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| 1 | Hepatitis B vaccine by intradermal route in non responder patients:An update显示文摘Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus(HBV)infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90%of general population.Individuals who develop an antiHBs titer less than 10 mIU/mL after primary vaccination cycle are defined'no responders'.Many factors could cause a non response to the HBV vaccination,such as administration of the vaccine in buttocks,impaired vaccine storage conditions,drug abuse,smoking,infections and obesity.Moreover there are some diseases,like chronic kidney disease,human immunodeficiency virus infection,chronic liver disease,celiac disease,thalassaemia,typeⅠdiabetes mellitus,down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects.To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection.Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route.This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients.A comprehensive review of the literature using PubMed database,with appropriate terms,was undertaken for articles in English published since 1983.The literature search was undertaken in September 2013. | Martina Filippelli Elena Lionetti Alessia Gennaro Angela Lanzafame Teresa Arrigo Carmelo Salpietro Mario La Rosa Salvatore Leonardi | 2014 | World Journal of Gastroenterology2014，20，30： | 12 |
| 2 | The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage显示文摘 | Sabrina Strano Olimpia Monti Natalia Pediconi Alessia Baccarini Giulia Fontemaggi Eleonora Lapi Fiamma Mantovani Alexander Damalas Gennaro Citro Ada Sacchi Giannino Del Sal Massimo Levrero Giovanni Blandino | 2005 | Molecular Cell2005，，4： | 1 |
| 3 | New approaches in hepatitis B vaccination for celiac disease显示文摘 | Martina Filippelli Elena Lionetti Alfredo Pulvirenti Alessia Gennaro Angela Lanzafame Gianluigi L Marseglia Carmelo Salpietro Mario La Rosa Salvatore Leonardi | 2014 | Immunotherapy2014，，8： | 1 |
| 4 | The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage显示文摘 | Sabrina Strano Olimpia Monti Natalia Pediconi Alessia Baccarini Giulia Fontemaggi Eleonora Lapi Fiamma Mantovani Alexander Damalas Gennaro Citro Ada Sacchi Giannino Del Sal Massimo Levrero Giovanni Blandino | 2005 | Molecular Cell2005，，4： | 1 |
| 5 | Two rare cases of benign hyperlipasemia in children显示文摘Gullo's syndrome is a newly identified condition characterized by a chronic elevation of pancreatic amylase and/or lipase in the absence of pancreatic disease. Until now, only one case of benign isolated hyperlipasemia in children has been recorded. We describe two children with benign and not familial increase of serum lipase. Case 1: a six year old girl presented with occasional discovery of serum lipase elevation. Medical history was silent for pancreatic hyperenzymemia. The screening for possible causes for elevated lipase(genetic, autoimmune and infectious diseases) was normal. The serum lipase increased three fold over the upper limit(193 U/L; reference range 0-60 U/L), with daily fluctuation of values. Both ultrasound scan and magnetic resonance imaging were normal. The genetic mutation associated with chronic pancreatitis was negative. We followed up this patient for two years with blood tests every six months and she did not show any signs or symptoms of pancreatic disease, except for the high level of lipase serum. Case 2: an eight year old girl complained of nausea, vomiting and severe abdominal pain in theepigastric region after eating for the last two weeks. Full blood count, electrolytes, C-reactive protein, liver and renal function were normal. Serum lipase was 96 U/L(reference range 0-60 U/L). The screening for the possible causes of pancreatic disease was negative. Endoscopy of the upper gastrointestinal tract, ultrasound, computed tomography scan and magnetic resonance imaging were normal. One year after the presentation of the symptoms, the patient became asymptomatic although the level of serum lipase continued to be high. | Elena Lionetti Ruggiero Francavilla Salvatore Leonardi Stefania Tomarchio Alessia Gennaro Chiara Franzonello Mario La Rosa | 2014 | World Journal of Clinical Cases2014，2，1： | 0 |
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