infantformula on infections in child care centers: Comparison of twoprobiotic agents显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，： | 1 |
| 11 | Effect of a probiotic infant formula on infections in child care centers:comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，115，1： | 1 |
| 12 | Effect of a probiotic infant formula on infections in child care centers:comparison of two probiotic agents 显示文摘 | Weizman Z Asli G Alsheikh A | 2005 | Pediatrics2005，51，： | 1 |
| 13 | Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation 显示文摘 | Hijawi B Abdallat M Sayaydeh A Alqasrawi S Haddadin A Jaarour N Alsheikh S Alsanouri T | 2013 | East Mediterr Health J2013，19，1： | 1 |
| 14 | Safety and tolerance of a probiotic formu- la in early infancy comparing two probiotic agents: a pilot study 显示文摘 | Weizman Z Alsheikh A | 2006 | J Am Coll Nutr2006，25，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员