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| 1 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 2 | Metal concentrations in surface water and sediments from Pardo River,Brazil:human health risks显示文摘 | Alves RI Sampaio CF Nadal M | 2014 | Environ Res2014，133，： | 1 |
| 3 | 查看详情显示文摘 | Alves CF | | 0，，： | 1 |
| 4 | IL-12 enhances protectiveimmunity in mice engendered by immunization with recombinant14kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway 显示文摘 | Fonseca CT Brito CF Alves JB | 2004 | Vaccine2004，22，34： | 1 |
| 5 | IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 ku Schistosoma mansoni fatty acid2binding protein through an IFN-gamma and TNF-alpha dependent pathway显示文摘 | Fonseca CT Brito CF Alves JB | 2004 | Vaccine2004，22，34： | 1 |
| 6 | Expression of IFN-γ,TNF-α,IL-10 and TGF-βin lymph nodes associates with parasite load and clinical form of disease in dogs naturally infected with Leishmania chagasi显示文摘 | Alves CF de Amorim IF Moura EP | 2009 | Vet Immunol Immunopathol2009，128，4： | 1 |
| 7 | IL-12 enhances protec tive immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway 显示文摘 | Brito CF Alves JB | 2004 | Vaccine2004，22，34： | 1 |
| 8 | IL-12 enhancesprotective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway显示文摘 | FONSECA CT BRITO CF ALVES JB | 2004 | Vaccine2004，22，34： | 1 |
| 9 | Ilie effects of proresolution ofellagic acid in an experimental model of allergic airway inflammation显示文摘 | Alves CF Angeli GN Favarin DC’ | 2013 | Mediators Inflamm2013，2013，86： | 1 |
| 10 | Relevance of HLA-G, HLA-E and IL-10 expression in lip carcinogenesis显示文摘 | Gon?alves AS Oliveira JP Oliveira CF | 2016 | Hum Immunol2016，77，9： | 1 |
| 11 | Worldwide genetic variability of the Duffy binding protein : insights into Plas- modium vivax vaccine development 显示文摘 | Nobrega de Sousa T Carvalho LH Alves de Brito CF | 2011 | PLoS One2011，6，22： | 1 |
| 12 | IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway显示文摘 | Fonseca CT Brito CF Alves JB | 2004 | Vaccine2004，22，34： | 1 |
| 13 | The effects of proresolution of ellagic acid in an experimental model of allergic airway inflammation 显示文摘 | ALVES CF ANGELI GN FACCIOLI LH | 2013 | Mediators lnflamm2013，2013，86： | 1 |
| 14 | Quercetin : a lavonoid with the potential to treat asthma 显示文摘 | FORTUNATO LR ALVES CF TEIXEIRA MM | 2012 | Braz J Pharm Sei2012，48，4： | 1 |
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