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| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | A sinkhole resilient proto- col for wireless sensor networks: performance and security analysis 显示文摘 | Fabrice L F Antonis P Aline C V | 2012 | Computer Communications2012，35，2： | 1 |
| 3 | Purification of GSK 3 by affinity chromatography on immobilized axin显示文摘 | Aline P Blandine B Marie G | 2000 | Protein Exp and Purifiea2000，20，3： | 1 |
| 4 | Insights into colloid-mediated trace element release at the soil/water interface显示文摘 | Mathieu P Aline D Melanie D | 2008 | Journal of Colloid and Interface Science2008，325，： | 1 |
| 5 | Occupational Exposure of Farm Workers to Pesticides:Biochemical Parameters and Evaluation of Genotoxicity显示文摘 | ALINE P R ALVES M JANE M B | | 0，，： | 1 |
| 6 | The ambivalence of challenge stres- sors :Time pressure associated with both negative and positive well- being 显示文摘 | Widmer P S Semmer N K K'alin W Jacobshagen N Meier L L | 2012 | Journal of Vocational Behav- ior2012，80，2： | 1 |
| 7 | Expression and localization of NK (1) R, substance P and CGRP are altered in dorsal root ganglia neurons of spontaneously hypertensive rats (SHR) 显示文摘 | ALINE BOER P UENO M SANTANA J S | 2005 | Brain Res Mol Brain Res2005，138，： | 1 |
| 8 | Mechanical or bioprosthetic valves in the elderly:a 20-Year comparison显示文摘 | Sidhu P Kane O Alin H | 2001 | Ann J Thorac Surg2001，71，5： | 1 |
| 9 | Climate change decreases aquatic ecosystem productivity of Lake Tanganyika, Africa显示文摘 | O'REILLY C M ALIN S R PLISNIER P D | 2003 | Nature2003，424，6950： | 1 |
| 10 | Climate changedecreases aquatic ecosystem productivity of Lake Tanganyika,Africa显示文摘 | O'Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，6950： | 1 |
| 11 | Climate change decreases aquatic ecosystem productivity of Lake Tanganyi- ka, Africa 显示文摘 | O' Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，： | 1 |
| 12 | The Emergence and Role of Cultural Boundary Spanners in Global Engineering Prcjeet Net- works 显示文摘 | Di Marco M K Taylor J E Alin P | | Journal of Management in Engineering0，，： | 1 |
| 13 | Insights into colloid-mediated trace element release at the soil/water interface显示文摘 | Mathieu P Aline D Melanie D | 2008 | Journal of Colloid and Interface Science2008，325，： | 1 |
| 14 | Purification of GSK-3 by affinity chromatography on immobilized Axin 显示文摘 | Aline P Blandine B Marie G | 2000 | Protein Exp and Purifica2000，20，3： | 1 |
| 15 | Emergence and Role of Cultural Boundary Spanners in Global Engineering Project Networks显示文摘 | DI MARCO M K TAYLOR J E ALIN P | 2010 | Journal of Management in Engineering2010，26，3： | 1 |
| 16 | Identification and validation of reference genes to study the gene expression in Gluconacetobacter diazotrophicus grown in different carbon sources using RT-qPCR显示文摘 | Galisa Pericles S da Silva Helder A P Macedo Aline V M | 2012 | Journal of Microbiological Methods2012，91，1： | 1 |
| 17 | Climate change de- creases aquatic ecosystem productivity of Lake Tanganyika, Afri- ca显示文摘 | O'Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，6950： | 1 |
| 18 | LR1 : a candidate RNA virus of Leishmania 显示文摘 | Tarr P I Aline R F Smiley B L | 1988 | Proc Nat Acad Sci USA1988，85，： | 1 |
| 19 | Occupational exposure of farm workers to pesticides: Biochemical parameters and evaluation of genotoxicity显示文摘 | Aline Pértile Remor Carla Caprini Totti Dariele Alves Moreira Gustavo Pimentel Dutra Vanina Dahlstr?m Heuser Jane Marlei Boeira | 2008 | Environment International2008，，2： | 1 |
| 20 | A multiparameter chaos control method based on OGY approach 显示文摘 | Aline S P Marcelo Amorim S | 2009 | Chaos Solitons Fraetals2009，40，3： | 1 |
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