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| 1 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 2 | Utility of vol- ume adjusted prostate specific antigendensity in the diagnosis of prostate cancer in Arab men显示文摘 | SHEIKH M AL SAEED O KEHINDE E O | 2005 | Int Urol Nephrol2005，37，4： | 1 |
| 3 | Effica- cy of dexmedetomidine in suppressing cardiovascular and hormonal responses to general anaesthesia for caesarean delivery: a dose -re- sponse study显示文摘 | EL TAHAN M R MOWAFI H A AL SHEIKH L H | 2012 | Int J Obstet Anesth2012，21，3： | 1 |
| 4 | Laparoscopic versus open partial nephrectomy显示文摘 | Beasley KA AL Omar M Sheikh A | 2004 | Urology2004，64，3： | 1 |
| 5 | Comparison of visual recovery and refractive stability between femtosecond laser-assisted cataract surgery and standard phacoemulsification:six-month follow-up显示文摘 | Conrad-Hengerer I Al Sheikh M Hengerer F H | 2015 | Journal of Cataract&Refractive Surgery2015，41，7： | 1 |
| 6 | Comparison of visual recovery and refractive stability between femtosecond laser-assisted cataract surgery and standard phacoemulsification : six-month follow-up 显示文摘 | Conrad-Hengerer I Al Sheikh M Hengerer FH | 2015 | J Cataract Refract Surg2015，41，： | 1 |
| 7 | Delivery systems for molecular vaccination 显示文摘 | al Shamisi M Morrow WJ | 2000 | Curr Opin Mol Ther2000，2，1： | 1 |
| 8 | Effect of solution pH, ionic strength, and temperature on adsorption behavior of reactive dyes on activated carbon 显示文摘 | Al - Degs Y S El - Barghouthi M I El - Sheikh A H | 2008 | Dyes and Pigmems2008，77，： | 1 |
| 9 | Efficacy of Dexmedetomidine in suppressing cardiovascular and hormonal re- sponses to general anaesthesia for caesarean delivery : a dose - re- sponse study显示文摘 | EL TAHAN M R MOWAFI H A AL SHEIKH I H | 2012 | Int J Obstet Anesth2012，21，3： | 1 |
| 10 | Utility of volume adjusted prostate specific antigen density in the diagnosis of prostate cancer in Arab men显示文摘 | Sheikh M Al Saeed O Kehinde EO | 2005 | Intern Urol Nephrol2005，37，4： | 1 |
| 11 | Efficacy of dexmedetomidine in suppressing cardiovascular and hormonal responses to general anaesthesia for caesarean delivery: a dose-response study显示文摘 | EL-TAHAN M R MOWAFI H A AL SHEIKH I H | 2012 | International Journal of Ob- stetric Anesthesia2012，21，3： | 1 |
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