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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Genetic influ- ences of adiponectin on insulin resistance, type 2 dia- betes, and cardiovascular disease显示文摘 | Claudia M Vincenzo T Alessandro D | 2007 | Diabetes2007，56，： | 1 |
| 3 | Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences 显示文摘 | Dzieciatkowska M D' Alessandro A Burke TA | 2014 | J Proteomics2014，112，： | 1 |
| 4 | Low-grade myofibroblastic sarcoma of the oral cavity 显示文摘 | Frederica D Alessandro B Laura M | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，108，2： | 1 |
| 5 | Continuous electrospinning of aligned polymer nanofibers onto a wire drum collector显示文摘 | KATTA P ALESSANDRO M RAMSIER R D | 2004 | Nano Letters2004，4，11： | 1 |
| 6 | Self-organized porphyrinic materials显示文摘 | CHARLES M D ALESSANDRO V IVANA R | 2009 | Chem Rev2009，109，5： | 1 |
| 7 | Renal transplantation in adults with Henoch-Schonlein purpura:long-term outcome显示文摘 | Gabriella M Beniamina G Alessandro D | | 0，，09： | 1 |
| 8 | Advances and challenges in the identification of volatiles that mediate interactions among plants and arthropods 显示文摘 | D'Alessandro M Turlings TCJ | 2006 | The Analyst2006，131，1： | 1 |
| 9 | Continuous energy var- iation during the seizure cycle:towards an on-line accumulated energy显示文摘 | Esteller R Echauz J D'alessandro M | 2005 | Clin Neurophysiol2005，116，3： | 1 |
| 10 | Genetic influences of adiponectin on insulin resistance,type2diabetes,and cardiovascular disease显示文摘 | Claudia M Vincenzo T Alessandro D | 2007 | Diabetes2007，56，5： | 1 |
| 11 | Effector Th-1 cells with cytotoxic function in the intestinal lamina propfia of patients with Crohn' s disease 显示文摘 | Mariani P Bachetoni A Alessandro M D | 2000 | Digestive Diseases and Sciences2000，45，10： | 1 |
| 12 | Continuous electrospinning of aligned polymer nanofibers onto a wire drum collector 显示文摘 | KATTA P ALESSANDRO M RAMSIER R D | 2004 | Nano Letters2004，4，11： | 1 |
| 13 | Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro显示文摘 | Tassone P Tagliaferri P Viscomi C Palmieri C Caraglia M D' Alessandro A | 2003 | Br J Cancer2003，88，： | 1 |
| 14 | Renal transplantation in adults with Henoch-Schonlein purpura: long-term outcome 显示文摘 | Gabriella M Beniamina G Alessandro D | 2008 | Neph Dia Trans2008，23，9： | 1 |
| 15 | Early elevation of interleukin-1 beta and interleukin-6 levels after bare or drug-eluting stent implantation in patients with stable angina显示文摘 | Sardella G Mariani P D'Alessandro M | 2006 | Throb Res2006，117，6： | 1 |
| 16 | Serum tissue polypeptide specific antigen (TPS):a complementary tumor marker to CA15-3 in the managementof breast cancer显示文摘 | D'Alessandro R Roselli M Ferroni P | | 0，，： | 1 |
| 17 | A Randomized double- bllnd,placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 mi nutes显示文摘 | Bar-Or D Salottolo M Alessandro O | 2012 | European Urology2012，61，7： | 1 |
| 18 | Continuous electrospinning of aligned polymer nanofibers onto a wire drum collector显示文摘 | Katta P Alessandro M Ramsier R D | 2004 | Nano letters2004，4，11： | 1 |
| 19 | Continuous electrospinning of aligned polymer nanofibers onto a wire drum collector显示文摘 | P Katta M Alessandro R D Ramsier G G Chase | 2004 | Nano Letters2004，4，： | 1 |
| 20 | Early elevation of interleukin-1 beta and interleukin-6 levels after bare or drug-eluting stent implantation in patients with stable angina显示文摘 | Sardella G Mariani P D'Alessandro M | 2006 | Throb Res2006，117，6： | 1 |
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