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| 1 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 2 | Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls显示文摘 | Mustafa Erhan Altun?z Ebubekir ?enate? Atakan Ye?il Turan ?alhan Ay?e Oya Kurda? ?vün? | 2012 | Digestive Diseases and Sciences2012，，4： | 3 |
| 3 | Food impaction in older age:Think about an eosinophilic esophagitis显示文摘Eosinophilic esophagitis is an inflammatory condition of esophagus.It is generally seen in childhood and young population.Men are more commonly affected than women.However,it is not common in an advanced age.Eosinophilic esophagitis decreases the ability of the esophagus to stretch and accommodation against foods.Therefore,the major symptom in adults with eosinophilic esophagitis is difficulty in swallowing solid food(dysphagia).Specifically,the food gets stuck in the esophagus after it is swallowed.Less common symptoms include heartburn and chest pain.Because of this,it may be incorrectly diagnosed as a gastroesophageal reflux disease.Here,we reported a case presented with food impaction at advanced age.As a conclusion,eosinophilic esophagitis is a rare entity that must be remembered in advance aged patients presenting with food impaction. | Umit Akyüz Filiz Akyüz Kamil zdil Hasan Altun Ahmet Faruk Agan Aysegül Agan | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，2： | 2 |
| 4 | Stable isotope analysis reveals relative influences of seasonal hydrologic variation and impoundment on assimilation of primary production sources by fish in the upper Yeslhrmask River, Turke 显示文摘 | Kaymak N Winemiller K O Akin S Altuner Z Pola F Dal T | 2015 | Hydrobiologia2015，753，1： | 1 |
| 5 | Effect of cytotoxie agents and retinoic acid on Mye-N protein expression in neuroblastoma 显示文摘 | Aktas S Altun Z Erbayraktar Z | 2010 | Appl Immunohistochem Mol Morphol2010，18，1： | 1 |
| 6 | New trends in sample preparation: on-line microextraction in packed syringe (MEPS) for LC and GC applications Part III: determination and validation of local anaesthetics in human plasma samples using a cation-exchange sorbent and MEPS-LC-MS-MS 显示文摘 | ALTUN Z ABDEL-REHIM M BLOMBERG L G | 2004 | J Chromatogr B2004，，： | 1 |
| 7 | An alternative treatment in hy- pertriglyceridemia-induced acute pancreatitis in pregnancy: Plas- mapheresis显示文摘 | Altun D Eren G Cukurova Z | 2012 | J Anaesthesiol Clin Pharmacol2012，28，2： | 1 |
| 8 | Protective effect of acetyl-L- carnitine against cisplatin ototoxicity: role of apoptosis-related genes and pro-inflammatory cytokines 显示文摘 | Altun Z Olgun Y Ercetin P | 2014 | Cell Prolif2014，47，1： | 1 |
| 9 | An alternative treatment in hyper-triglyceridemia -induced acute pancreatitis in pregnancy : Plasmaph-eresis显示文摘 | Altun D Eren G Cukurova Z | 2012 | J Anaesthesiol Clin Pharmacol2012，28，2： | 1 |
| 10 | Promoting effects of sanguina- rine on apoptotic gene expression in human neuroblastoma cells显示文摘 | Cecen E Altun Z Ercetin P | 2014 | Asian Pac J Cancer Prey2014，15，2： | 1 |
| 11 | Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells显示文摘 | Wagner J A | 1996 | J Neurosci Res1996，44，4： | 1 |
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