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23篇 您的检索式:作者名="Abecasis M"
    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Genome-wide association studies for complex traits: consensus, uncertainty and challenges 显示文摘MCCARTHY M I ABECASIS G R CARDON L R 2008Nat Rev Genet2008,9,:1
3Family-based association tests for genome wide association scans显示文摘Chen W M Abecasis G R 2007Am J Hum Genet2007,81,5:1
4Aortic coarctation repair in the adult显示文摘Cardoso G Abecasis M Anjos R 2014J Card Surg2014,29,4:1
5Preoperative evaluation of the entire hepatic vasculature in living liver donors with use of contrast enhanced MR angiography and true fast with steady state precession显示文摘Carr JC Nemcek AA Abecasis M 2003JVIR2003,14,4:1
6Long-term efficacy of torasemide compared with frusemide in cirrhotic patients with ascites显示文摘ABECASIS R GUEVARA M MIGUEZ C 2001Scand J Gastroenterol2001,36,3:1
7Positional cloning of a novel gene influencing asthma from chromosome 2q14 显示文摘Allen M Heinzmann A Noguchi E Abecasis G Nat Gcnet0,35,3:1
8Long term efficacy of torsemide compared with furosemide in cirrhotic patients with ascites显示文摘 Guevara M Miguez C 2001Scand J Gastroenterol2001,36,30:1
9Ge- nome-wide association studies for complex traits:consen- sus, uncertainty and challenges 显示文摘McCarthy M I Abecasis G R Cardon L R 2008Nat Rev Genet2008,9,5:1
10Daily variation in portal blood flow and the effect of propranolo administration in a randomized study of patients with cirrhosis 显示文摘Alvarez D de las Heras M Abecasis R 1997Hepatology1997,2,3:1
11Family-based association tests for genomewide association scans显示文摘CHEN W M ABECASIS G R 2007Am J Hum Genet2007,81,5:1
12Epicardial radiofrequency applications: in vitro and in vivo studies on human atrial myoeardium显示文摘Santiago T Melo J Gouveia R H Neves J Abecasis M Adrag:o P 2003Eur J Cardiothorac Surg2003,24,:1
13Toll-like receptor polymorphisms and age-related macu-lar degeneration显示文摘Edwards A O Chen D Fridley B L James K M Wu Y Abecasis G 2008Invest Ophthalmol Vis Sci2008,49,:1
14Depression in patients with myocardial infarction显示文摘Meneses R Almeida M C Abecasis J 2007Rev Port Cardiol2007,26,11:1
15Long term efficacy of torasecmid compared with frusemide in cirrhotic patients with ascites显示文摘ABECASIS R CUCVARA M MIGUEZC 2001Gastroenterol2001,36,3:1
16Splenichypofunction in cirrhosisis notassociated with increased risk forinfections 显示文摘LeviD M aurino E Abecasis R 1996EarJGastroenterol Hepatol1996,8,3:1
17A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants 显示文摘Scott L J Mohlke KL Bonnycastle LL Wilier CJ Li Y Duren WL Erdos MR Stringham HM Chines PS Jackson AU Prokunina-Olsson L Dingl CJ Swift AJ Narisu N Hu T Pruim R Xiao R Li XY Conneely KN Riebow NL Sprau AG Tong M White PP Hetrick KN Barnhart MW Bark CW Goldstein JL Watkins J Xiang F Saramies J Buchanan TA Watanabe RM Valle TT Kinnunen L Abecasis GR Pugh EW Doheny KF Bergman RN Tuomilehto J Collins FS Boehnke M 2007 2007Science2007,3161,5829:1
18Long-term efficacy of torsemide compared to frusemide in cirrhotic patients with ascites显示文摘Abecasis R Guevera M Miguez C 2001Scand J Gastroenterol2001,36,3:1
19Long- term efficacy of tosemide compared with furosemide in cirrhotic patients with ascites 显示文摘Abecasis R Guevara M Miguez C 2001Scand J Gastroenterol2001,36,3:1
20A map of human genome variation from population-scale sequencing显示文摘Durbin R M Abecasis G R Altshuler D L 2010Nature2010,467,:1
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