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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | Resonance response of scanning force mi- croscopy cantilevers显示文摘 | Chen G Y Warmack R J Thundat T Allison D P Huang A | 1994 | Review of Scientific Instru-ment1994，65，8： | 1 |
| 3 | Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis 显示文摘 | ALLISON M A CHEUNG P CRIQUI M H | 2006 | Circulation2006，113，6： | 1 |
| 4 | Pulsed dye laser treatment of bum scars: alleviation or iiTitation显示文摘 | Allison K P Kiernan M N Waters R A | 2003 | ? Burns2003，29，： | 1 |
| 5 | A CroSS--cultural studyof oral health values 显示文摘 | Allison P Locker D Jokovic A | 1999 | J-Dent Res1999，78，2： | 1 |
| 6 | Cancer immuno- therapy: co - stimulatory agonists and co - inhibitory antagonists 显示文摘 | PEGGES K S QUEZADA S A ALLISON J P | 2009 | Clin Exp Immunol2009，157，1： | 1 |
| 7 | Evaluation of nu- tritional support in acute pancreatitis显示文摘 | LOBO D N MEMON M A ALLISON S P | 2000 | Hr J Surg2000，87，6： | 1 |
| 8 | Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial显示文摘 | Dileep N Lobo Kate A Bostock Keith R Neal Alan C Perkins Brain J Rowlands Simon P Allison | 2002 | The Lancet . 2002 (9320)2002，，9320： | 1 |
| 9 | Hypoth-alamic regulation of cortical bone mass:opposing activity of Y2 re-ceptor and leptin pathway显示文摘 | BALDOCK P A ALLISON S MCDONALD M M | | 0，，10： | 1 |
| 10 | CTLA-4-the costimulatory molecule that doesn't:regulation of T-cell responses by inhibition显示文摘 | CHAMBERS C A ALLISON J P | 1999 | Curr Opin Immunol(Cold Spring Harb Symp Quant Biol)1999，64，1： | 1 |
| 11 | Evaluation of nutritional support in acute panereatitis显示文摘 | Lobo N Memon A Allison P | 2000 | BrJ Surg2000，87，6： | 1 |
| 12 | Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233显示文摘 | GURLEY S N ABIDI A H ALLISON P | 2012 | J Neurooncol2012，110，2： | 1 |
| 13 | Costimulatory regulation of T cell function 显示文摘 | CHAMBERS C A ALLISON J P | 1999 | Curr Opin Cell Biol1999，11，2： | 1 |
| 14 | A RANK / TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function显示文摘 | Allison P A Mark E T Moira G | 2002 | J Biol Chem2002，277，44： | 1 |
| 15 | A RANK/TRAF6- dependent Signal Transduction Pathway Is Essential forOsteoclast Cytoskeletal Organization and Resorp tire Function 显示文摘 | Allison P A Mark E T Moira G et at | 2002 | J BiolChem2002，277，44： | 1 |
| 16 | CTLA-4-the costimulatory molecule that doesn't:regulation of T-cell responses by inhibition显示文摘 | CHAMBERS C A ALLISON J P | 1999 | Curr Opin Immunol(Cold Spring Harb Symp Quant Biol)1999，64，1： | 1 |
| 17 | Evaluation of nutritional support in acute pancreatitis 显示文摘 | Lobo D N Memon M A Allison S P | 2000 | Br J Surg2000，87，6： | 1 |
| 18 | A cross - cultural study of oral health values 显示文摘 | Allison P Locker D Jokovic A | 1999 | J Dent Res1999，78，2： | 1 |
| 19 | Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis显示文摘 | Allison S J Baldock P A Enriquez R F | 2009 | J Bone Miner Res2009，24，2： | 1 |
| 20 | Oxidative stress following traumatic brain injury: enhancement of endogenous antioxidant defense systems and the promise of improved outcome 显示文摘 | Eghwrudjakpor P O Allison A B | 2010 | Niger J Med2010，19，1： | 1 |
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