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1篇 您的检索式：作者名="Alessandro Fatatis"

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		题名	作者	年代	出处	被引量
	1	Implication of platelet-derived growth factor receptor alpha in prostate cancer skeletal metastasis显示文摘Metastasis represents by far the most feared complication of prostate carcinoma and is the main cause of death for patients.The skeleton is frequently targeted by disseminated cancer cells and represents the sole site of spread in more than 80% of prostate cancer cases.Compatibility between select malignant phenotypes and the microenvironment of colonized tissues is broadly recognized as the culprit for the organ-tropism of cancer cells.Here,we review our recent studies showing that the expression of platelet-derived growth factor receptor alpha(PDGFR a) supports the survival and growth of prostate cancer cells in the skeleton and that the soluble fraction of bone marrow activates PDGFR a in a ligand-independent fashion.Finally,we offer pre-clinical evidence that this receptor is a viable target for therapy.	Qingxin Liu Danielle Jernigan Yun Zhang Alessandro Fatatis	2011	Chinese Journal of Cancer2011，30，9：	3

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