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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Assessing patterns of geographic dispersal of Gelidium sesquipedale(Rhodophyta)through RAPD differentiation of populations显示文摘 | Alberto F Santos R Leitao J M | 1999 | Marine Ecology Progress Series1999，191，： | 1 |
| 3 | A new methodology for the coordinated design of robust decentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 4 | A newmethodology for the coordinated design of robustdecentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEETransactions on Power Systems2004，19，1： | 1 |
| 5 | In vitro and in vivo behavior of Ca and P enriched anodized titanium 显示文摘 | MILENA F ALBERTO C GIANNI R | 1999 | 20 :1587-15941999，20，： | 1 |
| 6 | In vitro and in vivo behaviour of Ca- and P-enriched anodized titanium 显示文摘 | Alberto C Gianni R | 1999 | Biomaterials1999，，20： | 1 |
| 7 | A New Methodology for the Coordinated Design of Robust Decentralized Power System Damping Controllers 显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | Power Systemsd IEEE Transactions on2004，19，1： | 1 |
| 8 | A small fraction of dermatan sulfate with significantly increased anticoagulant activity was selected by interaction with the first complement protein显示文摘 | CALABRESE G C ALBERTO M F TUBIO R | 2004 | Thromb Res2004，113，： | 1 |
| 9 | A new methodology for the coordinated design of robust decentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 10 | Is asexual reproduction more important at geographical limits? A genetic study of the seagrass Zostera marina in the Ria Formosa, Portugal 显示文摘 | BELIJNGHAM M R REUSCH T B H ALBERTO F | 2003 | Mar Ecol-Prog Ser2003，265，： | 1 |
| 11 | Pyrosequencing enumerates and contrasts soil microbial diversity 显示文摘 | RoESCH LUIZ F W FULTHORPE ROBERTA R RI-VA Alberto | 2007 | The ISME Journal2007，1，4： | 1 |
| 12 | Evi- dence of the physiotherapeutic interventions used currently af- ter exercise-induced muscle damage: Systematic review and me- ta-analysis显示文摘 | TORRES R RIBEIRO F ALBERTO DUARTE J | 2012 | Phys Ther Sport2012，13，2： | 1 |
| 13 | Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials显示文摘 | Peter M Rothwell Jacqueline F Price F Gerald R Fowkes Alberto Zanchetti Maria Carla Roncaglioni Gianni Tognoni Robert Lee Jill FF Belch Michelle Wilson Ziyah Mehta Tom W Meade | 2012 | The Lancet . 2012 (9826)2012，，： | 1 |
| 14 | Apocrine Secretion of Amylase and Exocytosis of Trypsin along the Midgut of Tenebrio molitor Larvae显示文摘 | PLINIO T C ALBERTO F R WALTER R T | 2001 | Journal of Insect Physiology2001，，： | 1 |
| 15 | Health variables and gill morphology in the tropical fish Astyanaxfaseiatus from a sewage-contaminated river 显示文摘 | ALBERTO A CAMARGO A F M VERANI J R | 2005 | Ecotoxicology and Environmental Safety2005，61，2： | 1 |
| 16 | The EEG in lacunar stroke显示文摘 | Alberto P Elisabetta F Paola R | 1984 | Stroke1984，15，3： | 1 |
| 17 | Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice显示文摘 | Alberto F Alexandro R Sergio O | 2003 | Vaccine2003，21，： | 1 |
| 18 | Microporous hollow fibres for carbon dioxiode absorption: mass transfer model fitting and the supplying of carbon dioxide to microalgal cultures显示文摘 | Helena L F Alberto R | 1998 | J Chem Technol Biotechnol1998，71，： | 1 |
| 19 | Insect midgut a-mannosidases from family 38 and 47 with emphasis on those of Tenebrio molitor显示文摘 | Nathalia R Moreira Christiane Cardoso Alberto F Ribeirob | 2015 | Insect Biochemistry and Molecular Biology2015，，： | 1 |
| 20 | Protective effect of a nake DNA vaccine cocktail against lethal toxoplasmosis in mice 显示文摘 | Alberto F Alexandro R Sergio O | 2003 | Vaccine2003，21，1314： | 1 |
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