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| 1 | Radioembolisation and portal vein embolization before resection of large hepatocellular carcinoma显示文摘Resectability of hepatocellular carcinoma in patients with chronic liver disease is dramatically limited by the need to preserve sufficient remnant liver in order to avoid postoperative liver insufficiency. Preoperative treatments aimed at downsizing the tumor and promoting hypertrophy of the future remnant liver may improve resectability and reduce operative morbidity. Here we report the case of a patient with a large hepatocellular carcinoma arising from chronic liver disease. Preoperative treatment, including tumor downsizing with transarterial radioembolization and induction of future remnant liver hypertrophy with right portal vein embolization, resulted in a 53% reduction in tumor volume and compensatory hypertrophy in the contralateral liver. The patient subsequently underwent extended right hepatectomy with no postoperativesigns of liver decompensation. Pathological examination demonstrated a margin-free resection and major tumor response. This new therapeutic sequence, combining efficient tumor targeting and subsequent portal vein embolization, could improve the feasibility and safety of major liver resection for hepatocellular carcinoma in patients with liver injury. | Fikri Bouazza Arthur Poncelet Camilo Alejandro Garcia Philippe Delatte Jean Luc Engelhom Maria Gomez Galdon Amélie Deleporte Alain Hendlisz Bruno Vanderlinden Patrick Flamen Vincent Donckier | 2015 | World Journal of Gastroenterology2015，21，32： | 2 |
| 2 | A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas显示文摘Background:Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban settings.There is a need to know what rapid diagnostic technologies are available,have been properly assessed,and are being implemented to improve control of these diseases in the urban context.This paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty.Main body:A scoping review was conducted.Peer-reviewed and grey literature were searched using terms describing the targeted infectious diseases,diagnostics evaluations,rapid tests,and urban setting.The review was limited to studies published between 2000 and 2016 in English,Spanish,French,and Portuguese.Inclusion and exclusion criteria were refined post hoc to identify relevant literature regardless of study design and geography.A total of 179 documents of the 7806 initially screened were included in the analysis.Malaria(n=100)and tuberculosis(n=47)accounted for the majority of studies that reported diagnostics performance,impact,and implementation outcomes.Fewer studies,assessing mainly performance,were identified for visceral leishmaniasis(n=9),filariasis and leptospirosis(each n=5),enteric fever and schistosomiasis(each n=3),dengue and leprosy(each n=2),and Chagas disease,human African trypanosomiasis,and cholera(each n=1).Reported sensitivity of rapid tests was variable depending on several factors.Overall,specificities were high(>80%),except for schistosomiasis and cholera.Impact and implementation outcomes,mainly acceptability and cost,followed by adoption,feasibility,and sustainability of rapid tests are being evaluated in the field.Challenges to implementing rapid tests range from cultural to technical and administrative issues.Conclusions:Rapid diagnostic tests for vector-borne and other diseases of poverty are being used in the urban context with demonstrated impact on case detection.However,most evidence comes from malaria rapid diagnostics,with variable results.While rapid tests for tuberculosis and visceral leishmaniasis require further implementation studies,more evidence on performance of current tests or development of new alternatives is needed for dengue,Chagas disease,filariasis,leptospirosis,enteric fever,human African trypanosomiasis,schistosomiasis and cholera. | Lyda Osorio Jonny Alejandro Garcia Luis Gabriel Parra Victor Garcia Laura Torres Stephanie Degroote Valery Ridde | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 3 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 4 | Natural killer cell receptors: functional roles显示文摘 | Garcia CA RobinsonJ Alejandro MadrigalJ | 2003 | Immunol2003，2，22： | 1 |
