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| 1 | Macrophage polarization in response to wear particles in vitro显示文摘全部的联合代替是为有停用关节炎和联合机能障碍的病人的治疗的一个高度成功的外科的过程。随着时间的过去,与活动的高水平和关节的用法,然而植入穿粒子从明白表示的表面被产生。这些穿粒子能在 implant (periprosthetic osteolysis ) 附近导致煽动性的反应,和随后的骨头再吞的激活。单核白血球 / 巨噬细胞系的房间安排这长期的煽动性的回答,它被支持 inflammatory (M1 ) 统治巨噬细胞显型而非一反煽动性的支持织物的愈合(M2 ) 巨噬细胞显型。当它被显示出时,那 interleukin-4 (IL-4 ) 有选择地极化向支持骨头愈合的 M2 反煽动性的显型的巨噬细胞,而非发炎,很少对这在通过 IL-4 的极化在哪个是很有效的在发生或调节的时间功课被知道。这个工作的目标是与 polymethyl methacrylate (PMMA ) 的联合响应挑战学习鼠科的巨噬细胞极化和 cytokine 版本的时间功课粒子, lipopolysaccharide (LPS ) 和在 vitro 的 IL-4。有 IL-4 的质问粒子的单核白血球 / 巨噬细胞的处理导致了支持 inflammatory cytokines 和可诱导的氮的氧化物 synthase (iNOS ) 的起始的抑制生产和随后的极化进 M2 反煽动性的显型。当 IL-4 在 PMMA 粒子挑战前被交付时,这结果被优化,到 M1 显型而非到未遂(M0 ) 巨噬细胞。这极化的效果在一堂 5 天的时间功课上被支撑。进 M2 显型的 M1 巨噬细胞的极化可以是策略减轻穿粒子联系 periprosthetic osteolysis。 | Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman | 2013 | Cellular & Molecular Immunology2013，10，6： | 10 |
| 2 | Role of alcohol in pathogenesis of hepatitis B virus infection显示文摘Hepatitis B virus(HBV)and alcohol abuse often contribute to the development of end-stage liver disease.Alcohol abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist chronically.Importantly,the mechanism by which alcohol promotes the progression of HBVassociated liver disease are not completely understood.Potential mechanisms include a suppressed immune response,oxidative stress,endoplasmic reticulum and Golgi apparatus stresses,and increased HBV replication.Certainly,more research is necessary to gain a better understanding of these mechanisms such that treatment(s)to prevent rapid liver disease progression in alcohol-abusing HBV patients could be developed.In this review,we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field. | Murali Ganesan Allison Eikenberry Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2020 | World Journal of Gastroenterology2020，26，9： | 5 |
| 3 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 4 | Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab 显示文摘 | Adams CW Allison DE Flagella K | 2006 | Cancer Immunol Immunother2006，55，6： | 1 |
| 5 | Glycosylation induced increases in blood flow and 125I - albamn permeation : role of nitric oxide and superoxide (abstract) 显示文摘 | Tilton RG Chang K Allison W | 1993 | FASEB1993，7，： | 1 |
| 6 | Robotic-assisted Roux-en-Y gastric bypass:update from 2 high-volume centers显示文摘 | Tieu K Allison N Snyder B | 2013 | Surg Obes Dis2013，9，2： | 1 |
| 7 | Mutational evidence for an internal fusion peptide in flavivirus envelope protein E显示文摘 | Allison SL Schalich J Stiasny K | 2001 | J Virol2001，75，9： | 1 |
| 8 | Progesterone induces calci- tonin expression in the baboon endometriumwithin the windowof- uterine receptivity显示文摘 | Susham K Allison B Yong PC | 2003 | Biol Reprod2003，68，： | 1 |
| 9 | Geant4-a simulation toolkit显示文摘 | Agostinelli S Allison J Amako K | 2003 | Nuclear Instruments and Methods in Physics Research A2003，506，： | 1 |
| 10 | GEANT4:a simulation toolkit显示文摘 | Agosinelli S Allison J Amako K | 2003 | Nuclear Instruments and Methods in Physics Research A2003，506，： | 1 |
| 11 | Microbial activity and soil respiration under nitrogen addition in Alaskan boreal forest显示文摘 | Allison S D Czimczik C I Treseder K K | 2008 | Global Change Biology2008，14，5： | 1 |
| 12 | Geant4 developments and application显示文摘 | Allison J Amako K Apostolakis J | 2006 | IEEE Transactions on Nuclear Science2006，53，1： | 1 |
| 13 | Nitrogen fertilization re- duces diversity and alters community structure of active fungi in boreal ecosystems 显示文摘 | Allison S D Hanson C A Treseder K K | 2007 | Soil Biology and Biochemistry2007，39，8： | 1 |
| 14 | Valuable patents 显示文摘 | Allison J R Lemley M A Moore K A | 2004 | Georgetown Law Journal2004，92，3： | 1 |
| 15 | Functional MRI cerebral activation and deactivation during finger movement显示文摘 | ALLISON J D MEADOR K J LORING D W | 2000 | Neurology2000，54，： | 1 |
| 16 | Annual Deaths Attributable to Obesity in the United States显示文摘 | ALLISON D B FONTAINE K R MANSON J E | 1999 | JAMA1999，282，： | 1 |
| 17 | Valuable patents显示文摘 | Allison J R Lemley M A Moore K A | 2004 | Georgetown Law Journal2004，92，： | 1 |
| 18 | Children's Understanding of E- motional Facial Expressions and Verbal Labels 显示文摘 | Camas LA Allison K | 1985 | Journal of Nonverbal Behavior1985，9，2： | 1 |
| 19 | Co-stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily 显示文摘 | Peggs K Allison J | 2005 | Br J Haematol2005，130，6： | 1 |
| 20 | Micrcstructural stability and creep of rare-earth containing magnesium alloys 显示文摘 | Moreno I P Nany T K Jones J W Allison J E Pollock T M | 2003 | Scripta Materialia2003，48，： | 1 |
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