|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities显示文摘Acute myocardial infarction(AMI) is the leading cause of death worldwide. Its associated mortality, morbidity and complications have significantly decreased with the development of interventional cardiology and percutaneous coronary angioplasty(PCA) treatment, which quick-ly and effectively restore the blood flow to the area previously subjected to ischemia. Paradoxi-cally, the restoration of blood flow to the ischemic zone leads to a massive production of reactive oxygen species(ROS) which generate rapid and severe damage to biomolecules, generating a phenomenon called myocardial reperfusion injury(MRI). In the clinical setting, MRI is associated with multiple complications such as lethal reperfusion, no-reflow, myocardial stunning, and reperfusion arrhythmias. Despite significant advances in the understanding of the mechanisms accounting for the myocardial ischemia reperfusion injury, it remains an unsolved problem. Although promising results have been obtained in experimental studies(mainly in animal models), these benefits have not been translated into clinical settings. Thus, clinical trials have failed to find benefits from any therapy to prevent MRI. There is major evidence with respect to the contribution of oxidative stress to MRI in cardiovascular diseases. The lack- of consistency between basic studies and clinical trials is not solely based on the diversity inherent in epidemiology but is also a result of the methodological weak-nesses of some studies. It is quite possible that pharmacological issues, such as doses, active ingredients, bioavailability, routes of administration, co-therapies, startup time of the drug intervention,and its continuity may also have some responsibility for the lack- of consistency between different studies. Furthermore, the administration of high ascorbate doses prior to reperfusion appears to be a safe and rational therapy against the development of oxidative damage associated with myocardial reperfusion. In addition, the association with N-acetylcysteine(a glutathione donor) and deferoxamine(an iron chelator) could improve the antioxidant cardioprotection by ascorbate, mak-ing it even more effective in preventing myocardial reperfusion damage associated with PCA following AMI. | Jaime González-Montero Roberto Brito Abraham IJ Gajardo Ramón Rodrigo | 2018 | World Journal of Cardiology2018，10，9： | 56 |
| 2 | Depression in patients with irritable bowel syndrome in Jos,Nigeria显示文摘AIM: To study the brain-gut interaction and the effect of behavioral or psychiatric conditions on irritable bowel syndrome (IBS) in an African population. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria. The entry of each patient was confirmed following detailed explanations of the questions. Four hundred and eighteen patients were studied. Subjects satisfying the Rome Ⅱ criteria for IBS were physically examined and stool microscopy was done to identify the presence of “alarm factors”. Depression was diagnosed using the symptom-check list adapted from the Research Diagnostic Criteria (DSM-Ⅳ) of the American Psychiatric Association. RESULTS: Seventy-five (56.8%) of the 132 IBS patients were depressed whereas only 54 (20.1%) of the 268 non-IBS patients were depressed. There was a significant relationship between IBS and depression (χ2 = 54.29, Odds ratio = 5.21, 56.8 ± 8.4 vs 20.1 ± 5.2, P = 0.001). Even though constipation predominant IBS patients were more likely to be depressed, no significant relationship was found between the subtype of IBS and depression (χ2 = 0.02, OR = 0.95, P = 0.68). CONCLUSION: IBS is significantly associated with major depression but not gender and bowel subtypes of the patients. Patients with IBS need to be evaluated for depression due to the highly significant relationship between the two conditions. | Nimzing G Ladep Taiwo J Obindo Moses D Audu Edith N Okeke Abraham O Malu | 2006 | World Journal of Gastroenterology2006，12，48： | 22 |
