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| 1 | Emerging potential of exosomes for treatment of traumatic brain injury显示文摘Traumatic brain injury(TBI) is one of the major causes of death and disability worldwide.No effective treatment has been identified from clinical trials.Compelling evidence exists that treatment with mesenchymal stem cells(MSCs) exerts a substantial therapeutic effect after experimental brain injury.In addition to their soluble factors,therapeutic effects of MSCs may be attributed to their generation and release of exosomes.Exosomes are endosomal origin small-membrane nano-sized vesicles generated by almost all cell types.Exosomes play a pivotal role in intercellular communication.Intravenous delivery of MSC-derived exosomes improves functional recovery and promotes neuroplasticity in rats after TBI.Therapeutic effects of exosomes derive from the exosome content,especially micro RNAs(mi RNAs).mi RNAs are small non-coding regulatory RNAs and play an important role in posttranscriptional regulation of genes.Compared with their parent cells,exosomes are more stable and can cross the blood-brain barrier.They have reduced the safety risks inherent in administering viable cells such as the risk of occlusion in microvasculature or unregulated growth of transplanted cells.Developing a cell-free exosome-based therapy may open up a novel approach to enhancing multifaceted aspects of neuroplasticity and to amplifying neurological recovery,potentially for a variety of neural injuries and neurodegenerative diseases.This review discusses the most recent knowledge of exosome therapies for TBI,their associated challenges and opportunities. | Ye Xiong Asim Mahmood Michael Chopp | 2017 | Neural Regeneration Research2017，12，1： | 22 |
| 2 | Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities显示文摘 | Ye Xiong Asim Mahmood Michael Chopp | 2018 | Chinese Journal of Traumatology2018，21，3： | 19 |
| 3 | Predisposing factors, clinical assessment, management and outcomes of agitation in the trauma intensive care unit显示文摘BACKGROUND: Agitation occurs frequently among critically ill patients admitted to the intensive care unit(ICU). We aimed to evaluate the frequency, predisposing factors and outcomes of agitation in trauma ICU. METHODS: A retrospective analysis was conducted to include patients who were admitted to the trauma ICU between April 2014 and March 2015. Data included patient's demographics, initial vitals, associated injuries, Ramsey Sedation Scale, Glasgow Coma Scale, head injury lesions, use of sedatives and analgesics, head interventions, ventilator days, and ICU length of stay. Patients were divided into two groups based on the agitation status.RESULTS: A total of 102 intubated patients were enrolled; of which 46(45%) experienced agitation. Patients in the agitation group were 7 years younger, had significantly lower GCS and sustained higher frequency of head injuries(P<0.05). Patients who developed agitation were more likely to be prescribed propofol alone or in combination with midazolam and to have frequent ICP catheter insertion, longer ventilatory days and higher incidence of pneumonia(P<0.05). On multivariate analysis, use of propofol alone(OR=4.97; 95% CI=1.35–18.27), subarachnoid hemorrhage(OR=5.11; 95% CI=1.38–18.91) and ICP catheter insertion for severe head injury(OR=4.23; 95% CI=1.16–15.35) were independent predictors for agitation(P<0.01).CONCLUSION: Agitation is a frequent problem in trauma ICU and is mainly related to the type of sedation and poor outcomes in terms of prolonged mechanical ventilation and development of nosocomial pneumonia. Therefore, understanding the main predictors of agitation facilitates early risk-stratification and development of better therapeutic strategies in trauma patients. | Saeed Mahmood Omaima Mahmood Ayman El-Menyar Mohammad Asim Hassan Al-Thani | 2018 | World Journal of Emergency Medicine2018，9，2： | 5 |
