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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice 显示文摘 | Wang J Asensio V C Campbell I L | 2002 | Curr Top Microbiol Immunol2002，265，： | 1 |
| 3 | The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis显示文摘 | Gonzalo Asensio J Maia C Ferrer NL | 2006 | Journal of Biological Chemistry:2006，281，3： | 1 |
| 4 | Effect of heat treatment on the proteolytic activity of mesophilic bacteria isolated from goat's milk cheese显示文摘 | Asensio C Gomez R Pelaez C | 1995 | Applied Microbiology1995，21，1： | 1 |
| 5 | Cocaine addiction: diffusion tensor imaging study of the inferior frontal and anterior cingulate white matter显示文摘 | Romero M] Asensio Sv Palau C Sanchez A Romero FJ | 2010 | Psychiatry Res2010，181，： | 1 |
| 6 | Molecular characterization of a novel type II keratin gene (sseKer3) in the Senegalese sole (Solea senegalensis) :differential expression of keratin genes by salinity 显示文摘 | Infante C Ponce M Asensio E | 2011 | Comparative Biochemistry and Physiology Part B2011，160，1： | 1 |
| 7 | Use of heat-shocked mesophilic lactic acid bacteria in low-fat goat's milk cheesemaking 显示文摘 | Asensio C Parra L Pelaez C | 1996 | Journal of Agricultural and Food Chemistry1996，44，9： | 1 |
| 8 | Selection of housekeeping genes for gene expression studies in larvae from flatfish using real-time PCR显示文摘 | Infante C Matsuoka M P Asensio E | 2008 | BMC Mol Biol2008，9，： | 1 |
| 9 | Behaviour of organic pollutants in paper and board samples intended to be in contact with food显示文摘 | NERIN C ASENSIO E | | 0，，02： | 1 |
| 10 | Crystalline polymorphism and molecular structure of sodium pravastatin 显示文摘 | Martin-Islan A P Cruzado M C Asensio R | 2006 | J Phys Chem B2006，110，51： | 1 |
| 11 | Behaviour of organic pollutants in paper and board samples intended to be in contact with food 显示文摘 | Nerin C Asensio E | 2004 | Analytica Chimica Acta2004，508，： | 1 |
| 12 | Selection of housekeep ing genes for gene expression studies in larvae from flatfish using real time PCR显示文摘 | Infante C Matsuoka M P Asensio E | 2008 | BMC Molecular Biology2008，9，1： | 1 |
| 13 | Changes in glycemia by leptin administration or high-fat feeding in rodent mod- els of obesity/type 2 diabetes suggest a link between resistin ex- pression and control of glucose homeostasis 显示文摘 | Asensio C Cettour-Rose P Theander-Carrillo C | 2004 | Endocrinology2004，145，5： | 1 |
| 14 | Changes of glycemia by leptin administration or high fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis 显示文摘 | Asensio C Cettour-Rose P Theander-Carrillo C | 2004 | Endocrinology2004，145，5： | 1 |
| 15 | Analytical characterization of polymers used in conservation and restoration by ATR-TIR spectroscopy 显示文摘 | Asensio R C Moya M S Roja J M | 2009 | Analytical andBioanalytiealChemistry2009，11，7： | 1 |
| 16 | Effect of Heat Treatment on The Proteolytic Activity of Mesophilic Bacteria Isolated from Goats Milk Cheese显示文摘 | ASENSIO C GOMEZ R PELAEZ C | 1995 | Letters in Applied Microbiology1995，21，： | 1 |
| 17 | Can serum hyaluronic acidreplace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients 显示文摘 | Resino S Bellon JM Asensio C | 2010 | BMC Infect Dig2010，10，： | 1 |
| 18 | Behaviour of organic pollutants in paper and board samples intended to be in contact with food显示文摘 | NERIN C ASENSIO E | | 0，，2： | 1 |
| 19 | Bifidobacterium breve and streptococcus thermophilus secretion products enhance T helper 1 immune response and intestinal barrier in mice显示文摘 | Menard S Laharie D Asensio C | 2005 | Exp Biol Med2005，230，10： | 1 |
| 20 | Mineralocorticoid receptor antagonists modulate galectin - 3 and interleukin- 33/ST2 signaling in left ventricular systolic dysfunction after acute myocardial infarction 显示文摘 | LAX A SANCHEZ - MAS J ASENSIO - LOPEZ M C | 2015 | JACC Heart Fail2015，3，1： | 1 |
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