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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 3 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 4 | Self-efficacy Is Associated with Pain, Functioning, and Coping in Patients with Chronic Temporomandibular Disorder Pain显示文摘 | Brister H Turner J A Aaron L A | 2006 | J Orofac Pain2006，20，2： | 1 |
| 5 | Hypersonic boundary-layer trip develop ment for hyper-X显示文摘 | SCOTT A Berry AARON H Auslender ARTHUR D Dilley | 2001 | Journal of Spacecraft and Rock ets2001，38，6： | 1 |
| 6 | Evaluation of SiO2 and TiO2 coated BaFeO4 cathode ma- terials for zinc alkaline and lithium non-aqueous primary bat- teries显示文摘 | Kenneth A Walz Aaron Handrick Jeannine R Szczech | 2007 | J Power Sources2007，167，2： | 1 |
| 7 | Enantioselective chronic toxicity of fipronil to Ceriodaphnia dubia显示文摘 | AARON WILSON W KONWICK B J GARRISON A W | 2008 | Arch Environ Contam Toxicol2008，54，1： | 1 |
| 8 | Evidence-based practice and social work 显示文摘 | AARON C BRUCE A | 2004 | J Evidence Based Social Work2004，1，1： | 1 |
| 9 | Interleukin-10 regulation in normal subjects and patients with asthma显示文摘 | Borish L Aarons A Rumbyrt J | 1966 | J Allergy Clin Immunol1966，97，： | 1 |
| 10 | Cognitive behavioral therapy forschizophrenia:An empirical review显示文摘 | Rector Neil A Beck Aaron T | 2012 | Journal of Nervous&Men-tal Disease2012，200，10： | 1 |
| 11 | The effect of chronic infection with Aspergillus fumigatus on lung {unction and hospitalization in patients with cystic fibrosis 显示文摘 | Amin R Dupuis A Aaron SD | 2010 | Chest2010，137，1： | 1 |
| 12 | A-synuclein blocks er-golgi traffic and rabl rescues neuron loss in parkinson's models显示文摘 | Antony A Cooper Aaron D | 2006 | Science2006，313，5785： | 1 |
| 13 | Inva- sivem eningococcal disease in adolescents and young adults 显示文摘 | Lee HH arriso Margaret A Pass Aaron B Mendelsohn | 2001 | The Journal of the American Medical Association2001，286，6： | 1 |
| 14 | A simple and cost-effective method of DNA extraction from small formalin-fixed paraffinembedded tissue for molecular oncologic testing显示文摘 | Anthony N Snow Aaron A Stence Jonathan A Pruessner | 2014 | Carcinogenesis Clinical Pa- thology2014，30，14： | 1 |
| 15 | Interleukin-10 regulation in normal subjects and patients with asthma显示文摘 | Borish L Aarons A Rumbyrt J | 2003 | J Allergy Clin Immunol2003，97，6： | 1 |
| 16 | Distributed video coding显示文摘 | GIROD B AARON A M REBOLLO-MONEDERO D | 2005 | Proceeding of the IEEE2005，93，1： | 1 |
| 17 | Hypersonic boundary- layer trip development for Hyper-X 显示文摘 | Scott A B Aaron H A Authur D D | 2001 | Journal of Spacecraft and Rockets2001，38，6： | 1 |
| 18 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 19 | The influence of hook size, type, and location on hook retention and survival of angled bonefish 显示文摘 | Jeffrey A S Aaron D S Steven J C | 2012 | Fisheries Research2012，113，1： | 1 |
| 20 | C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) study显示文摘 | Nena A Diane C | 2002 | Am Heart J2002，144，： | 1 |
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