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12篇 您的检索式:作者名="ALEC C"
    题名 作者 年代 出处 被引量
1The impact of hypothermia on trauma care at the 31st combat support hospital显示文摘Zachary A Daniel C Alec B 2006Am J Surg2006,191,5610:1
2Optimization of the bistability property for flexible display by an integrated approach using Taguchi methods, neural networks and genetic algorithms显示文摘Su C T Lin C M Alec Chang C 2012Microelectronics Reliability2012,52,7:1
3Neural networks and Fourier descriptors for part positioning using bar code fea- tures in material handling systems显示文摘Chang C Alec Lo C C Hsieh K H 1997Computers & Indus- trial Engineering1997,32,2:1
4Excess of depressive symptoms and life events among diabetics显示文摘Monique R Bronwyn C Alec R 1994Comprehensive Psychiatry1994,35,2:1
5Fuzzy neural networks for intelligent design retrieval using associative manufacturing features 显示文摘Tasi C Y Alec C C 2003Journal of Intelligent Manufacturing2003,14,1:1
6NEXAFS spectroscopy of CVD diamond films exposed to fusion relevant hydrogen plasma 显示文摘Mathew C G Alec D Cameron M S 2013Diamond Related Mater2013,34,:1
7Dissection of a nuclear localization signal显示文摘MARY R H ANITA H C ALEC E H 2001Biol Chem2001,276,2:1
8Using AHP and TOPSIS approaches in customer-driven product design process显示文摘LIN MINGCHYUAN WANG CHENCHENG CHEN MING SHI CHANG C ALEC 2008Computers in Industry2008,59,1:1
9Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies 显示文摘Jayne M Stommel Alec C Kimmelman Haoqiang Ying 2007Science2007,318,5848:1
10Efficiency, flexibil- ity, or both? evidence linking strategy to performance in small firms 显示文摘EBBEN JAY J JOHNSON ALEC C 2005Strategic Management Journal2005,26,:1
11Neural networks and Fourier descriptors for part positioning using bar code features in material handlingsystems显示文摘Alec C C Lo Chih Chung Hsieh Kuang Han 1997Computers & Industrial Engineering1997,32,2:1
12白介素-33至白介素-13信号级联调节小鼠胃组织上皮化生显示文摘目的选择性活化巨噬细胞 (Alternativelyactivated macrophages, M2)与胃部解痉多肽表达性化生(spasmolytic polypeptide-expressingmetaplasia, SPEM) 过程相关。然而,诱导SPEM的确切机制及关键介质尚不明确。研究设计为确定这一过程中的关键基因,分离胃部SPEM小鼠(DMP-777处理)及高级胃部SPEM小鼠(L635处理)胃体的巨噬细胞进行RNA测序。评估白介素.33、白介素-33受体(ST2)及白介素-13基因敲除小鼠,经L635处理急性壁细胞缺失后对上皮细胞化生过程的影响。结果胃部上皮化生相关性巨噬细胞中可鉴定出M2极化亚群。高级胃部SPEM小鼠巨噬细胞中自介素-33的表达显著上调。L635可在野生型小鼠胃组织中诱导上皮化生,但在白介素-33及白介素.33受体敲除鼠中未观察到这一现象。尽管在诱导上皮化生过程中不需白介素.5及白介素-9,白介素-13基因敲除小鼠无法在L635诱导下发生上皮化生。对白介素-33受体基因敲除小鼠应用白介素-13,可重新诱导急性壁细胞缺失后的上皮化生。结论壁细胞缺失后上皮化生及巨噬细胞极化过程通过白介素.33及白介素-13的细胞信号网络协调进行,将损伤应答过程中固有黏膜机制及M2浸润联系起来。Christine P Petersen Anne R Meyer Carlo De Salvo Eunyoung Choi Cameron Schlegel Alec Petersen Amy C Engevik Nripesh Prasad Shawn E Levy R Stokes Peebles Theresa T Pizarro James R Goldenring 李佳宁(译) 吴东(校) 2018英国医学杂志中文版2018,21,7:0
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