| 4 | Remodeling dendritic spines for treatment of traumatic brain injury显示文摘Traumatic brain injury is an important global public health problem.Traumatic brain injury not only causes neural cell death,but also induces dendritic spine degeneration.Spared neurons from cell death in the injured brain may exhibit dendrite damage,dendritic spine degeneration,mature spine loss,synapse loss,and impairment of activity.Dendritic degeneration and synapse loss may significantly contribute to functional impairments and neurological disorders following traumatic brain injury.Normal function of the nervous system depends on maintenance of the functionally intact synaptic connections between the presynaptic and postsynaptic spines from neurons and their target cells.During synaptic plasticity,the numbers and shapes of dendritic spines undergo dynamic reorganization.Enlargement of spine heads and the formation and stabilization of new spines are associated with long-term potentiation,while spine shrinkage and retraction are associated with long-term depression.Consolidation of memory is associated with remodeling and growth of preexisting synapses and the formation of new synapses.To date,there is no effective treatment to prevent dendritic degeneration and synapse loss.This review outlines the current data related to treatments targeting dendritic spines that propose to enhance spine remodeling and improve functional recovery after traumatic brain injury.The mechanisms underlying proposed beneficial effects of therapy targeting dendritic spines remain elusive,possibly including blocking activation of Cofilin induced by beta amyloid,Ras activation,and inhibition of GSK-3 signaling pathway.Further understanding of the molecular and cellular mechanisms underlying synaptic degeneration/loss following traumatic brain injury will advance the understanding of the pathophysiology induced by traumatic brain injury and may lead to the development of novel treatments for traumatic brain injury. | Ye Xiong Asim Mahmood Michael Chopp | 2019 | Neural Regeneration Research2019，14，9： | 4 |
| 5 | Treatment of Traumatic Brain Injury in Adult Rats with Intravenous Administration of Human Bone Marrow Stromal Cells显示文摘 | Asim Mahmood Dunyue Lu Mei Lu Michael Chopp | 2003 | Neurosurgery2003，，3： | 1 |
| 6 | Progress in shivering control显示文摘 | M. Asim Mahmood Richard M. Zweifler | 2007 | Journal of the Neurological Sciences2007，，1： | 1 |
| 7 | Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response显示文摘 | Asad Mahmood Khan Muhammad Shahzad M. B. Raza Asim Muhammad Imran Arham Shabbir | 2014 | Pharmaceutical Biology2014，，： | 1 |
| 8 | Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome显示文摘 | Dunyue Lu Asim Mahmood Lei Wang Yi Li Mei Lu Michael Chopp | 2001 | Neuroreport2001，，3： | 1 |
| 9 | Treatment of Traumatic Brain Injury in Adult Rats with Intravenous Administration of Human Bone Marrow Stromal Cells显示文摘 | Asim Mahmood Dunyue Lu Mei Lu Michael Chopp | 2003 | Neurosurgery2003，，3： | 1 |
| 10 | Delayed Thrombosis after Traumatic Brain Injury in Rats显示文摘 | DUNYUE LU ASIM MAHMOOD ANTON GOUSSEV | 2004 | J Neurotrauma2004，21，： | 1 |
| 11 | Effects of posttraumatic carbamylated erythropoietin therapy on reduc- ing lesion volume and hippocampal cell loss,enhancing angiogenesis and neurogenesis,and improving functional outcome in rats following traumatic brain injury 显示文摘 | Ye Xiong Asim Mahmood Yanlu Zhang | 2011 | J Neu- rosurg2011，114，2： | 1 |
| 12 | Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury显示文摘 | Dunyue Lu Paul R Samberg Asim Mahmood | 2002 | Cell Transplantation2002，11，： | 1 |
| 13 | Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury显示文摘 | Paul R samberg Asim Mahmood | 2002 | Cell Transplantation2002，11，： | 1 |
| 14 | Neuroprotective and neurorestorative effects of thymosin β4 treatment following experimental traumatic brain injury显示文摘 | Ye Xiong Asim Mahmood Yuling Meng Yanlu Zhang Zheng Gang Zhang Daniel C. Morris Michael Chopp | 2012 | Annals of the New York Academy of Sciences2012，，1： | 1 |
| 15 | Marrow Stromal Cell Transplantation after Traumatic Brain Injury Promotes Cellular Proliferation within the Brain显示文摘 | Asim Mahmood Dunyue Lu Michael Chopp | 2004 | Neurosurgery2004，，5： | 1 |
| 16 | Targeting microthrombosis and neuroinflammation with vepoloxamer for therapeutic neuroprotection after traumatic brain injury显示文摘Traumatic brain injury(TBI):Despite improved supportive and rehabilitative care of TBI patients,TBI remains a leading cause of death and disability worldwide.To date,no effective pharmacological treatments are available for TBI.The mechanisms underlying brain damage and repair following TBI are complex and not completely understood.Coagulopathy after TBI is frequent and an independent prognostic factor for unfavorable outcome and prognosis(Stein and Smith,2004).It may be amenable to treatment,and effective management of coagulopathy may protect from secondary injury and poor outcomes.Although the | Ye Xiong Li Zhang Zheng Gang Zhang Asim Mahmood Michael Chopp | 2018 | Neural Regeneration Research2018，13，3： | 0 |
