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| 1 | Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk显示文摘AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk predisposition.METHODS:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.RESULTS:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC risk.The haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical significance.CONCLUSION:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman. | Mansour S Al-Moundhri Manal Al-Khanbashi Mohammed Al-Kindi Maryam Al-Nabhani Ikram A Burney Abdulaziz Al-Farsi Bassim Al-Bahrani | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 2 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 3 | Mobilization and domain of bone marrow stromal cells in myocardial infarction显示文摘 | Bindu B Dominique S Abdulaziz A | 2003 | Eur J Cardio Surg2003，24，： | 1 |
| 4 | Comparison of delay analysis methodologies 显示文摘 | Abdulaziz A Bubshait Michael J Curnningham | 1998 | Journal of Construction Engineering and Management1998，124，4： | 1 |
| 5 | Effect of inclusion compl exation with cyclodextrins on photostability of nifedipine in solid state显示文摘 | Khalid A Abdulaziz A | 2002 | International Journal of Pharmaceutics2002，243，12： | 1 |
| 6 | Tea-ching communication skills显示文摘 | Abdulaziz A l Odhayani M D Savithiri R | | 0，，14： | 1 |
| 7 | Pediatric intraocular lens implantation: surgical results and complications in more than 300 patients 显示文摘 | Johan Z Paul BM Abdulaziz A | 1998 | Ophthalmology1998，105，： | 1 |
| 8 | Effect of levobupivacaine concentra tion on the efficacy of ultrasound guided interscalene brachial plexus block显示文摘 | Tariq A Abdulaziz A A | 2011 | SaudiJ Anaesth2011，5，2： | 1 |
| 9 | Therapeutic angiogenesis using autologous bone marrow stromal cells:improved blood flow in a chronic limb ischemia model显示文摘 | Abdulaziz AK Hilal A Jacques G | 2003 | Ann Thorac Surg2003，75，1： | 1 |
| 10 | Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots 显示文摘 | AbdulAziz A Hidetaka A Hideyoshi H | 2008 | J Phys Chem B2008，112，10： | 1 |
| 11 | Incentive/disincentive contracts and its effects on industrial projects 显示文摘 | Abdulaziz B A | 2003 | International Journal of Project Management2003，21，3： | 1 |
| 12 | The direct synthesis of pure zeolite-a using'virgin'Kaolin显示文摘 | Start M Holmes Abdulaziz A Alomair Abdul S Kovo | 2012 | RSC Advances2012，2，11： | 1 |
| 13 | Single-sensor 3D land seismic acquisition in Kuwait 显示文摘 | Ghassan R Abdulaziz A F | 2006 | Expanded Ab- stracts of 76^th Annual Internat SEG Mtg2006，6164，： | 1 |
| 14 | Maerobenthic com- munity structure in the northern Saudi waters of the Gulf, 14 years at2 ter the 1991 oil spill显示文摘 | Joyda T V Qurban M A Abdulaziz A S | 2012 | Marine Pollution Bulletin2012，64，： | 1 |
| 15 | Small bowel feeding and risk of pneumonia in adult critically ill patients: a systematic review and meta-analysis of randomized trials 显示文摘 | Waleed A Abdulaziz A | 2013 | Crit Care Med2013，17，4： | 1 |
| 16 | A clustering method for categorical data in tourism market segmentation research 显示文摘 | George A Abdulaziz E | 2001 | Journal of Travel Research2001，39，3： | 1 |
| 17 | Semiconductor quantum dots and metal nanoparticles syntheses optical properties and biological applications 显示文摘 | Vasudevanpillai B Tamitake I Abdulaziz A | 2008 | Anal Bioanal Chem2008，391，： | 1 |
| 18 | Studies on the reproductive, cytological and biochemical toxicity of Ginkgo Biloba in Swiss albino mice显示文摘 | Abdulaziz A Al-Yahya Abdulhakeem A | 2006 | Journal of Ethno-pharmacology2006，107，2： | 1 |
| 19 | Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic lime ischemia model 显示文摘 | Abdulaziz AK Hilal A Jacques G | 2003 | Ann Thorac Surg2003，75，1： | 1 |
| 20 | Same day discharge after structural heart disease interventions in the era of the coronavirus-19 pandemic and beyond显示文摘With recent advancements in imaging modalities and techniques and increased recognition of the long-term impact of several structural heart disease interventions,the number of procedures has significantly increased.With the increase in procedures,also comes an increase in cost.In view of this,efficient and cost-effective methods to facilitate and manage structural heart disease interventions are a necessity.Same-day discharge(SDD)after invasive cardiac procedures improves resource utilization and patient satisfaction.SDD in appropriately selected patients has become the standard of care for some invasive cardiac procedures such as percutaneous coronary interventions.This is not the case for the majority of structural heart procedures.With the coronavirus disease 2019 pandemic,safely reducing the duration of time spent within the hospital to prevent unnecessary exposure to pathogens has become a priority.In light of this,it is prudent to assess the feasibility of SDD in several structural heart procedures.In this review we highlight the feasibility of SDD in a carefully selected population,by reviewing and summarizing studies on SDD among patients undergoing left atrial appendage occlusion,patent foramen ovale/atrial septal defect closure,Mitra-clip,and trans-catheter aortic valve replacement procedures. | Abdulaziz A Asbeutah Muhammad Junaid Fatima Hassan Jesus Avila Vega Nephertiti Efeovbokhan Rami N Khouzam Uzoma N Ibebuogu | 2022 | World Journal of Cardiology2022，14，5： | 1 |
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