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| 1 | 辛酰溴苯腈与2,4-D丁酯混用后对鸭跖草联合作用的研究显示文摘在温室盆栽条件下 ,采用等效线法评价辛酰溴苯腈与 2 ,4-D丁酯混用后的联合作用类型。结果表明 ,二者混用对 3~ 4叶期鸭跖草 (CommelinacommunisL .) | 杨玉廷 林长福 耿贺利 孙宝祥 William H. Ahrens 牟敦桃 卜勤志 | 2001 | 农药2001，40，7： | 7 |
| 2 | Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome显示文摘Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer tran scription factor con sisti ng of 2 sub units, HIF-1α and HIF-1β. Hypoxia-depe ndent activatio n of HIF-1α regulates cellular 02 homeostasis. Raynaud syndrome (RS), as a comorbidity of the autoimmune disease systemic sclerosis (SS), is characterized by vasospasms that limit blood flow to the limbs, resulting in hypoxia. A single-center randomized study was con ducted to compare prostagla ndin E1 (PgEI) therapy with a treatme nt combi ning PgE1 and an en dotheli n-1 blocker, bosentan. A total of 30 patients suffering from SS with RS were enrolled. We examined the regulation of HIF-1α, its target heme oxygenase-1 (HMOX-1), and the serum levels of the HIF-1α protein in a subset of patients as well as in ten healthy individuals. The expression of HIF-1α and HMOX-1 in monocytes was measured using absolute plasmid-based quantitative real-time PCR, whereas serum HIF-1α levels were measured with ELISA. Samples were taken at the time of randomization and after 24 weeks. We found that HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels were significantly higher in the SS/RS patients compared to the healthy control group. Single-drug therapy significantly increased HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels in the SS/RS patients compared to those at the time of randomization, whereas combining PgE1 with an en dotheli n-1 blocker preve nted the further in creases in HIF-1α and HMOX-1 expressi on. We propose HIF-1α and HMOX-1 as novel markers for anti-ischemic therapy in RS. | Lukas Andreas Heger Mark Kerber Marcus Hortmann Samuel Robinson Maximilian Mauler Daniela Stallmann Daniel Duerschmied Christoph Bode Christoph Hehrlein Ingo Ahrens | 2019 | Acta Pharmacologica Sinica2019，40，4： | 5 |
| 3 | Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients显示文摘miRNAs 为尖锐心肌的梗塞(AMI ) 作为潜在的 biomarkers 显示出诺言。然而,当前的使用的量的即时 PCR (qRT-PCR ) 完全为 nucleic 酸的相对表示允许,它产生日常可变性,它限制了把 miRNAs 用作 biomarkers 的有效性。在这研究,我们探索了技术质量和一种新技术的诊断潜力,基于薄片的数字 PCR,在确定在有 AMI 和 ischaemia-reperfusion 损害(I/R ) 的病人的 miRNAs。在合成 C.elegans-miR-39 的一个冲淡系列,基于薄片的数字 PCR 与 qRT-PCR 相比显示了变化(8.9% 对 46.3%) 和察觉(0.2 copies/L 对 1.1 copies/L ) 的更低的限制的一个更低的系数。在从有圣举起心肌的梗塞( STEMI )的 24 个病人和有稳定的冠的动脉疾病( CAD )的 20 个病人镇定的浆液在经皮的冠的干预(一种总线标准)以后的病人,我们使用了 qRT-PCR 和多路的基于薄片的数字 PCR 确定他们在优先的研究在 AMI 被验证了的 miRNA-21 和 miRNA-499 的浆液层次。在 STEMI, I/R 损害经由圣片断分辨率(ST-R ) 的测量被估计。基于薄片的数字 PCR 处于在稳定的 CAD 和 STEMI 组之间的 miR-21 层次的差别揭示了统计意义(118.8 copies/L 对 59 copies/L;P=0.0300 ) ,而 qRT-PCR 是不能的到达意义(136.4 copies/L 对 122.8 copies/L;P=0.2273 ) 。为 miR-499 层次,基于薄片的数字 PCR 和 qRT-PCR 揭示了稳定的 CAD 和 STEMI 组之间的统计上重要的差别(2 copies/L 对 8.5 copies/L, P=0.0011;0 copies/L 对 19.4 copies/L;P < 0.0001 ) 。在 miR-21/499 层次和 ST-R 之间没有协会一种总线标准以后。我们的结果证明基于薄片的数字 PCR 展出优异技术质量和诺言是一个优异方法因为确定的 miRNA 在发行量铺平,它可以为直接确定成为一个更精确、可再现的方法 miRNAs,特别地为在大多中心的使用临床的试用。 | Samuel ROBINSON Marie FOLLO David HAENE Maximilian MAULER Daniela STALLMANN Lukas Andreas HEGER Thomas HELBING Daniel DUERSCHMIED Karlheinz PETER Christoph BODE Ingo AHRENS Marcus HORTMANN | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 4 | Cell Stem Cell:利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展显示文摘在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞(iPS细胞)制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此,这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为"Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro". | Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu | 2016 | 现代生物医学进展2016，0，32： | 4 |
| 5 | New fossil evidence of the early diversification of scarabs: AIIoioscarabaeus cheni (Coleoptera: Scarabaeoidea) from the Middle Jurassic of Inner Mongolia, China显示文摘 | Ming Bai Dirk Ahrens Xing-Ke Yang Dong Ren | 2012 | Insect Science2012，19，2： | 3 |
