|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression显示文摘AIM: To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression.METHODS: We measured the cytokine levels of Th1 (IL-2 and IL-2R), Th2 (IL-10) and the pro-inflammatory cytokines (IL-6 and IL-6R and TNF and TNF-RⅠ and Ⅱ)by the ELISA technique in the sera of 33 hepatocellular carcinoma (HCC) patients and 20 chronic liver disease (CLD) patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus(HCV) markers served as controls.RESULTS: Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases.On the other hand, HCV viremia was detected using RTPCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases.Also bilharzial-Ab was positive in 55% of HCC cases,65% of CLD cases and in 70% of asymptomatic carriers (ASC). HCC patients had significantly higher values of IL-2R, TNF-RⅡ (P<0.001), and TNF-RⅠ (P>0.05), but lower TNFα (P<0.001) and IL-6 (P = 0.032) in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). CLD patients had higher IL-2R, TNF-RⅠ, and TNF-RⅡ (P<0.001) than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). IL-10 was higher (though not significantly) in HCC and CLD patients than in symptomatic carriers and non-cancer controls.CONCLUSION: Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R,TNF-RⅠ, and TNF-RⅡ could be used as potential markers. | Abdel-Rahman N Zekri Mohammed S El-Din Ashour Ahmed Hassan Hanaa M Alam El-Din Amal MR El-Shehaby Maha A Abu-Shady | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Kalirin inhibition of inducible nitric-oxide synthase显示文摘 | Ratovitski EA Alam MR Quick RA | 1999 | J Biol Chem1999，274，2： | 1 |
| 3 | Mitochondrial Ca2+ uptake 1(MICU1) and mitochondrial Ca2+ uniporter(MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells显示文摘 | Alam MR Groschner LN Parichatikanond W | | 0，，41： | 1 |
| 4 | Is malnutritiona risk factor of stroke? 显示文摘 | Habib MA Dey SK Alam MR Bhuiyan M | 2015 | Mymensingh Med J2015，24，2： | 1 |
| 5 | Biomarkers for identifying the early phases of osteoarthritis secondary to medial patel ar luxation in dogs显示文摘 | Alam MR Ji JR Kim MS | | 0，，03： | 1 |
| 6 | Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotidcs 显示文摘 | Juliano R Alam MR Dixit V | 2008 | Nucleic Acids Res2008，36，12： | 1 |
| 7 | Primary health care:what is it and what is it not views of teaching faculty at an undergr aduate medical college in Pakistan显示文摘 | Abbas SM Alam Malik MR | 2012 | East em Me diterranean Health Journal2012，18，3： | 1 |
| 8 | Transport properties of hydroxide and proton conducting membranes显示文摘 | Hibbs MR Hickner MA Alam TM | 2008 | Chem Mater2008，20，7： | 1 |
| 9 | Heteroresistance to vancomycin in enterococcus faecium 显示文摘 | Alam MR Susan D | 2001 | J Clin Microb2001，39，9： | 1 |
| 10 | Cyclophilin D and myocardial ischemia- reperfusion injury :A fresh perspective显示文摘 | Alam MR Baetz D Ovize M | 2015 | J Mol Cell Cardiol2015，78，： | 1 |
| 11 | Mechanisms and strategies for effective delivery of antisense and siRNA oligonucle- otides显示文摘 | JULIANO R ALAM MR DIXIT V | 2008 | Nucleic Acids Res2008，36，12： | 1 |
| 12 | Studyingmitochondrial Ca2+uptake-a revisit显示文摘 | Jean-Quartier J Bondarenko AI Alam MR | 2012 | Mol CellEndocrinol2012，353，12： | 1 |
| 13 | Biomarkers for identifying the early phases of osteoarthritis secondary to medial patel ar luxation in dogs显示文摘 | Alam MR Ji JR Kim MS | | 0，，03： | 1 |
| 14 | The endocannabi- noid N-arachidonoyl glycine (NAGIy) inhibits store-operated Ca^2 + entry by preventing STIM1-Orail interaction 显示文摘 | Deak AT Groschner LN Alam MR | 2013 | J Cell Sei2013，126，4： | 1 |
| 15 | An isoform of kalirin, a brain- specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction显示文摘 | Penzes P Johnson RC Alam MR | 2000 | J Biol Chem2000，275，： | 1 |
| 16 | Methyl prednisolone plus chlorambucil as compared with prednisolone alone for the treatment of idiopathic membranous nephropathy A preliminary study显示文摘 | Ahmed S Rahman M Alam MR | | 0，，13： | 1 |
| 17 | Synthesis and characterization of laser ablated TiNi films显示文摘 | Kumar A Alam MR Weimer J J | 1999 | Journal of Applied Physics1999，69，： | 1 |
| 18 | An isoform of kalirin,a brain-specific GDP/GTP exchange factor,is enriched in the postsynaptic density fraction显示文摘 | Penzes P Johnson RC Alam MR | 2000 | J Biol Chem2000，275，9： | 1 |
| 19 | Kalirin inhibition of inducible nitric-oxide synthase显示文摘 | Ratovitski EA Alam MR Quick RA | 1999 | J Biol C hem1999，274，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员