| 17 | Molecular evolution,virology and spatial distribution of HCV genotypes in Pakistan:A meta-analysis显示文摘Background:Hepatitis C,caused by the Hepatitis C Virus(HCV),is the second most common form of viral hepatitis.The geographical distribution of HCV genotypes can be quite complex,making it challenging to ascertain the most prevalent genotype in a specific area.Methods:To address this,a review was conducted to determine the prevalence of HCV genotypes across various provinces and as a whole in Pakistan.The scientific literature regarding the prevalence,distribution,genotyping,and epidemiology of HCV was gathered from published articles spanning the years 1996-2020.Results:Genotype 1 accounted for 5.1%of the patients,with its predominant subtype being 1a at 4.38%.The frequencies of its other subtypes,1b and 1c,were observed to be 1.0%and 0.31%respectively.Genotype 2 had a frequency of 2.66%,with the most widely distributed subtype being 2a at 2.11%of the patients.Its other subtypes,2b and 2c,had frequencies of 0.17%and 0.36%respectively.The most prevalent genotype among all isolates was 3(65.35%),with the most frequent subtype being 3a(55.15%),followed by 3b(7.18%).The prevalence of genotypes 4,5,and 6 were scarce in Pakistan,with frequencies of 0.97%,0.08%,and 0.32%respectively.The prevalence of untypeable and mixed genotypes was 21.34%and 3.53%respectively.Estimating genotypes proves to be a productive method in assisting with the duration and selection of antiviral treatment.Different HCV genotypes can exhibit variations in their response to specific antiviral treatments.Different genotypes may have distinct natural histories,including variations in disease progression and severity.Some genotypes may lead to more rapid liver damage,while others progress more slowly.Conclusions:This information can guide screening and testing strategies,helping to identify individuals at higher risk of developing severe complications.Studying the distribution of HCV genotypes in a population can provide valuable insights into the transmission dynamics of the virus. | Arslan Habib Nadiya Habib Khalid Mahmood Anjum Riffat Iqbal Zeeshan Ashraf Muhammad Usman Taj Muhammad Asim Kanwal Javid Faezeh Idoon Saeid Dashti Cassio Rocha Medeiros Ana Pavla Almeida Diniz Gurgel Henrique Douglas Melo Coutinho | 2023 | Infectious Medicine2023，2，4： | 0 |
| 18 | Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration显示文摘Traumatic brain injury is a serious and complex neurological condition that affects millions of people worldwide.Despite significant advancements in the field of medicine,effective treatments for traumatic brain injury remain limited.Recently,extracellular vesicles released from mesenchymal stem/stromal cells have emerged as a promising novel therapy for traumatic brain injury.Extracellular vesicles are small membrane-bound vesicles that are naturally released by cells,including those in the brain,and can be engineered to contain therapeutic cargo,such as anti-inflammatory molecules,growth factors,and microRNAs.When administered intravenously,extra cellular vesicles can cross the blood-brain barrier and deliver their cargos to the site of injury,where they can be taken up by recipient cells and modulate the inflammatory response,promote neuroregeneration,and improve functional outcomes.In preclinical studies,extracellular vesicle-based therapies have shown promising results in promoting recove ry after traumatic brain injury,including reducing neuronal damage,improving cognitive function,and enhancing motor recovery.While further research is needed to establish the safety and efficacy of extra cellular vesicle-based therapies in humans,extra cellular vesicles represent a promising novel approach for the treatment of traumatic brain injury.In this review,we summarize mesenchymal ste m/stromal cell-de rived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration and brainderived extracellular vesicles as potential biofluid biomarkers in small and large animal models of traumatic brain injury. | Ye Xiong Asim Mahmood Michael Chopp | 2024 | Neural Regeneration Research2024，19，1： | 0 |
| 19 | A Comparative Study of Ditransitive Verb Complementation Patterns in Pakistani and British Englishes显示文摘 | Muhammad Asim Mahmood Saeed UI Hassan Rashid Mahmood Noureen Arif | 2012 | US-China Foreign Language2012，10，5： | 0 |
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