|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 2 | Sleep problems of elementary school children A community survey显示文摘 | Blader JC Koplewicz HS Abikoff H | 1997 | J Arch Pediatr Adolesc Med1997，151，： | 1 |
| 3 | Non - discrete groups of hyperbolis motions显示文摘 | Abikoff W Hass A | 1990 | Bull London Math Soc1990，22，： | 1 |
| 4 | Social functioning in chil- dren with ADHD treated with long-term methylpheni- date and multimodal psychosocail treatment显示文摘 | Abikoff H Hechtman L Klein RG | 2004 | J Am Acad Child Adolesc Psychiatry2004，43，6： | 1 |
| 5 | Stimulant Medications显示文摘 | Greenhill LL Halper JM Abikoff H | 1999 | J AM ACAD Child Adolesc Psychiatry1999，38，5： | 1 |
| 6 | Medication treatment strategies in the MTA Study: relevance to clinicians and researchers显示文摘 | Greenhill LL Abikoff HB Arnold LE | 1996 | J Am Acad Child Adolesc Psychiatry1996，35，10： | 1 |
| 7 | Design and rationale of con- trolled study of long-term methylphenidate and muhimodal psychosocial treatment in children with ADHD显示文摘 | Klein RG Abikoff H Hechtman L | 2004 | J Am Acad Child Adolesc Psychiatry2004，43，6： | 1 |
| 8 | Stimulant medications 显示文摘 | Greenhill LI Halperin J M Abikoff H | 1999 | Am Acad Child Adolesc Psychiatry1999，38，： | 1 |
| 9 | A randomized, doubleblind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD 显示文摘 | McGough JJ Wigal SB Abikoff H | 2006 | J Atten Disord2006，9，3： | 1 |
| 10 | Signi?cance of childhood conduct problems to later development of conduct disorder among children with ADHD:a prospective follow-up study显示文摘 | Mannuzza S Klein R.G Abikoff H Moulton J.L | | 0，，5： | 1 |
| 11 | Stimulant medications显示文摘 | Greenhill LL Halperin JM Abikoff H | 1999 | J Am Acad Child Adolesc Psychiatry1999，38，5： | 1 |
| 12 | Efficacy and safety of im- mediate-release methylphenidate treatment for preschoolers with ADHD 显示文摘 | Greenhi11L Kollins S Abikoff H | 2006 | J Am Acad Child Adolesc Psychiatry2006，45，11： | 1 |
| 13 | Significance of child hood conduct problems to later development of conduct disorder among children with ADHD: a prospective follow-up study显示文摘 | Mannuzza S Klein RG Abikoff H | 2004 | J Abnorm Child Psychol2004，32，5： | 1 |
| 14 | Stimulant Medications显示文摘 | Greenhill LL Halper JM Abikoff H | 1999 | J AM ACAD Child Adolesc Psychiatry1999，38，5： | 1 |
| 15 | Stimulant medications显示文摘 | Greenhill LL Halperin JM Abikoff H | 1999 | J Am Acad Child Adolesc Psychiatry1999，38，： | 1 |
| 16 | Medication treatment strantegies in the MTA Study: relevance to clinicians and researchers显示文摘 | Greenhill LL Abikoff HB Amold LE | 1996 | J Am Acad Child Adolesc Psychiatry1996，35，10： | 1 |
| 17 | Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD显示文摘 | Greenhill L Kollins S Abikoff H | | 0，，11： | 1 |
| 18 | Sleep problems in elementary school children: a community study 显示文摘 | Blader JC Koplewicz HS Abikoff H | 1997 | Arch Pediatr Adolese Med1997，151，： | 1 |
| 19 | Significance of childhood conduct problems to later development of conduct disorder among children with ADHD: a prospective follow-ups tudy显示文摘 | Mannuzza S Abikoff H | 2004 | J Abnorm Child Psychol2004，32，： | 1 |
| 20 | Medication treatment strantegies in the MTA study: Relevance to clinicians and researchers 显示文摘 | Greehill LL Abikoff HB Arnold LE | 1996 | J Am Acad Child Adolesc Psychiatry1996，34，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员