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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 3 | A Revised Weighted Sum Decision Model for Robot Selection显示文摘 | Goh C H Alex T Y C Cheng Chun-Hung | 1996 | Computers and Industrial Engineering1996，30，2： | 1 |
| 4 | The future renewable electric energy delivery and management system: the energy internet 显示文摘 | Alex H Mariesa L C Gerald T H | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 5 | Parameter estimation of a real single tone from short data records 显示文摘 | FUNGA H W ALEX C KOTB K H l | 2004 | Signal Processing2004，84，： | 1 |
| 6 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 7 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 8 | Parameter estimation of a real signal tone from short data records显示文摘 | FUNGA H W ALEX C KOTB K H | 2004 | Signal Processing2004，84，： | 1 |
| 9 | Prediction of equivalent steady-state chloride diffhsion coefficients显示文摘 | Pratanu C~ Alex H Paul J T | 2011 | ACI Materials Journal2011，108，1： | 1 |
| 10 | Parameter estimation of a real single tone from short data records显示文摘 | H W Fung Alex C Kot K H Li Kah Chan Teh | 2004 | IEEE Transactions on Signal Processing2004，84，3： | 1 |
| 11 | Doa estimation of speech source with microphone arrays显示文摘 | Ming J Alex C K Meng H E | 1998 | Circuits and Systems1998，98，： | 1 |
| 12 | Barization of low-quality barcode images captured by mobile phones using local window of adaptive location and size显示文摘 | Yang H Alex C Jiang X | 2011 | IEEE Trans on Image Processing2011，21，1： | 1 |
| 13 | Effect of substrate angle on properties of ITO films deposited by cathodic arc ion plating with In-Sn alloy target显示文摘 | ALEX J C W KAI L C MING H Y | 2005 | Surface and Coatings Technology2005，198，： | 1 |
| 14 | Parameter estimation of a real single tone from short data records 显示文摘 | Funga H W Alex C Kotb K H Li | 2004 | Signal Processing2004，84，3： | 1 |
| 15 | The future renewable electric energy delivery and management system: the energy interact显示文摘 | Alex H Mariesa L C Gerald T H | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 16 | Scheduling uniform parallel machines subject to a secondary resource to minimize the numbor of tardy jobs显示文摘 | Alex J Ruiz T Franeisco J L Johnny C H | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 17 | Solar photocatalytic thin film cascade reactor for treatment of benzoic acid containing wastewater显示文摘 | Alex H C Chan Chak K Chan John P Barford | 2003 | Water Research2003，37，： | 1 |
| 18 | Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes 显示文摘 | RAYMOND H S WINNIE W S ALEX H C | 1992 | Infection and Immunity1992，60，7： | 1 |
| 19 | Design Aesthetics Leading to M-Loyalty in Mobile Commerce显示文摘 | Dianne C Milena H Alex I | 2006 | Information and Management2006，43，8： | 1 |
| 20 | A Revisedweighted sum decision model for robot selection显示文摘 | GOH C H ALEX TUNG Y C CHENG C H | 1996 | Computers & Industrial Engineering1996，30，2： | 1 |
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