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| 1 | Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome显示文摘AIM:To compare the utility of the Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA)and Asia-Pacific Association for the Study of Liver(APASL)definitions of acute-on-chronic liver failure(ACLF)in predicting short-term prognosis of patients with ACLF.METHODS:Consecutive patients of cirrhosis with acute decompensation were prospectively included.They were grouped into ACLF and no ACLF groups as per CLIF-SOFA and APASL criteria.Patients were followed up for 3 mo from inclusion or mortality whichever was earlier.Mortality at 28-d and 90-d was compared between no ACLF and ACLF groups as per both criteria.Mortality was also compared between different grades of ACLF as per CLIF-SOFA criteria.Prognostic scores like CLIF-SOFA,Acute Physiology and ChronicHealth Evaluation(APACHE)-Ⅱ,Child-Pugh and Model for End-Stage Liver Disease(MELD)scores were evaluated for their ability to predict 28-d mortality using area under receiver operating curves(AUROC).RESULTS:Of 50 patients,38 had ACLF as per CLIFSOFA and 19 as per APASL criteria.Males(86%)were predominant,alcoholic liver disease(68%)was the most common etiology of cirrhosis,sepsis(66%)was the most common cause of acute decompensation while infection(66%)was the most common precipitant of acute decompensation.The 28-d mortality in no ACLF and ACLF groups was 8.3%and 47.4%(P=0.018)as per CLIF-SOFA and 39%and 37%(P=0.895)as per APASL criteria.The 28-d mortality in patients with no ACLF(n=12),ACLF grade 1(n=11),ACLF grade 2(n=14)and ACLF grade 3(n=13)as per CLIF-SOFA criteria was 8.3%,18.2%,42.9%and76.9%(χ2 for trend,P=0.002)and 90-d mortality was 16.7%,27.3%,78.6%and 100%(χ2 for trend,P<0.0001)respectively.Patients with prior decompensation had similar 28-d and 90-d mortality(39.3%and 53.6%)as patients without prior decompensation(36.4%and 63.6%)(P=NS).AUROCs for 28-d mortality were 0.795,0.787,0.739 and 0.710 for CLIF-SOFA,APACHE-Ⅱ,Child-Pugh and MELD scores respectively.On multivariate analysis of these scores,CLIF-SOFA was the only significant independent predictor of mortality with an odds ratio 1.538(95%CI:1.078-2.194).CONCLUSION:CLIF-SOFA criteria is better than APASL criteria to classify patients into ACLF based on their prognosis.CLIF-SOFA score is the best predictor of short-term mortality. | Radha K Dhiman Swastik Agrawal Tarana Gupta Ajay Duseja Yogesh Chawla | 2014 | World Journal of Gastroenterology2014，20，40： | 26 |
| 2 | Effect of rare earth(Er,Gd,Eu,Nd and La) and bismuth additives on the mechanical and piezoelectric properties of lead zirconate titanate ceramics显示文摘 | AJAI GARG AGRAWAL D C | 2001 | Mater Sci Eng2001，86，： | 1 |
| 3 | Gone but not forgotten : knowledge flows, labor mobility, and enduring social relationships 显示文摘 | Ajay Agrawal lain Cockbum and John McHale | 2006 | Journal of Economic Geography2006，，6： | 1 |
| 4 | Investigation of a Miniature Combustor Using Porous Media Surface Stabilized Flame显示文摘 | Timothy L Marbach Ajay K Agrawal | 2007 | Combustion Science and Technology2007，179，9： | 1 |
| 5 | Coupling terahertz radiation onto a metal wire using a subwavelength coasxial aperture显示文摘 | Amit Agrawal Ajay Nahata | 2007 | Optics Express2007，15，14： | 1 |
| 6 | Antibody-Mediated Targeting of Long-Circulating (Stealth<sup>R</sup>) Liposomes显示文摘 | Theresa M. Allen Ajay K. Agrawal Imran Ahmad Christian B. Hansen Samuel Zalipsky | 1994 | Journal of Liposome Research1994，，1： | 1 |
| 7 | Coupling terahertz radiation onto a metal wire using a snbwavelength coasxial aperture 显示文摘 | Amit Agrawal Ajay Nahata | 2007 | Optics Express2007，15，14： | 1 |
| 8 | University-to-industry Knowledge Transfer: Lit- erature Review and Unanswered Questions 显示文摘 | Ajay Agrawal | 2003 | International Jour- nal of Management Reviews2003，，4： | 1 |
| 9 | Some simple economics of crowdfunding显示文摘 | AJAY AGRAWAL CHRISTIAN CATALINI AVI GOLDFARB | 2013 | Social Science Electronic Publishing2013，，： | 1 |
| 10 | The Simple Eeonomies of Crowdfunding 显示文摘 | Ajay Agrawal Christian Catalini Avi Goldfarb | 2013 | Poliey and Economy2013，，14： | 1 |
| 11 | Gravitational effects on near-field flow structure of low-density gas jets显示文摘 | Tze Wing Yep Ajay K Agrawal De Von Griffin | 2003 | AIAA Journal2003，41，10： | 1 |
| 12 | University-to-industry knowledge transfer: literature review and unanswered questions 显示文摘 | Ajay Agrawal | 2003 | International Journal of Management Reviews2003，4，： | 1 |
| 13 | Coupling terahertz radiation onto a metal wire using a subwavelength coasxial aperture显示文摘 | Amit Agrawal Ajay Nahata | 2007 | Optics Express2007，15，14： | 1 |
| 14 | The Simple Economics of Crowdfunding显示文摘 | Ajay Agrawal Christian Catalini Avi Goldfarb | 2013 | Policy and Economy2013，，14： | 1 |
| 15 | Putting patents in context:exploring knowledge transfer from MIT 显示文摘 | AJAY AGRAWAL REBECCA HENDERSON | 2002 | Management Science2002，48，1： | 1 |
| 16 | Study of Autoignition of Natural Gas in Diesel Environments Using Computational Fluid Dynamics with Detailed Chemical Kinetics显示文摘 | Hongfeng B I Ajay K Agrawal | 1998 | Combustion and Flame1998，113，： | 1 |
| 17 | Bias corrections of CartoDEM using ICESat-GLAS data in hilly regions显示文摘 | RASTOGI G AGRAWAL R AJAI | 2015 | GIScience&Remote Sensing2015，52，5： | 1 |
| 18 | A novel spectral analysis algorithm to obtain local scalar field statistics from line-of-sight measurements in turbulent flows显示文摘 | Pankaj S Kolhe Ajay K Agrawal | 2009 | Measurement Science and Technology2009，20，11： | 1 |
| 19 | Effect of rare earth (Er, Gd, Eu, Nd and La) and bismuth additives on the mechanical and piezoelectric properties of lead zirconate titanate ceramic显示文摘 | Garg Ajai Agrawal D C | 2001 | Mater Sci Eng2001，86，： | 1 |
| 20 | Coupling terahertz radiation onto a metal wire using a subwavelength coasxial aperture 显示文摘 | Amit Agrawal Ajay Nahata | 2007 | Optics Express2007，15，14： | 1 |
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