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| 1 | Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. | Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，1： | 2 |
| 2 | Reducing costly falls after total knee arthroplasty显示文摘AIM To investigate whether adductor canal nerve block(ACB) reduces patient falls when compared to femoral nerve block(FNB) after total knee arthroplasty(TKA). METHODS We conducted an institutional review of all-cause falls after TKA from January 2013 to August 2016 using a quality improvement database. Our inclusion criteria were patients with diagnosis of primary knee osteoarthritis who underwent primary unilateral TKA with either a FNB or an ACB and sustained a fall during their hospitalization. We excluded patients who had revision TKA and extensor mechanism reconstruction. We also excluded patients with a history of post-traumatic arthritis, prior history of lower extremity fracture, history of neurological disease, or cerebrovascular disease. RESULTS A total of 834 patients had TKA with femoral nerve block and knee immobilizer(FNB + KI). Of those patients, 11(1.3%) experienced a fall during their hospital stay. In contrast, 791 patients had TKA with ACB. Of those patients, only one(0.13%) patient fall was recorded within this group. We used the Fisher's exact test to compare the differences between the two groups. The difference between the two groups achieves statistical significance(P = 0.006). We also found that 11 out of the 12 patients that fell had a right TKA procedure while one patient had a left TKA procedure. Nine out of twelve patients that fell were female, while only three patients were male.CONCLUSION Given the reduction in the number of falls with ACB, it is recommended that ACB be considered the preferred analgesia for patients undergoing a TKA procedure. | Surajudeen Adebola Bolarinwa Wendy Novicoff Quanjun Cui | 2018 | World Journal of Orthopedics2018，9，10： | 2 |
| 3 | Economic Assessment and Review of Waterless Fracturing Technologies in Shale Resource Development: A Case Study显示文摘Our database tracking of USA water usage per well indicates that traditionally shale operators have been using, on average 3 to 6 million gallons of water; even up to 8 million for the entire life cycle of the well based on its suitability for re-fracturing to stimulate their long and lateral horizontal wells. According to our data, sourcing, storage, transportation, treatment, and disposal of this large volume of water could account for up to 10% of overall drilling and completion costs. With increasingly stringent regulations governing the use of fresh water and growing challenges associated with storage and use of produced and flowback water in hydraulic fracturing, finding alternative sources of fracturing fluid is already a hot debate among both the scientific community and industry experts. On the other hand, waterless fracturing technology providers claim their technology can solve the concerns of water availability for shale development. This study reviews high-level technical issues and opportunities in this challenging and growing market and evaluates key economic drivers behind water management practices such as waterless fracturing technologies, based on a given shale gas play in the United States and experience gained in Canada. Water costs are analyzed under a variety of scenarios with and without the use of(fresh) water. The results are complemented by surveys from several oil and gas operators. Our economic analysis shows that fresh water usage offers the greatest economic return. In regions where water sourcing is a challenge, however, the short-term economic advantage of using non-fresh water-based fracturing outweighs the capital costs required by waterless fracturing methods. Until waterless methods are cost competitive, recycled water usage with low treatment offers a similar net present value(NPV) to that of sourcing freshwater via truck, for instance. | Iman Oraki Kohshou Reza Barati Meaghan Cassey Yorro Tim Leshchyshyn Adebola T. Adejumo Usman Ahmed Imre Kugler Murray Reynolds James McAndrew | 2017 | Journal of Earth Science2017，28，5： | 2 |
