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| 1 | Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders显示文摘Herbal traditional Chinese medicine(TCM) is used to treat several ailments, but its efficiency is poorly documented and hence debated, as opposed to modern medicine commonly providinge ffective therapies. The aim of this review article is to present a practical reference guide on the role of herbal TCM in managing gastrointestinal disorders, supported by systematic reviews and evidence based trials. A literature search using herbal TCM combined with terms for gastrointestinal disorders in Pub Med and the Cochrane database identified publications of herbal TCM trials. Results were analyzed for study type, inclusion criteria, and outcome parameters. Quality of placebo controlled, randomized, double-blind clinical trials was poor, mostly neglecting stringent evidence based diagnostic and therapeutic criteria. Accordingly, appropriate Cochrane reviews and meta-analyses were limited and failed to support valid, clinically relevant evidence based efficiency of herbal TCM in gastrointestinal diseases, including gastroesophageal reflux disease, gastric or duodenal ulcer, dyspepsia, irritable bowel syndrome, ulcerative colitis, and Crohn's disease. In conclusion, the use of herbal TCM to treat various diseases has an interesting philosophical background with a long history, but it received increasing skepticism due to the lack of evidence based efficiency as shown by high quality trials; this has now been summarized for gastrointestinal disorders, with TCM not recommended for most gastrointestinal diseases. Future studies should focus on placebo controlled, randomized, double-blind clinical trials, herbal product quality and standard criteria for diagnosis, treatment, outcome, and assessment of adverse herb reactions. This approach will provide figures of risk/benefit profiles that hopefully are positive for at least some treatment modalities of herbal TCM. Proponents of modern herbal TCM best face these promising challenges of pragmaticmodern medicine by bridging the gap between the two medicinal cultures. | Rolf Teschke Albrecht Wolff Christian Frenzel Axel Eickhoff Johannes Schulze | 2015 | World Journal of Gastroenterology2015，21，15： | 19 |
| 2 | Drug and herb induced liver injury: Council for International Organizations of Medical Sciences scale for causality assessment显示文摘Causality assessment of suspected drug induced liver injury(DILI) and herb induced liver injury(HILI) is hampered by the lack of a standardized approach to be used by attending physicians and at various subsequent evaluating levels. The aim of this review was to analyze the suitability of the liver specific Council for International Organizations of Medical Sciences(CIOMS) scale as a standard tool for causality assessment in DILI and HILI cases. PubMed database was searched for the following terms: drug induced liver injury; herb induced liver injury; DILI causality assessment; and HILI causality assessment. The strength of the CIOMS lies in its potential as a standardized scale for DILI and HILI causality assessment. Other advantages include its liver specificity and its validation for hepatotoxicity with excellent sensitivity, specificity and predictive validity, based on cases with a positive reexposure test. This scale allows prospective collection of all relevant data required for a valid causality assessment. It does not require expert knowledge in hepatotoxicity and its results may subsequently be refined. Weaknesses of the CIOMS scale include the limited exclusion of alternative causes and qualitatively graded risk factors. In conclusion, CIOMS appears to be suitable as a standard scale for attending physicians, regulatory agencies, expert panels and other scientists to provide a standardized, reproducible causality assessment in suspected DILI and HILI cases, applicable primarily at all assessing levels involved. 2014 Baishideng Publishing Group Co., Limited. All | Rolf Teschke Albrecht Wolff Christian Frenzel Alexander Schwarzenboeck Johannes Schulze Axel Eickhoff | 2014 | World Journal of Hepatology2014，6，1： | 11 |
| 3 | Regulatory causality evaluation methods applied in kava hepatotoxicity: Are they appropriate?显示文摘 | Rolf Teschke Albrecht Wolff | 2010 | Regulatory Toxicology and Pharmacology2010，，1： | 2 |
| 4 | Kava hepatotoxicity: Comparison of aqueous, ethanolic, acetonic kava extracts and kava–herbs mixtures显示文摘 | Rolf Teschke Alexander Genthner Albrecht Wolff | 2009 | Journal of Ethnopharmacology2009，，3： | 2 |
| 5 | Clinical and causality assessment in herbal hepatotoxicity显示文摘 | Rolf Teschke Alexander Schwarzenboeck Axel Eickhoff Christian Frenzel Albrecht Wolff Johannes Schulze | 2013 | Expert Opinion on Drug Safety2013，，3： | 1 |
| 6 | Herbal hepatotoxicity: a tabular compilation of reported cases显示文摘 | Rolf Teschke Albrecht Wolff Christian Frenzel Johannes Schulze Axel Eickhoff | 2012 | Liver Int2012，，10： | 1 |
| 7 | Black cohosh hepatotoxicity: quantitative causality evaluation in nine suspected cases显示文摘 | Rolf Teschke Ruediger Bahre Johannes Fuchs Albrecht Wolff | 2009 | Menopause2009，，5： | 1 |
| 8 | Towards the entire proteome of the model bacterium Bacillus subtilis by gel-based and gel-free approaches 显示文摘 | Wolff S Antelmann H Albrecht D | 2007 | Journal of Chromatography B2007，849，： | 1 |
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