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| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 3 | Dynamic Power Allocation for Broadband Multi-Beam Satellite Communication Networks 显示文摘 | Apostolos Destounis Athanasios D Panagopoulos | 2011 | IEEE Communications Letters (S1089-7798)2011，15，4： | 1 |
| 4 | Chaos Based Communications at High Bit Rates Using Commercial Fibre-optic Links显示文摘 | Apostolos A Syvridis D Larger L | 2005 | Nature2005，438，7066： | 1 |
| 5 | Primary malignant melanoma of the lung:a case report显示文摘 | APOSTOLOS D CHARALAMBOS Z EVANGELIA K | 2003 | World J Surg Oncol2003，1，1： | 1 |
| 6 | Transdermal drug delivery with a pressure wave 显示文摘 | APOSTOLOS G D NIKIFOROS K | 2004 | Adv Drug Deliv Rev2004，56，5： | 1 |
| 7 | Texture evaluation of block-type processed cheese as a function of chemical composition and in relation to its apparent viscosity显示文摘 | Georgia D Apostolos S T | 2007 | Journal of Food Engineering2007，79，： | 1 |
| 8 | Adsorp- tion of Organophosphates Into Microporous and Meso- porous Nax Zeolites and Subsequent Chemistry显示文摘 | Meng Q G David C D Apostolos K R | 2011 | En- vironmental Science Technoloy2011，45，7： | 1 |
| 9 | Effect of temperature and chemical composition on processed cheese apparent viscosity显示文摘 | Georgia D Apostolos S T | 2004 | Journal of Food Engineering2004，64，： | 1 |
| 10 | Syvridis Performance Characterization of High-Bit-Rate Optical Chaotic Communication Systems in a Back-to-Back Configuration显示文摘 | Dimitris Kanakidis Apostolos Argyris and D | 2003 | IEEE Journal of Lightwave Technology2003，21，3： | 1 |
| 11 | Quantitative analysis of energy metabolic pathways in MCF-7 breast cancer cells by se- lected reaction monitoring assay显示文摘 | Andrei D Maria P Apostolos D | 2012 | Mol Cell Proteomics2012，11，8： | 1 |
| 12 | Primary Malig- nant Melanoma of the Lung: A Case Report显示文摘 | Apostolos D Charalambos Z Evangelia K | 2003 | World Journal of Surgical Oncology2003，，23： | 1 |
| 13 | Pri mary Malig-nant Melanoma of the lung:A case report显示文摘 | Apostolos D Charalambos Z Evangelia K | 2003 | J Surg Oncol2003，1，1： | 1 |
| 14 | Cytoplasmic molecular delivery with shock waves:importance of impulse显示文摘 | TETSUYA K MICHAEL R H APOSTOLOS G D | 2000 | Biophysical Journal2000，79，： | 1 |
| 15 | Primary Malignant Melanoma of the lung:A case report显示文摘 | Apostolos D Charalambos Z Evangelia K | 2003 | World J Surg Oncol2003，1，1： | 1 |
| 16 | Outcome f patiaents with diffuse axanal injury: the significance and posnostic value of MRI in the acute phase 显示文摘 | KASTAS P APOSTOLOS H KARAUTANAS M D | 2000 | J Trauma2000，49，6： | 1 |
| 17 | Effect of chemical composi- tion on the linear viscoelastic properties of spreadable type processed cheese显示文摘 | Georgia D Apostolos S T | 2008 | Journal of Food Engineering2008，84，3： | 1 |
| 18 | Biomechanical properties of the scapholunate ligament and the importance of its portions in the capitate intrusion injury显示文摘 | Fotios V Emmanuel P Apostolos D | | 0，，： | 1 |
| 19 | Development of an FPGA - Based SPWM generator for high switching frequency DC/ AC inverters 显示文摘 | MATINA L EFTICHIOS K APOSTOLOS D | 2014 | IEEE transactions on Power Electronics2014，，29： | 1 |
| 20 | Primary malignant melanoma of the lung:a case of report显示文摘 | Apostolos D Charalambo S Evangelia K | | 0，，01： | 1 |
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