| 1 | Research on Characters of Leaf Epidermal Cells' Quantities of Solanaceous Vegetable Crops显示文摘Tomatoes,peppers and eggplants' seedings were used as experiment materials to study the leaf development mechanism of solanaceous vegetable crops by using blot observation method.Results showed that an increasing trend was presented at the density of cells and stomata in upper and lower epidermis,but a declined trend was presented at the cells' diameters and the size of stomata with the joint position rising.At the same joint position,no matter in adaxial side or abaxial side,there were some differences among cells diameters,size of stomata,density of cells and stomata. | YU Longfeng AN Fuquan GAO Jinhe LI Fuheng | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，3： | 0 |
| 2 | A subpopulation of CD146^(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome显示文摘As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneous nature restricts their application in tumor immunotherapy. In this study, we identified a subpopulation of CD146+ TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively controlled by STAT3 signaling. Reducing this population of TAMs promoted tumor development by facilitating myeloid-derived suppressor cell recruitment via activation of JNK signaling. Interestingly, CD146 was involved in the NLRP3 inflammasome-mediated activation of macrophages in the tumor microenvironment, partially by inhibiting transmembrane protein 176B (TMEM176B), an immunoregulatory cation channel. Treatment with a TMEM176B inhibitor enhanced the antitumor activity of CD146+ TAMs. These data reveal a crucial antitumor role of CD146+ TAMs and highlight the promising immunotherapeutic approach of inhibiting CD146 and TMEM176B. | Lin Jing Yunhe An Tanxi Cai Jianquan Xiang Baoming Li Jiang Guo Xinran Ma Ling Wei Yanjie Tian Xiaoyan Cheng Xuehui Chen Zheng Liu Jing Feng Fuquan Yang Xiyun Yan Hongxia Duan | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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