| 5 | Molecular evolution of hepatitis A virus:a New classification based on the complete VP1protein显示文摘 | Mauro C M Juan Cristina Hector Romero Raoul Perez-Bercof Didier Casane Rodney Colina Laura Garcia Ines Vega Graciela Glikman Victor Romanowsky Alejandro Castello Elisabeth Nicand | 2002 | J Virol2002，76，18： | 1 |
| 6 | Statistical error in particle simulations of hydrodynamic phenomena显示文摘 | NICOLAS G HADJICONSTANTINOU ALEJANDRO L GARCIA MARTIN Z BAZANT GANG HE | | 0，，01： | 1 |
| 7 | A particle method with adjustable transport properties—the generalized consistent Boltzmann algorithm显示文摘 | Alejandro L. Garcia Francis J. Alexander Berni J. Alder | 1997 | Journal of Statistical Physics (-)1997，，1： | 1 |
| 8 | Litter dynamics in riverine mangrove forests in the Guayas River estuary, Ecuador显示文摘 | Robert R. Twilley Mireya Pozo Victor H. Garcia Victor H. Rivera-Monroy Ramon Zambrano Alejandro Bodero | 1997 | Oecologia1997，，1： | 1 |
| 9 | Comparison of Kinetic Theory and Hydrodynamics for Poiseuille Flow显示文摘 | Yihao Zheng Alejandro L. Garcia Berni J. Alder | 2002 | Journal of Statistical Physics (-)2002，，3： | 1 |
| 10 | Laparoscopic total colectomy for colonic inertia: surgical and functional results显示文摘 | George Pinedo Alejandro Jose Zarate Eduardo Garcia Maria Elena Molina Francisco Lopez álvaro Zú?iga | 2009 | Surgical Endoscopy2009，，1： | 1 |
| 11 | Adaptive Mesh and Algorithm Refinement Using Direct Simulation Monte Carlo显示文摘 | Alejandro L Garcia John B Bell William Y Crutchfield Berni J Alder | 1999 | Journal of Computational Physics1999，，1： | 1 |
| 12 | Comparison of Kinetic Theory and Hydrodynamics for Poiseuille Flow显示文摘 | Yihao Zheng Alejandro L. Garcia Berni J. Alder | 2002 | Journal of Statistical Physics (-)2002，，3： | 1 |
| 13 | Defeasible logic programming: an argumentative approach显示文摘 | ALEJANDRO J GARCIA GUILLERMO R | 2004 | Theory and practice of logic programming2004，4，2： | 1 |
| 14 | Liver Transplantation in Latin America: The State-of-the-Art and Future Trends显示文摘 | Paolo R. Salvalaggio Juan C. Caicedo Luiz Carneiro de Albuquerque Alan Contreras Valter D. Garcia Guilherme E. Felga Rafael J. Maurette José O. Medina-Pestana Alejandro Ni?o-Murcia Lucio F. Pacheco-Moreira Juan Rocca Manuel Rodriguez-Davalos Andres Ruf Lu | 2014 | Transplantation2014，，3： | 1 |
| 15 | The Impulsivity and Drinking Motives as Predictor of the Alcohol Consumption in College Students显示文摘 | Diana Betancourt Ocampo Sahid Rafael Garcia Campos Jazmin Garcia Zarate Laura Alejandra Corona Guevara Alejandro Gonzalez-Gonzfilez | 2014 | Psychology Research2014，4，1： | 1 |
| 16 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | 2013 (defa)2013，，： | 1 |
| 17 | Stabilization of thermal lattice Boltzmann models显示文摘 | Guy R. McNamara Alejandro L. Garcia Berni J. Alder | 1995 | Journal of Statistical Physics (-)1995，，1： | 1 |
| 18 | Mutations in foregut SOX2^+ cells induce efficient proliferation via CXCR2 pathway显示文摘Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2^+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KRAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the CXCR2 pathway in driving hyperplasia. Collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics. | Tomoaki Hishida Eric Vazquez-Ferrer Yuriko Hishida-Nozaki Ignacio Sancho-Martinez Yuta Takahashi Fumiyuki Hatanaka Jun Wu Alejandro Ocampo Pradeep Reddy Min-Zu Wu Laurie Gerken Reuben J. Shaw Concepcion Rodriguez Esteban Christopher Benner Hiroshi Nakagawa Pedro Guillen Garcia Estrella Nunez Delicado Antoni Castells Josep M. Campistol Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2019 | Protein & Cell2019，10，7： | 1 |
| 19 | The previous use of digoxin does not worsen early outcome of acute coronary syndromes: an analysis of the ARIAM Registry显示文摘 | Juan Carlos Garcia-Rubira Manuel Calvo-Taracido Francisca Francisco-Aparicio Manuel Almendro-Delia Alejandro Recio-Mayoral Antonio Reina Toral Oscar Aramburu-Bodas Pastora Gallego García de Vinuesa José Maria Cruz Fernández Angel Garcia Alcántara Rafael H | 2014 | Internal and Emergency Medicine2014，，7： | 1 |
| 20 | How GLOBALIZATION INFLUENCES CORPORATE GOVERNANCE AND CORPORATE SOCIAL RESPONSIBILITY IN THE WORLD -- THE SECOND GENEVA-HARVARD-RENMIN-SYDNEY CONFERENCE ON CORPORATE GOVERNANCE AND CORPORATE SOCIAL RESPONSIBILITY (JULY 11--12, 2014)显示文摘 | GUO Rui Alejandro GARCIA JIMENEZ ZUO Zhenbin | 2015 | Frontiers of Law in China-Selected Publications from Chinese Universities2015，10，1： | 1 |
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