| 4 | Prevalence of ven- trieular arrhythmias and heart rate variability pattern in chron- ic heart failure显示文摘 | Lasisi GT Adebola AP Ogah OS | 2012 | Niger Postgrad Med J2012，19，3： | 1 |
| 5 | Medium-Pressure clathrate hydrate/membrane hybrid process for postcombustion capture of carbon dioxide显示文摘 | PRAVEEN LINGA ADEBOLA ADEYEMO PETER ENGLEZOS | 2008 | Environ Sci Technol2008，42，1： | 1 |
| 6 | Effect of lead exposure on liver lipid peroxidative and antioxidant defense systems of protein-undernourished rats显示文摘 | Bukunola Oluyemisi Adegbesan Gbenga Adebola Adenuga | 2007 | Biological Trace Element Research2007，，2： | 1 |
| 7 | Regression Equations for Predicting the Effect of Tine Width on Draught and Soil Translocation in Moderately Fine Textured Soil显示文摘 | Seth Idowu Manuwa Olugboyega Cornelius Ademosun Adebola Adesina | 2012 | Journal of Environmental Science and Engineering(B)2012，1，6： | 1 |
| 8 | Prevalence of ventricular ar- rhythmias and heart rate variability pattern in chronic heart failure 显示文摘 | Lasisi GT Adebola AP Ogah OS | 2012 | Niger Postgrad Med J2012，19，3： | 1 |
| 9 | Essential oil composi-tion of three Zanthoxylum species显示文摘 | Oyedeji Adebola O Lawal* | 2008 | Journal of EssentialOil Research2008，20，1： | 1 |
| 10 | Perioperative manage- ment of obstructive sleep apnea 显示文摘 | Adebola O Adesanya S Won L | 2010 | Chest2010，138，6： | 1 |
| 11 | Characterization and evaluation of South African sweet potato ( Ipomoea batatas (L.) LAM) land races显示文摘 | S.M. Laurie F.J. Calitz P.O. Adebola A. Lezar | 2013 | South African Journal of Botany2013，，： | 1 |
| 12 | Synbiotics : the impact of potential prebiotics inulin, lactulose and lactobionic acid on the survival and growth of lactobacilli probiotics显示文摘 | Adebola O O Corcoran O Morgan W A | 2014 | Journal of Functional Foods2014，10，： | 1 |
| 13 | Genetic variability studies in the germplasm collection of kola (Cola nitida Schott and Endlicher)in South Western Nigeria显示文摘 | Adebola P O Aliyu O M Badaru K | 2002 | Plant Genetic Resources Newsletter2002，132，： | 1 |
| 14 | Molecular characterization of the genetic lesion in Dystonia musculorum (dt-Alb) mice显示文摘 | Goryunov D Adebola A Jefferson J J | 2007 | Brain Res2007，1140，： | 1 |
| 15 | Development and optimization of a process for automated recovery of single cells identified by microengraving显示文摘 | Jae HyeokChoi Adebola O.Ogunniyi MindyDu MinnaDu MarcelKretschmann JensEberhardt J. ChristopherLove | 2010 | Biotechnol Progress2010，，3： | 1 |
| 16 | The status of Cola germplasm and its conservation in Nigeria显示文摘 | Adebola P O Badaru K | 2003 | Plant Genetic Resources Newsletter2003，136，： | 1 |
| 17 | Principal component analysis of variation pattern among Cola nitida,Cola acuminata(Sterculiaceae)and their interspecific hybrids显示文摘 | Adebola P O | 2000 | Feddes Repertorium III2000，，34： | 1 |
| 18 | Prevalence of ventric- ular arrhythmias and heart rate variability pattern in chronic heart failure显示文摘 | Lasisi GT Adebola AP Ogah OS | 2012 | Niger Postgrad Med J2012，19，3： | 1 |
| 19 | Management of in- flammatory complications in third molar surgery: a review of the literature显示文摘 | Osunde O D Adebola R A Omeje U K | 2011 | Afr Health Sci2011，11，3： | 1 |
| 20 | Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation显示文摘 | Ognjen Gajic Saqib I. Dara Jose L. Mendez Adebola O. Adesanya Emir Festic Sean M. Caples Rimki Rana Jennifer L. St. Sauver James F. Lymp Bekele Afessa Rolf D. Hubmayr | 2004 | Critical Care Medicine2004，，9： | 1 |
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