| 6 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 7 | Determination of polyfluoroalkyl compounds in water and suspended particulate matter in the river Elbe and North Sea,Germany显示文摘The distribution of polyfluoroalkyl compounds(PFCs)in the dissolved and particulate phase and their discharge from the river Elbe into the North Sea were studied.The PFCs quantified included C_(4)-C_(8) perfluorinated sulfonates(PFSAs),6∶2 fluorotelomer sulfonate(6∶2 FTS),C_(6) and C_(8) perfluorinated sulfinates(PFSiAs),C_(4)-C_(12) perfluorinated carboxylic acids(PFCAs),perfluoro-3,7-dimethyl-octanoic acid(3,7m_(2)-PFOA),perfluorooctane sulfonamide(FOSA),and n-ethyl perfluroctane sulfonamidoethanol(EtFOSE).PFCs were mostly distributed in the dissolved phase,where perfluorooctanoic acid(PFOA)dominated with 2.9–12.5 ng/L.In the suspended particulate matter FOSA and perfluorooctane sulfonate(PFOS)showed the highest concentrations(4.0 ng/L and 2.3 ng/L,respectively).The total flux ofΣPFCs from the river Elbe was estimated to be 802 kg/year for the dissolved phase and 152 kg/year for the particulate phase.This indicates that the river Elbe acts as a source of PFCs into the North Sea.However,the concentrations of perfluorobutane sulfonate(PFBS)and perfluorobutanoic acid(PFBA)in the North Sea were higher than that in the river Elbe,thus an alternative source must exist for these compounds. | Lutz AHRENS Merle PLASSMANN Zhiyong XIE Ralf EBINGHAUS | 2009 | Frontiers of Environmental Science & Engineering2009，3，2： | 3 |
| 8 | The importance of a β-glucan receptor in the nonopsonic entry of nontypeable Haemophilus influenzae into human monocytic and epithelial cells显示文摘 | Ahren IL William DL Rice PJ | 2001 | J Infect Dis2001，184，2： | 2 |
| 9 | Structure and Rare-Earth Magnetism in (Nd1-xGdx)2CuO4 显示文摘 | Adelmann P Ahrens R Czjzek G | 1992 | Phys Rev B1992，46，： | 2 |
| 10 | The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin显示文摘 | Simon R. Smukler Margot E. Arntfield Rozita Razavi George Bikopoulos Phillip Karpowicz Raewyn Seaberg Feihan Dai Simon Lee Rosemary Ahrens Paul E. Fraser Michael B. Wheeler Derek van der Kooy | 2011 | Cell Stem Cell2011，，3： | 2 |
| 11 | A Machine Learning Method for Prediction of Multipath Channels显示文摘A machine learning method for predicting the evolution of a mobile communication channel based on a specific type of convolutional neural network is developed and evaluated in a simulated multipath transmission scenario.The simulation and channel estimation are designed to replicate real-world scenarios and common measurements supported by reference signals in modern cellular networks.The capability of the predictor meets the requirements that a deployment of the developed method in a radio resource scheduler of a base station pos es.Possible applications of the method are discussed. | Julian AHRENS Lia AHRENS Hans DSCHOTTEN | 2019 | ZTE Communications2019，17，4： | 2 |
| 12 | Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line ( INS - 1 cell) 显示文摘 | Ahren B Havel PJ | 1999 | AM J Physiol1999，277，42： | 1 |
| 13 | Predictors of bad and good outcome of lumbar spine surgery:a prospective clinical study with 2 years′ follow-up显示文摘 | Junge A Frohlich M Ahrens S | 1996 | Spine1996，21，9： | 1 |
| 14 | The High fat diet-fed Nouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes显示文摘 | Winzell M S Ahren B | 2004 | Diabetes2004，53，3： | 1 |
| 15 | Leptin concentrations are increased in subjects treated with clozapine or conventional antipsychotics 显示文摘 | Soderberg S Ahren B | 2001 | J Clin Psychiatry2001，62，： | 1 |
| 16 | Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil 显示文摘 | Selbst MK Ahrens WA Robert ME | 2009 | Modem Pathology2009，22，6： | 1 |
| 17 | Treatment options for recurrent giant cell tumors of bone 显示文摘 | Balke M Ahrens H Streitbuerger A | 2009 | J Cancer Res Clin Oneol2009，135，： | 1 |
| 18 | Inhibition ofdipeptidyl peptidase 4 improves metabolic control over a 4-Weekstudy period in type 2 diabetes 显示文摘 | AHREN B SIMONSSON E LARSSON H | 2002 | Diabetes Care2002，25，5： | 1 |
| 19 | The fractal mind of pedal- ogists ( soil taxonomists and soil surveyors) 显示文摘 | Ibanez J J Arnold R W Ahrens R J | 2009 | Ecological Com- plexity2009，6，： | 1 |
| 20 | The silent epidemic a- mong Wisconsin women:chronic obstructive pulmonary disease trends, 1980-2000 显示文摘 | Edwards N M Umland M Ahrens D | 2005 | WMJ2005，104，4： | 1 |
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