4篇
您的检索式：作者名="Adrian Sanchez"
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| 1 | Successes and challenges of HIV prevention in men who have sex with men显示文摘 | Patrick S Sullivan Alex Carballo-Diéguez Thomas Coates Steven M Goodreau Ian McGowan Eduard J Sanders Adrian Smith Prabuddhagopal Goswami Jorge Sanchez | 2012 | 2012 (9839)2012，，9839： | 1 |
| 2 | Effect of modified montmorillonite on biodegradable PHB nanocomposites显示文摘 | Adrian Botana Mariana Mollo Patricia Eisenberg Rosa M. Torres Sanchez | 2009 | Applied Clay Science2009，，3： | 1 |
| 3 | 井眼地震测量:超越垂直剖面显示文摘当前的井眼地震技术为研究井眼钻穿的地层提供了新的机会。从建井与三维盐下成像到增产措施监测和高温、高压采集,井眼地震测量都可以帮助作业公司降低作业风险,提高采收率。 | John Blackburn John Daniels Scott Dingwall Geoffrey Hampden-Smith Scott Leaney Joel Le Calvez Les Nutt Henry Menkiti Adrian Sanchez Marco Schinelli | 2008 | 国外测井技术2008，23，6： | 0 |
| 4 | Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson’s disease:removing axonal debris显示文摘Objective:The dopaminergic nigrostriatal neurons(DA cells)in healthy people present a slow degeneration with aging,which produces cellular debris throughout life.About 2%-5%of people present rapid cell degeneration of more than 50%of DA cells,which produces Parkinson's disease(PD).Neuroinflammation accelerates the cell degeneration and may be critical for the transition between the slow physiological and the rapid pathological degeneration of DA cells,particularly when it activates microglial cells of the medial forebrain bundle near dopaminergic axons.As synaptic debris produced by DA cell degeneration may trigger the parkinsonian neuroinflammation,this study investigated the removal of axonal debris produced by retrograde degeneration of DA cells,paying particular attention to the relative roles of astrocytes and microglia.Methods:Rats and mice were injected in the lateral ventricles with 6-hydroxydopamine,inducing a degeneration of dopaminergic synapses in the striatum which was not accompanied by non-selective tissue damage,microgliosis or neuroinflammation.The possible retrograde degeneration of dopaminergic axons,and the production and metabolization of DA-cell debris were studied with immunohistochemical methods and analyzed in confocal and electron microscopy images.Results:The selective degeneration of dopaminergic synapses in the striatum was followed by a retrograde degeneration of dopaminergic axons whose debris was found within spheroids of the medial forebrain bundle.These spheroids retained mitochondria and most(e.g.,tyrosine hydroxylase,the dopamine transporter protein,and amyloid precursor protein)but not all(e.g.,α-synuclein)proteins of the degenerating dopaminergic axons.Spheroids showed initial(autophagosomes)but not late(lysosomes)components of autophagy(incomplete autophagy).These spheroids were penetrated by astrocytic processes of the medial forebrain bundle,which provided the lysosomes needed to continue the degradation of dopaminergic debris.Finally,dopaminergic proteins were observed in the cell somata of astrocytes.No microgliosis or microglial phagocytosis of debris was observed in the medial forebrain bundle during the retrograde degeneration of dopaminergic axons.Conclusions:The present data suggest a physiological role of astrocytic phagocytosis of axonal debris for the medial forebrain bundle astrocytes,which may prevent the activation of microglia and the spread of retrograde axonal degeneration in PD. | Ingrid Morales Ricardo Puertas-Avendaño Alberto Sanchez Adrian Perez-Barreto Clara Rodriguez-Sabate Manuel Rodriguez | 2021 | Translational Neurodegeneration2021，10，4： | 0 |
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