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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Social Functioning,Psychological Functioning, and Quality of Life in Epilepsy显示文摘 | Suurmeijer TP Reuvekamp MF Aldenkamp BP | 2001 | Epilepsia2001，42，9： | 1 |
| 3 | Newer antiepileptic drugs andcognitive issues显示文摘 | Aldenkamp AP De Krom M Reijs R | 2003 | Epilepsia2003，44，6： | 1 |
| 4 | The ketogenic diet as a treatment option in adults with chronic refractory epilepsy: effica?cy and tolerability in clinical practice显示文摘 | Lmbrechts OA Wielders LH Aldenkamp AP | 2012 | Epilepsy Behav2012，23，3： | 1 |
| 5 | Cognitive effects of a new pyrrolidine derivative(levetiracetam)in patients w ith epilepsy显示文摘 | Neyens LG Alpherts WC Aldenkamp AP | 1995 | Prog Neuropsychopharmacol Biol Psychiatry1995，19，3： | 1 |
| 6 | Effects of epileptiform EEG discharges on cognitive function: is the concept of 'transient cognitive impairment' still valid ? 显示文摘 | Aldenkamp AP Arends J | 2004 | Epilepsy Behav2004，5，1： | 1 |
| 7 | Behaviour, cognition and epilepsy 显示文摘 | Aldenkamp AP Bodde N | 2005 | Acta Neurol Scand Suppl2005，182，： | 1 |
| 8 | Randomized, double blind parallel group study comparing cognitive effect s of a low dose lamotrigine with valproate and placebo in heathy volunteers 显示文摘 | Aldenkamp A P Arends J Bootsma H P | 2002 | Epilepsia2002，43，1： | 1 |
| 9 | Acute effects of subclinical epileptiform EEG discharges on cognitive activation 显示文摘 | Aldenkamp AP Beitler J Arends J | 2005 | Funct Neurol2005，20，1： | 1 |
| 10 | Cognitive and behavioral effects of nocturnal epileptiform discharges in children with benign cbildhood epilepsy with centrotemporal spikes显示文摘 | Nicolai J Aldenkamp AP Arends J | 2006 | Epilepsy & Behav- ior2006，8，1： | 1 |
| 11 | Effects of epileptiform EEG discharges on cognitive function:is the concept of ' transient cognitive impairment'still valid显示文摘 | Aldenkamp AP Arends J | | 0，，1： | 1 |
| 12 | Topiramate in clinical practice : long-term experience in patients with refractory epilepsy referred to a tertiary epilepsy center 显示文摘 | Bootsma HPR Coolen F Aldenkamp AP | 2004 | Epilepsy and Behavior2004，5，： | 1 |
| 13 | Cognitive and behavioral effects of nocturnal epileptiform discharges in children with benign childhood epilepsy with centrotempo- ral spikes 显示文摘 | Nicolai J Aldenkamp AP Arends J | 2006 | Epilepsy Behav2006，8，1： | 1 |
| 14 | Newer antiepileptic drugs and cognitive issues显示文摘 | Aldenkamp AP De krom M Reijs R | | 0，，06： | 1 |
| 15 | Newer antiepileptie drugs and cognitive issues显示文摘 | Aldenkamp AP de Krom M Reijs R | 2003 | Epilepsia2003，44，4： | 1 |
| 16 | A multicenter,randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures显示文摘 | Baker G | 2000 | Epilepsia2000，41，： | 1 |
| 17 | Usefulness of language and memory testing during intracarotid amobarbital testing:observations from an fMRI study显示文摘 | Aldenkamp AP Boon PA Dellaere K | 2003 | Acta Neuro Scand2003，108，3： | 1 |
| 18 | Newer antiepileptic drugs andcognitive issues显示文摘 | Aldenkamp AP De Krom M Reijs R | 2003 | Epilepsia2003，44，4： | 1 |
| 19 | Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrlgine with valproate and placebo in healthy volunteers显示文摘 | ALDENKAMP AP ARENDS J BOOTMSA HP | 2002 | Epilepsia2002，43，1： | 1 |
| 20 | Cognitive and behavioral effects of nocturnal epileptiform discharges in children with be- nign childhood epilepsy with centrotemporal spikes显示文摘 | Nicolai J Aldenkamp AP Arends J | 2006 | Epilepsy Behav : E&B2006，8，1： | 1 |
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