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| 1 | Synthesis, characterization and biological applications of novel Schiff bases of 2-(trifluoromethoxy) aniline显示文摘A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods. Crystal structure of one new compound was also reported. The pharmacological properties, including antibacterial(14 bacterial species), antifungal(7 strains), antimalarial, anti-trypanosomal and anti-HIV activities of the compounds, were investigated. Cytotoxicity of the tested compounds was evaluated against human cervix adernocarcinoma cells(He La). Bacterial minimum inhibitory concentration(MIC) results by broth microdilution method showed that Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella oxytoc and Klebsiella pneumonia were more sensitive in the presence of tested compounds with an MIC value of 15.6 μg/m L. All the tested compounds showed good to moderate activity against fungi. The sensitivity of Aspergillus fumigatus was higher than other strains with a minimum cell death concentration(MFC) of 15.6 μg/m L. Compound 1 showed greater antimalarial and anti-trypanosomal properties with very low to no cytotoxic effects against He La cells as compared with compound 5, while other compounds exhibited poor activity. Compounds 1–5 demonstrated good activity against HIV type-1. These Schiff base compounds could be used as good antimicrobial agents. | Thierry Youmbi Fonkui Monisola Itohan Ikhile Freddy Munyololo Muganza Marthe Carine Djuidje Fotsing Charmaine Arderne Xavier Siwe-Noundou Rui Werner Macedo Krause Derek Tantoh Ndinteh Patrick Berka Njobeh | 2018 | Journal of Chinese Pharmaceutical Sciences2018，27，5： | 2 |
| 2 | Associations between the built environment, total, recreational, and transit-related physical activity 显示文摘 | De Sa E Ardern CI | 2014 | BMC Public Health2014，14，： | 1 |
| 3 | Failure of a monotherapy strategy for difficult chronic prostatitis/ chronic pelvic pain syndromes显示文摘 | Nickel JC Downey J Ardern D | 2004 | J Urol2004，172，2： | 1 |
| 4 | Acute chemotherapyrelated toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom显示文摘 | Shanley S McReynolds K Ardern -Jones A | 2006 | Clin Cancer Res2006，12，： | 1 |
| 5 | Failure of a monotherapy strategy for difficult chronic prostatitis/chronic pelvic pain syndrome显示文摘 | Nickel J C Downey J Ardern D | | 0，，02： | 1 |
| 6 | The use of digital' virtual slides' in the quality assessment of haematological morphology: results of a pilot exercise involving UK NEQAS ( H ) participants 显示文摘 | Burthem J Brereton M Ardern J | 2005 | Br J Haematol2005，130，2： | 1 |
| 7 | Development of health-related waist circumference thresholds within BMI categories显示文摘 | Ardern C I Janssen I Ross R | 2004 | Obes Res2004，12，7： | 1 |
| 8 | Metabolic syndrome and its asso- ciation with morbidity and mortality 显示文摘 | ARDERN CI JANSSEN I | 2007 | Appl Physiol Nutr Metab2007，32，： | 1 |
| 9 | Overweight and obesity mortality trends in Canada,1985-2000显示文摘 | KATZMARZYK P T ARDERN C I | 2004 | Can J Public Health2004，95，1： | 1 |
| 10 | Degree and correlates of cardiac knowledge and awareness among cardiac inpatients显示文摘 | Kayaniyil S Ardern C | 2009 | Patient Educ Couns2009，75，1： | 1 |
| 11 | Degree and correlates of cardiac knowledge and awareness among cardiac inpatients显示文摘 | Kayaniyil S Ardern C | 2009 | Patient Educ Couns2009，75，1： | 1 |
| 12 | Experiments of the oxidation of sewage without the aid of filters显示文摘 | Ardern E Lockett W T | 1914 | J Soc Chem Ind1914，33，： | 1 |
| 13 | Overweight and obesity mortality trends in Canada,1985-2000显示文摘 | Katznarzyk PT Ardern CI | | 0，，01： | 1 |
| 14 | FAILURE OF A MONOTHERAPY STRATEGY FOR DIFFICULT CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME显示文摘 | J. CURTIS NICKEL JOE DOWNEY DALE ARDERN JANET CLARK KYLE NICKEL | 2004 | The Journal of Urology2004，，2： | 1 |
| 15 | Overweight and obesity mortality trends in Canada,1985-2000显示文摘 | Katzmarzyk PT Ardern CI | 2004 | Can J Public Health2004，95，1： | 1 |
| 16 | Src-dependent phosphorylation of Scarl promotes its as- sociation with the Arp2/3 complex 显示文摘 | ARDERN H SANDILANDS E MACHESKY LM | 2006 | Cell Motil Cy- toskeleton2006，63，1： | 1 |
| 17 | A population--based study of potential brain injuries requiring emergency care 显示文摘 | Pickett W Ardern C Brison RJ | 2001 | CMAJ2001，，： | 1 |
| 18 | Degree and corre- lates of cardiac knowledge and awareness among cardiac Inpa- lients显示文摘 | Kayaniyit S Ardern CI Winstanley J | 2009 | Patient Educ Couns2009，75，1： | 1 |
| 19 | Failure of a monotherapy strategy for difficult chronic prostatis / chronic pelvic painsyn- drome显示文摘 | Nickel JC Doweny J Ardern D etal | 2004 | J Urol2004，172，2： | 1 |
| 20 | Are metabolically normal but obese individuals at lower risk for all-cause mortality? 显示文摘 | KUK J L ARDERN C I | 2009 | Diabetes Care2009，32，12： | 1 |
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