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36篇 您的检索式：作者名="Ali ME"

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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	A novel concept to preserve the beneficial effects of hormone replacement therapy in bilaterally female ovariectomized rats:role of lovastatin therapy显示文摘	El-Swefy SE Asker ME Ali SI	2002	Pharmacol Res2002，45，3：	1
3	Risk factors and morbidity in patients with placenta previa accreta compared to placenta previa non-accreta显示文摘	Zaki ZM Bahar AM Ali ME	1998	Acta Obstet Gynecol Scand1998，77，5：	1
4	Polyethylene glycol as an alternative poly- mer solvent for nanoparticle preparation 显示文摘	Ali ME Lamprecht A	2013	Int J Pharm2013，456，1：	1
5	Control ed release of high molecular weight hyaluronic Acid from molecularly imprinted hydrogel contact lenses显示文摘	Ali M Byrne ME		0，，03：	1
6	Risk facfors and morhidify in patients with placenta previa accreta compared to placenta previs non-accreta 显示文摘	Zaki ZM Bahar AM Ali ME	1998	Acts Ohster Gynecol Scand1998，77，4：	1
7	Antibody seroprevalences against Peste des Petits Ruminants (PPR) virus in sheep and goats in Sudan显示文摘	Osman NA Ali AS A/Rahman ME	2009	Trop Anim Health Prod2009，41，7：	1
8	Assisted hatching in assisted reproduction: a state of art 显示文摘	Hammadeh ME Fischer-Hammadeh C Ali KR	2011	J Assist Reprod Genet2011，28，2：	1
9	Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4 显示文摘	Mohamed HE Asker ME Ali SI	2004	J Pharm Pharmacol2004，56，6：	1
10	An in vitro ischemic penumbralmimic perfusate increases NADPH oxidase-mediated superoxideproduction in cultured hippocampal neurons 显示文摘	Pamenter ME Ali SS Tang Qt	2012	Brain Res2012，1452，2：	1
11	Five year follow up of biocolonisable microporous fluorocarbon haptic (BIOKOP) keratoprosthesis implantation in patients with high risk of corneal graft failure显示文摘	Alió JL Mulet ME Haroun H	2004	Br J Ophthalmol2004，88，12：	1
12	Lipid peroxidation and human sperm motility: protective role of vitamin E显示文摘	Suleiman SA Ali ME Zaki ZM	1996	J Androl1996，17，5：	1
13	Screening for high risk human papilloma virus(HR-HPV) subtypes,among Sudanese patients with oral lesions显示文摘	Ali YB Faris ME Mohamed SA		0，，04：	1
14	Apoptotic markers in semen of infertile men: Association with cigarette smoking 显示文摘	El-Melegy NT Ali ME	2011	Int Braz J Urol2011，37，4：	1
15	Treatment of childhood nephrotic syndrome with long-term, low-dose tacrolimus 显示文摘	Bock ME Cohn RA Ali FN	2013	Clin Nephrol2013，79，6：	1
16	Molecular mechanisms of anti-hyperglycemic effects of Costus speciosus extract in streptozotocin-induced diabetic rats 显示文摘	ALI HA ALMAGHRABI OA AFIFI ME	2014	Saudi Med J2014，35，12：	1
17	Causes and consequences of hand injury显示文摘	Snith ME Auchincloss 3M Ali MS	1985	J Hand Surg Br1985，10，：	1
18	Risk factors and morbidity in patients with placenta previa accreta compared to placenta previa non-accreta显示文摘	Zaki ZM Bahar AM Ali ME	1998	Acta Obstet Gynecol Scand1998，77，：	1
19	Invasive pulmonary aspergillosis complicating chronic obstructive pulmonary disease in an immunocompe- tent patient显示文摘	Ali ZA Ali AA Tempest ME	2003	J Pnstgrad Med2003，49，1：	1
20	Invasive pulmonary aspergillosis complicating chronic obstructive pulmonary disease in an immunocompe- tent patient显示文摘	Ali ZA Ali AA Tempest ME	2003	J Postgrad Med2003，49，1：	1

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