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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 4 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 3 |
| 5 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 2 |
| 6 | Anaerobic treatment of pinkwater in a fluidized bed reactor containing GAC 显示文摘 | Stephon W M Adrian N R Hickey R F | 2002 | Journal of Hazardous Materials2002，92，1： | 1 |
| 7 | Daniel A highly stable pullulanase from Thermus a quaticus YT-I显示文摘 | Adrian R Plant Hugh W Morgan Roy M | 1986 | En- zyme and Microbial Technology1986，8，11： | 1 |
| 8 | Concentrations and mass fluxes of chloroacetic acids and trifluoroacetic acid in rain and natural waters in Switzerland显示文摘 | MICHEAL B STEPHAN R M ADRIAN W | 2000 | Environ Sci Technol2000，34，： | 1 |
| 9 | Development of a pavement rutting model from experimental data显示文摘 | ADRIAN R A SAMER M | 2000 | Journal of Transportation Engineering(ASCE)2000，126，4： | 1 |
| 10 | Decentralized generation of electricity with solid oxide fuel cells from centrally converted biomass显示文摘 | Toonssen R Woudstra N Adrian H M | 2010 | International Journal of Hydrogen Energy2010，35，： | 1 |
| 11 | HPLC analysis of grapevine phytoalexins coupling photodiode array detection and fluorometry显示文摘 | JEANDET P BREUIL A C ADRIAN M WESTON L A DEBORD S MEUNIER P MAUME G BESSIS R | 1997 | Analytical Chemistry1997，69，24： | 1 |
| 12 | Anaerobic bioaansformation of explosives in aquifer slurries amended with ethanol and propylene glycol显示文摘 | ADRIAN N R ARNETT C M | 2007 | Chemosphere2007，66，10： | 1 |
| 13 | Structure of the Crypto- sporidium parvum microneme:a metabolically and osmotically labile apieomplexan organelle显示文摘 | Harris J R Adrian M Petry F | 2003 | Micron2003，34，： | 1 |
| 14 | Magnetic signature of daily sampled urban atmospheric particles显示文摘 | Adrian R M Jurgen M Alfonso F D | 2003 | Atmospheric Environment2003，37，29： | 1 |
| 15 | Comparison of magnetic parameters of urban atmospheric particulate matter with pollution and meteorologicaldata显示文摘 | Adrian R M Jtirgen M Nikolai P | 2001 | Atmospheric Environment2001，35，26： | 1 |
| 16 | Lakes as sentinels of climate change显示文摘 | ADRIAN R O'REILLY C M ZAGARESE H | 2009 | Limnology and Oceanography2009，54，6： | 1 |
| 17 | Lakes as sentinelsof climate change显示文摘 | Adrian R O’Reilly C M Zagarese H | 2009 | Limnology and Oceanography2009，54，62： | 1 |
| 18 | Phytoalexins from the Vitaceae:biosynthesis,phytoalexin gene expression in transgenic plants,antifungal activity and metabolism显示文摘 | JEANDET P DOUILLET-BREUIL A C BESSIS R DEBORD S SBAGHI M ADRIAN M | 2002 | J Agric Food Chem2002，50，： | 1 |
| 19 | Evaluating the basidiomycetes Poriamedula-pani and Wolfiporia cocos for xylanase production显示文摘 | Adriane M F Milagres R M Sales E | 2001 | Enzyme and Microbial Technology2001，28，6： | 1 |
| 20 | Does allowing the sale of winein Quebec grocery stores increase consumption显示文摘 | ADRIAN M JEANDET P BESSIS R | 1996 | Agric Food Chem1996，44，： | 1 |
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