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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Carlo Pappone Vincenzo Santinelli Francesco Manguso Gabriele Vicedomini Filippo Gugliotta Giuseppe Augello Patrizio Mazzone Valter Tortoriello Giovanni Landoni Alberto Zangrillo Christopher Lang Takeshi Tomita Cézar Mesas Elio Mastella Ottavio Alfieri | 2004 | Circulation: Journal of the American Heart Association2004，，3： | 2 |
| 3 | Recent insights into vitamin D and its receptor 显示文摘 | Messa P Alfieri C Rastaldi MP | 2011 | J Nephrol2011，24，： | 1 |
| 4 | Solitary Necrotic Nodule of the Liver: Diagnosis and Treatment显示文摘 | Alfieri S Carriero C Dogliet to GB | 1997 | Hepatogastroenterology1997，44，16： | 1 |
| 5 | Flt3L therapy following localized tumor irradiation generates long-term protective immune response in metastatic lung cancer:its implication in designing a vaccination strategy显示文摘 | Chakravarty PK Guha C Alfieri A | | 0，，： | 1 |
| 6 | Flt3L therapy following localized tumor irradiation generates long-term protective immune response in metastatic lung cancer: its implication in designing a vaccination strategy 显示文摘 | Chakravarty PK Guha C Alfieri A | 2006 | Ontology2006，70，4： | 1 |
| 7 | Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by H-l-decoupled-P-31 magnetic resonance spectroscopy 显示文摘 | MURUGANANDHAM M ALFIERI A MATEI C | 2005 | Clin Cancer Res2005，11，9： | 1 |
| 8 | Solitary necrotic nodule of the liver:diagnosis and treatment显示文摘 | Alfieri S Carriero C Doglietto G B | 1997 | Hepatogastroenterology1997，44，16： | 1 |
| 9 | Tumor biology-guided radio- therapy treatment planning: gross tumor volume versus functional tu- mor volume 显示文摘 | Guha C Alfieri J Blaufox MD | 2008 | Semin Nuel Med2008，2，： | 1 |
| 10 | Bovine herpesvirus type 1 abortions detected by a semi-nested PCR in Brazilian cat- tle herds显示文摘 | Takiuchi E Medici K C Alfieri A F | 2005 | Res Vet Sci2005，79，： | 1 |
| 11 | Metabolic signa-tures associated with a NAD synthesis inhibitor-induced tumor ap-optosis identified by 1Hdecoupled-31P magnetic resonance spec-troscopy显示文摘 | Muruganandham M Alfieri AA Matei C | 2005 | Clin Cancer Res2005，11，9： | 1 |
| 12 | Synthesis,and X-ray Crystal and Molecular Structure of Novel Macrobicyclic Ligand: Crown p-tert-butyl-calixarene显示文摘 | Alfieri C Dradi E Pochini A | 1983 | J Chem Soc Chem Commun1983，19，： | 1 |
| 13 | Laparoscopic treatment of ectopic pregnancy resulting from intrauterine transmigrafion显示文摘 | Pasini A Alfieri L Belloni C | 2001 | BrJObstet Gynecol2001，108，5： | 1 |
| 14 | Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat ceils fromapoptosis 显示文摘 | Fumarola C La Monica S Alfieri RR | 2005 | Cell Death Differ2005，12，10： | 1 |
| 15 | Eight-and-a-halfsyndrome combined with an ipsilateral vertical gaze palsy:a pathophysiological explanation显示文摘 | Marquart C Strauss C Alfieri A | 2013 | Clin Neurol Neurosurg2013，115，： | 1 |
| 16 | Cell size reduction in- duced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat ceils from apoptosis显示文摘 | Fumarola C La Monica S Alfieri RR | 2005 | Cell Death Differ2005，12，10： | 1 |
| 17 | Calcium and osteoprotegerin levels predict the progression of the abdominal aortic calcifications after kidney transplantation 显示文摘 | Meneguini M Regalia A Alfieri C | 2013 | Transplantation2013，96，1： | 1 |
| 18 | Solitary necrotic nodule of the liver: diagnosis and treatment 显示文摘 | Alfieri S Carriero C Doglietto GB | 1997 | Hepatogastroenterology1997，44，16： | 1 |
| 19 | A novel anti-apoptosis gene survivin,expressed in cancer and lymphoma 显示文摘 | AMBROSINI G ADIDA C ALFIERI DC | 1997 | Nature Med1997，3，8： | 1 |
| 20 | Synthesis, and X - ray crystal and molecular structure of a novel macro - bicyclic ligand : Crowned p - t - butyl - calix arene 显示文摘 | ALFIERI C DRADI E POCHINI A | 1983 | J Chem Soc - Chem Com1983，，19： | 1 |
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