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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 显示文摘 | Esposito M Grusovin MG Rees J Karasoulos D Felice P Alissa R | 2010 | Cochrane Database Syst Rev2010，，3： | 1 |
| 3 | Basic pathogenetic mechanisms in silicosis : currentunderstanding显示文摘 | Binaya R Alissa K | 2005 | Curr Opinion Pulm onary Med2005，11，： | 1 |
| 4 | Update on progressive familial intrahepatic cholestasis 显示文摘 | Alissa FT Jaffe R Shneider BL | 2008 | J Pediatr Gastroenterol Nutr2008，46，3： | 1 |
| 5 | Schizophrenia and increased risks of cardiovascular disease显示文摘 | Charles H Alissa R Danielle H | 2005 | American Heart Journal2005，150，6： | 1 |
| 6 | Update on progressive familial intrahepatic cholestasis 显示文摘 | Alissa FT Jaffe R Shneider BL | 2008 | J Pediatr Gastroenterol Nutr2008，46，： | 1 |
| 7 | Trophic relations in a streamfood web:importance of fatty acids for macroinvertebrate consum-ers显示文摘 | MONICA T R JOHN D W ALISSA A P | 2007 | Journal of the American Benthological Society2007，26，3： | 1 |
| 8 | Influence of ibuprofen on bone healing around dental implants:a randomised double-blind placebo-controlled clinical study显示文摘 | Alissa R Sakka S Oliver R | | 0，，3： | 1 |
| 9 | Schizophrenia and increased risks of cardiovascular disease显示文摘 | Charles H Alissa R Danielle H | 2005 | American Heart Journal2005，150，6： | 1 |
| 10 | Basic pathogenetic mechanisms in silicosis : current understanding 显示文摘 | Binaya R Alissa K | 2005 | Curr Opinion Pulmonary Med2005，11，2： | 1 |
| 11 | Update on progressive familial intrahepatic cholestasis 显示文摘 | Alissa FT Jaffe R Shneider BL | 2008 | J Pediatr Gastroenterol Nutr2008，46，3： | 1 |
| 12 | Schizophrenia and increased risks of cardiovascular disease显示文摘 | Charles H Alissa R Danielle H | 2005 | American Heart Journal2005，150，6： | 1 |
| 13 | Schizophrenia and increased risks of cardiovascular disease显示文摘 | Charles H Alissa R Danielle H | 2005 | American Heart Journal2005，150，6： | 1 |
| 14 | Update on progressive familial intrahepatic cholestasis 显示文摘 | Alissa FT Jaffe R Shneider BL | 2008 | J Pediatr Gastroenterol Nutr2008，46，3： | 1 |
| 15 | The influence of platelet-rich plasma on the healing of extraction sockets:an explorative random-ised clinical trial显示文摘 | Alissa R Esposito M Horner K | | 0，，02： | 1 |
| 16 | Update on progressive familial intrahepatic cholestasis 显示文摘 | Alissa FT Jaffe R Shneider BL | 2008 | J Pediatr Gastroenterol Nutr2008，46，3： | 1 |
| 17 | The influence of platelet-rich plasma on the healing of extraction sockets:an explorative randomised clinical trial显示文摘 | Alissa R Esposito M Horner K | 2010 | Eur Oal Implantol2010，3，： | 1 |
| 18 | Influence of prognostic risk indicators on osseointegrated dental implant failure:a matched case-control analysis显示文摘 | Alissa R Oliver RJ | 2012 | J Oral Implantol2012，38，1： | 1 |
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