| 3 | WJSC 6^(th) Anniversary Special Issues(1):Hematopoietic stem cell transplantation Allogeneic hematopoietic cell transplant for acute myeloid leukemia:Current state in 2013 and future directions显示文摘Acute myeloid leukemia(AML)represents a heterogeneous group of high-grade myeloid neoplasms of the elderly with variable outcomes.Though remissioninduction is an important first step in the management of AML,additional treatment strategies are essential to ensure long-term disease-free survival.Recent pivotal advances in understanding the genetics and molecular biology of AML have allowed for a risk-adapted approach in its management based on relapse-risk.Allogeneic hematopoietic cell transplantation(allo-HCT)represents an effective therapeutic strategy in AML providing the possibility of cure with potent graft-versus-leukemia reactions,with a demonstrable survival advantage in younger patients with intermediate-or poor-risk cytogenetics.Herein we review the published data regarding the role of allo-HCT in adults with AML.We searched MEDLINE/PubMed and EMBASE/Ovid.In addition,we searched reference lists of relevant articles,conference proceedings and ongoing trial databases.We discuss the role of allo-HCT in AML patients stratified by cytogenetic-and molecular-risk in first complete remission,as well as allo-HCT as an option in relapsed/refractory AML.Besides the conventional sibling and unrelated donor allografts,we review the available data and recent advances for alternative donor sources such as haploidentical grafts and umbilical cord blood.We also discuss conditioning regimens,including reduced intensity conditioning which has broadened the applicability of allo-HCT.Finally we explore recent advances and future possibilities and directions of allo-HCT in AML.Practical therapeutic recommendations have been made where possible based on available data and expert opinion. | Abraham S Kanate Marcelo C Pasquini Parameswaran N Hari Mehdi Hamadani | 2014 | World Journal of Stem Cells2014，6，2： | 6 |
| 4 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 5 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 6 | The murine double- stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus 显示文摘 | Stojdl DF Abraham N Knowles S | 2000 | J Virol2000，74，20： | 1 |
| 7 | Processes in the Formation of Uhracold NaCs显示文摘 | ABRAHAM E R I RITCHIE N W M MCALEXANDER W I HULET R G | 1995 | J Chem Phys1995，103，： | 1 |
| 8 | Complications ofspinal anaesthesiaa prospective study of 5000 cases 显示文摘 | ABRAHAM A A RIYAN S MANJU N | 2010 | JAnaesth Clin Pharmacol2010，26，1： | 1 |
| 9 | Irrigation automationbased on soil electrical conductivity and leaf temperature 显示文摘 | ABRAHAM N HEMA P S SARITHA E K | 2000 | Agricultural Water Management2000，45，： | 1 |
| 10 | Absence of CNTNAP2 leads to epilepsy,neuronal migration abnormalities,and core autism-related deficits显示文摘 | Pe(n)agarikano O Abrahams BS Herman EI | | 0，，01： | 1 |
| 11 | Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘 | William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan | 2004 | Circulation2004，，18： | 1 |
| 12 | Maternal satis- faction as an outcome criterion in research on labor anal- gesia data analysis from the recent literature显示文摘 | Abraham N Miceli MC Parnes JR | 2015 | Clinical Journal of Pain2015，31，3： | 1 |
| 13 | Irrigation automation based on soil electrical conductivity and leaf temperature显示文摘 | Abraham N Hema P S Saritha E K | 2000 | Agricultural Water Management2000，45，： | 1 |
| 14 | Concurrent Coupling of Length Scales: Methodology and Application显示文摘 | Broughton J Q Abraham F F Bernstei N | 1999 | Phys Rev1999，60，： | 1 |
| 15 | Sexual violence against intimate partners in Cape Town:prevalence and risk factors reported by men显示文摘 | Abrahams N Jewkes R Hoffman M | 2004 | Bull World Health Organ2004，82，5： | 1 |
| 16 | Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereos-elective properties显示文摘 | Graf B M Abraham I Eberbach N | 2002 | Anesthesiology2002，96，6： | 1 |
| 17 | A preliminary assessment of genetic relationships among agronomically important cultivars of black pepper显示文摘 | joy N Abraham Z Soniya E V | 2007 | BMC Genetics2007，8，： | 1 |
| 18 | Mast eeU-orchestmted imrrmnity to pathogens 显示文摘 | Abraham S N St John A L | 2010 | Nat Rev Immunol2010，10，6： | 1 |
| 19 | HPV-DNA in plasmaof patients with cervical carcinoma显示文摘 | Sathish N Abraham P Peedicayil A | 2004 | J Clin Virol2004，31，3： | 1 |
| 20 | Dynamic fracture of silicon: concurrent simulation of quantum electrons, classical atoms, and the continuum solid 显示文摘 | Abraham F F Bernstein N Broughton J Q | 2000 | MRS Bulletin2000，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员