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| 1 | ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: what is the way forward?显示文摘Pancreatic ductal adenocarcinoma(PDAC) is one of the most aggressive diseases and is characterized by high chemoresistance, leading to the lack of effective therapeutic approaches and grim prognosis. Despite increasing understanding of the mechanisms of chemoresistance in cancer and the role of ATPbinding cassette(ABC) transporters in this resistance, the therapeutic potential of their pharmacological inhibition has not been successfully exploited yet. In spite of the discovery of potent pharmacological modulators of ABC transporters, the results obtained in clinical trials have been so far disappointing, with high toxicity levels impairing their successful administration to the patients. Critically, although ABC transporters have been mostly studied for their involvement in development of multidrug resistance(MDR), in recent years the contribution of ABC transporters to cancer initiation and progression has emerged as an important area of research, the understanding of which could significantly influence the development of more specific and efficient therapies. In this review, we explore the role of ABC transporters in the development and progression of malignancies, with focus on PDAC. Their established involvement in development of MDR will be also presented. Moreover, an emerging role for ABC transporters as prognostic tools for patients' survival will be discussed, demonstrating the therapeutic potential of ABC transporters in cancer therapy. | Aleksandra Adamska Marco Falasca | 2018 | World Journal of Gastroenterology2018，24，29： | 3 |
| 2 | Identification of genes expressed in response to light 8tress in leaves of Arabidopsis thaliana using RNA differential display显示文摘 | Dunaeva M Adamska I | 2001 | Eur Biochem2001，268，21： | 1 |
| 3 | Synthesis of linear and cyclic opioid-based peptide analogs containing multiple N-methylated amino acid residues显示文摘 | Adamska A Kolesi fi ska B Kluczyk A | 2015 | J Pept Sci2015，21，11： | 1 |
| 4 | Insulin sensitivity,metabolic flexibility,and seruma diponectin concentration in women with anorexia nervosa显示文摘 | Karczewska-Kupczewska M Straczkowski M Adamska A Nikoyajuk A Otziomek E Górska M Kowalska I | | 0，，： | 1 |
| 5 | Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria 显示文摘 | Huesgen PF Schuhmann H Adamska I | 2009 | Research in Microbiolo- gy2009，160，： | 1 |
| 6 | 显示文摘 | Kaczmarek Z Adamska E Cegielska 丁 | 2008 | Industrial Cropsand Products2008，27，： | 1 |
| 7 | Deg/HtrA proteases as components of a network for photosystem 11 quality control in chloroplasts and cyanobacteria 显示文摘 | Huesgen PF Schuhmann H Adamska I | 2009 | Res Microbiol2009，160，9： | 1 |
| 8 | Hansen Solubility Parameters for Polyethylene Glycols by Inverse Gas Chromatography显示文摘 | Adamska K Voelkel A | | 0，，1： | 1 |
| 9 | UV light stress induces the synthesis of the early light-inducible protein and prevents its degradation 显示文摘 | ADAMSKA I KLOPPSTECH K OHAD I | 1992 | The Journal of Biological Chemis1992，267，24： | 1 |
| 10 | Biology, epidemio- logy and diagnostics of pathogenic waterborne protozoan parasites显示文摘 | LEONSKA-DUNIEC A ADAMSKA M | 2010 | Wiad Parazytol2010，56，2： | 1 |
| 11 | 查看详情显示文摘 | Adamska K Bellinghausen R Voelkel A | | 0，，： | 1 |
| 12 | Serum retinol binding protein 4 is related to insulin resistance and non-oxidative glucose metabolism in lean and obese women with normal glucose tolerance显示文摘 | IRINA MS ADAMSKA A | | 0，，： | 1 |
| 13 | Epoxide hydrolases:structure,function,mechanism,and assay显示文摘 | Arand M Cronina Adamska M | 2005 | Methods Enzymol2005，400，： | 1 |
| 14 | Inverse gas chromatography as a source of physiochemical data 显示文摘 | VOELKEL A STRZEMIECKA B ADAMSKA K | 2009 | JChromatogrA2009，1216，： | 1 |
| 15 | 查看详情显示文摘 | Voelkel A Strzemiecka B Adamska K | | 0，，10： | 1 |
| 16 | Indices of vascular stiffness and wave reflection in relation to body mass index or body fat in healthy subjeets显示文摘 | Wykretowicz A Adamska K Guzik P | 2007 | Clin Exp Pharmacol Physiol2007，34，： | 1 |
| 17 | 查看详情显示文摘 | Adamska K Voelkel A | | 0，，1： | 1 |
| 18 | Assessment of genetic effects on important breeding traits in reciprocal DH populations of winter oilseed rape (Brassica napus L.)显示文摘Here we present a study on the genetic effects of agronomic and seed quality traits in double haploid(DH) populations,which were developed by microspore culture from reciprocal F1 hybrids produced between cultivar Californium and DH W-15.Each of the populations consisted of 25 DH lines.The field experiments were conducted in a randomized complete block design with three replications during three growing seasons.Field observations were recorded on seed yield and its structure: the number of branches and pods per plant,the number of seeds per pod,the 1 000-seed weight,the content of fat in the seeds,and three unsaturated fatty acids(oleic,linoleic,linolenic) in the seed oil.In order to investigate the influence of cross direction on the studied traits,parental effects were evaluated on the basis of differences between reciprocal DH populations.The maternal effect was revealed on the number of seeds per pod and the effect of the paternal form on linolenic acid content.The occurrence of transgression effects also depended on the direction of crossing and this was particularly noticeable in terms of the number of seeds per pod.The use of multivariate statistical methods allowed for the simultaneous characterization and grouping of tested lines in terms of several traits.Graphic images of the distribution of DH lines in the space of the two first canonical variates showed a great variation between the two reciprocal populations,both in terms of yield and its components,as well as fat and those unsaturated fatty acids. | Laurencja Szala Teresa Cegielska-Taras Elzbieta Adamska Zygmunt Kaczmarek | 2018 | Journal of Integrative Agriculture2018，17，1： | 1 |
| 19 | Hypomorphic expression of Dkk1 in the doubleridge mouse:dose dependence and compensatory interactions with Lrp6显示文摘 | MacDonald BT Adamska M Meisler MH | 2004 | Development2004，131，11： | 1 |
| 20 | Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome显示文摘 | Irina Kowalska Marek Straczkowski Agnieszka Nikolajuk Agnieszka Adamska Monika Karczewska-Kupczewska Elzbieta Otziomek Ida Kinalska Maria Gorska | 2008 | Metabolism2008，，11： | 1 |
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