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| 1 | Acute pancreatitis at the beginning of the 21st century: The state of the art显示文摘Acute pancreatitis is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Gallstones and alcohol consumption are the most frequent causes of pancreatitis in adults. The treatment of mild acute pancreatitis is conservative and supportive; however severe episodes characterized by necrosis of the pancreatic tissue may require surgical intervention. Advanced understanding of the pathology, and increased interest in assessment of disease severity are the cornerstones of future management strategies of this complex and heterogeneous disease in the 21st century. | Alfredo F Tonsi Matilde Bacchion Stefano Crippa Giuseppe Malleo Claudio Bassi | 2009 | World Journal of Gastroenterology2009，15，24： | 54 |
| 2 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis显示文摘AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the'Hospital General de México,Dr.Eduardo Liceaga'.We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+MTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+MTD 500 mg three times daily.The duration of the treatment for all of the groups was 30 d.RESULTS:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(PTX+MTD 59.4%vs PTX 33.3%,P=0.04;PDN+MTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+MTD 50%vs PTX18.2%,P=0.01;PDN+MTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 mo.The patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe AH.Alcohol abstinence is a key factor for survival in these patients.The patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX. | Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan M Abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 3 | Malnutrition negatively impacts the quality of life of patients with cirrhosis: An observational study显示文摘AIM To verify how malnutrition is related to health-related quality of life(HRQL) impairment in patients with cirrhosis.METHODS Data was retrospectively abstracted from medical records and obtained by direct interview. We included patients with cirrhosis from any etiology, evaluated at the Liver Clinic from Gastroenterology Department in a tertiary healthcare center, from June 2014 to June 2016. Child-Pugh score, data about complications, and demographic, clinical and anthropometric characteristics of patients were obtained. Nutritional status was evaluated by the Subjective Global Assessment(SGA). HRQL was evaluated through the Chronic Liver Disease Questionnaire. Patients were requested to assess their global HRQL with the following code: 0 = impairment of HRQL, when it was compared with other healthy subjects; 1 = good HRQL, if it was similar to the quality of life of other healthy subjects. To compare the primary outcome between malnourished and well-nourished groups, the χ~2 test, Fisher's exact test or Student's t-test were used, based on the variable type. Associations between predictor variables and deterioration of HRQL were determined by calculating the hazard ratio and 95% confidence interval using Cox proportional hazards regression. RESULTS A total of 127 patients with cirrhosis were included, and the mean age was 54.1 ± 12.3 years-old. According to Child-Pugh scoring, 25(19.7%) were classified as A(compensated), 76(59.8%) as B, and 26(20.5%) as C(B/C = decompensated). According to SGA, 58(45.7%) patients were classified as well-nourished. Sixty-nine patients identified HRQL as good, and 76 patients(59.8%) perceived impairment of their HRQL. Multivariate analysis to determine associations between predictor variables and self-perception of an impairment of HRQL found strong association with malnutrition(P < 0.0001). The most important impaired characteristics in malnourished patients were: Presence of body pain, dyspnea on exertion with daily activities, decreased appetite, generalized weakness, trouble lifting or carrying heavy objects, and decreased level of energy(P < 0.0001).CONCLUSION Malnutrition is a key factor related to impairment of HRQL in patients with cirrhosis. | Gabriela Rojas-Loureiro Alfredo Servín-Caamano Elizabeth Pérez-Reyes Luis Servín-Abad Fátima Higuerade la Tijera | 2017 | World Journal of Hepatology2017，9，5： | 3 |
| 4 | Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination显示文摘Chronic viral hepatitis is a significant health problem throughout the world,which already represents high annual mortality.By 2040,chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria,vitellogenesis-inhibiting hormone,and tuberculosis altogether.In this review,we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups,the goals set by the World Health Organization for the year 2030,and the key points to achieve them,such as timely access to antiviral treatment of direct-acting antiviral,which represents the key to achieving hepatitis C virus elimination.Likewise,we review the strategies to prevent transmission and achieve control of hepatitis B virus.Finally,we address the impact that the coronavirus disease 2019 pandemic has had on implementing elimination strategies and the advantages of implementing telemedicine programs. | Fátima Higuera-de la Tijera Alfredo Servín-Caamaño Luis Servín-Abad | 2021 | World Journal of Gastroenterology2021，27，26： | 2 |
| 5 | Rapid assessment of the cost-effectiveness of low impact development for CSO control显示文摘 | Montalto F Behr C Alfredo K | 2007 | Landscape amt Urban Planning2007，82，： | 1 |
| 6 | Use of a Dispersed Iron Catalys for Upgrading Extra-Heavy Crude Oil Using Methane as Source of Hydrogen显示文摘 | Cesar O Eduardo F Alfredo M | 2003 | Fuel2003，82，： | 1 |
| 7 | Physical changes during active and passive composting of beef feedlot manure in winter and summer显示文摘 | Francis J Larney Andrew F Olson Alfredo A Carcamo | 2000 | Bioresouce technology2000，75，： | 1 |
| 8 | Chemopreventive property of a soybean peptide (Lunasin) that binds to deacetylated histones and inhibits acetylationl显示文摘 | Alfredo F Galvez Na Chcn Janet Macasieb ct al | 2001 | Cancer Research2001，61，10： | 1 |
| 9 | Respiratory syncytial virus infection : a decade of contributions 显示文摘 | Val Blanco del Alfredo Jos e Mar f a Eiros Bouza Agust f n M? | 2012 | Le Infezioni in Medicina2012，，3： | 1 |
| 10 | Detailed modeling of a flue-gas desulfurisation plant显示文摘 | Antonio G Norberto F Alfredo T | 2007 | Computers and Chemical Engineering2007，31，11： | 1 |
| 11 | Sketch-based retrieval of complex draw- ings using hierarchical topology and geometry显示文摘 | MANUEL F ALFREDO F | 2009 | Computer-Aided Design2009，41，12： | 1 |
| 12 | Effects of conjugated linoleie acid on skeletal muscle triacylglycerol metabolism in hamsters显示文摘 | AMAIA Z ALFREDO F Q MACARUuA M T | 2006 | Nutrition2006，22，5： | 1 |
| 13 | Drug insight : new drugs in development for Parkinson's disease 显示文摘 | CARLO C GIOVANNI F ALFREDO B | 2006 | Nat Clin Pract Neurol2006，2，11： | 1 |
| 14 | Cyclic Elastoplastic Analysis of StructuresConcerning a Fatigue Assessment According to the LocalStrain Approach: An Overview 显示文摘 | Abilio M P De Jesus Helder F S G Pereira* Alfredo SRibeiro | 2008 | Journal of PressureVessel Technology2008，130，8： | 1 |
| 15 | Content- Based retrieval of technical drawings 显示文摘 | MANUEL J FONSECA D ALFREDO F | 2003 | Computers and Graphics2003，27，1： | 1 |
| 16 | Temperature variation on the external root surface during intracanal Er: YAG laser irradiation 显示文摘 | Scaini F Souza - Gabriel AE Alfredo E | 2008 | Photomed Laser Surg2008，26，5： | 1 |
| 17 | Allergy to artichoke: a case report 显示文摘 | Luigi M Simonetta B P Raffaella di G Georgios K Maria F C Alfredo T | 2004 | Revue Francaise d'' Allergologie et d ''Immunologie Clinique2004，44，8： | 1 |
| 18 | Latin American randomized trial of balloon angiop lasty versus coronary stenting in diabetic patients with small vessel reference size ( Latin American Small VesselTrial) :immediate and long - term results显示文摘 | ALFREDO E R MAXIMO R A CARLOS F P | 2005 | Am Heart J2005，150，1： | 1 |
| 19 | Potentiation of the malignant phenotype of the differentiated ARO thyroid cell line by insertion of the bcl - 2 gene 显示文摘 | Fulvio B Lisa F Alfredo F | 1999 | Int J cancer1999，81，： | 1 |
| 20 | In hospital and late results of coronary stents versus conventional balloon angioplasty in acute myocardial infarction (GRAMI trial) 显示文摘 | Alfredo R Victor B Mario F | 1998 | Am J Cardiol1998，81，： | 1 |
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