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| 1 | Th17 plasticity and its changes associated with inflammatory bowel disease显示文摘CD4 T helper(Th) cell differentiation into distinct T cell subsets is critical to the normal function of the immune system. Until recently,the paradigm held that na?ve T cells differentiated into distinct subsets under the guidance of environmental cues(e.g.,cytokines) and that once polarized,these cells were committed to a particular functional state. However,the existence of transdifferentiated T cell populations,which express signature transcription factors and cytokines associated with more than one Th subset,challenges the immutability of T helper subsets and suggests that plasticity is a feature of multifaceted immune responses. How this process impacts immune dysregulation in diseases such as inflammatory bowel diseases(IBD) and the machinery that underlies this process is far from fully understood. Interleukin(IL)-17 secreting helper T(Th17) cells have been heavily implicated in tissue-specific immune pathology including murine models of IBD,human Crohn's disease and ulcerative colitis. Plasticity within this subset is suggested by the existence of IL-17 secreting cells,which,can also secrete interferon-γ,the signature cytokine for Th1 cells or,can co-express the anti-inflammatory transcription factor forkhead box p3,a signature transcription factor of regulatory T cells. In this review we mainly discuss evidence for Th17 plasticity,mechanisms,which govern it,and highlight the potential to therapeutically target this process in human IBD. | Aito Ueno Abhisek Ghosh Daniel Hung Ji Li Humberto Jijon | 2015 | World Journal of Gastroenterology2015，21，43： | 23 |
| 2 | 浅层包气带水汽昼夜运移规律及其数值模拟研究显示文摘西北干旱、半干旱地区,浅层包气带水分通量主要由水汽组成,而水汽在运移过程中产生的能量转换和质量迁移是地表质能平衡计算不可缺少的重要源汇项。在野外进行一个沙坑实验,发现土壤水在中午(12:00~15:00)达到最大值(10cm深度,5.9~6.1cm^3/cm^3;30cm深度,11.9~13.1cm^3/cm^3),而在凌晨(02:00~05:00)出现最小值(10cm深度,4.4~4.5cm^3/cm^3;30cm深度,10.4~10.8cm^3/cm^3)。为进一步验证该实验条件下的土壤水运移及分布规律,考虑了土壤水、汽、热耦合运移的HYDRUS-ID模型被用来对实验过程进行模拟,模拟结果与实测结果吻合较好。为描述土壤水分昼夜运移模式,笔者将土壤水耦合运移的时间信息和空间信息进行同步分析;并根据土壤水运移的不同驱动力,分别对温度梯度、基质势梯度作用下的液态水及汽态水通量进行了分析。 | 曾亦键 万力 苏中波 Hirotaka aito 王旭升 曹文炳 | 2008 | 地学前缘2008，15，5： | 17 |
| 3 | Expression of endothelin receptor subtypes and their messenge RNAs in diabetic rat prorate:effect of insulin treatment显示文摘 | aito M Wada Y Ikeda K | 2000 | Mol cell Biochem2000，210，： | 1 |
| 4 | Ascending myelopathy in the early stage of spinal cord injury显示文摘 | Aito S El Masry WS Gerner H J | 1999 | Spinal Cord1999，37，9： | 1 |
| 5 | Primary prevention of deep venous thrombosis and pulmonary embolism in acute spinal cord in- jured patients显示文摘 | Aito S Pieri A D'Andrea M | 2002 | Spinal Cord2002，40，6： | 1 |
| 6 | Safety evaluation of proanthoyanidin rich extract from grape seeds显示文摘 | AITO M KATAOKA S | 2002 | Food and Chemical Toxicology2002，，5： | 1 |
| 7 | Production of ultra-fine grained bulk aluminum alloys by accumulative roll-bonding (ARB) process 显示文摘 | S aito Y Tsuji N Utsunomiya H | 1998 | Aluminum Alloys1998，，3： | 1 |
| 8 | Positive treatment of estradiol in postpartum psychosis显示文摘 | Ahokas A Aito M Rimon R | 2000 | J Clin Psychiatry2000，61，3： | 1 |
| 9 | Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic l7beta-estradiol:a preliminary study显示文摘 | Ahokas A Kaukoranta J Wshlbeck K Aito M | 2001 | J Clin Psychiatry2001，62，5： | 1 |
| 10 | Preparation of orally disintegrating tablets with taste-masking function: masking effect in granules prepared with correctives using the dry granulation method and evaluation of tablets prepared using the taste-masked granules 显示文摘 | Kawano Y AIto M Sasatsu | 2010 | Yakugaku Zasshi2010，130，1： | 1 |
| 11 | Analysis of the genetic loci involved in cool tolerance of a cool tolerance stain Hokkai PL5显示文摘 | Kato A Kiuchi H Aito K | 1997 | Japan J Breed1997，，2： | 1 |
| 12 | Neurological and func- tional outcome in traumatic central cord syndrome 显示文摘 | Aito S D' Andrea M Werhagen L | 2007 | Spinal Cord2007，45，4： | 1 |
| 13 | Ventilatory and respiratory muscle response to hypercapnia in patients with paraplegia显示文摘 | Gorini M Corrado A Aito S | 2000 | Am J Respir Crit Care Med2000，162，： | 1 |
| 14 | Biphasic ATP depletion caused by transient oxidative exposure is associated with apoptotic cell death in rat embryonal cortical neurons显示文摘 | Aalto KT Raivio KO | 2002 | Pediatr Res2002，52，： | 1 |
| 15 | Sequential changes of energy charge,Lipoerox ide level and DNA synthesis rate of the liver following biliary obstructive in rats显示文摘 | Kom ura M CH ijiina K N aito T | 1996 | J Surg Res1996，61，2： | 1 |
| 16 | Ventilatory and respiratory muscle response to hypercapnia in patients with paraplegia显示文摘 | Gorini M Con'ado A Aito S | 2000 | Am J Respir Crit Care Med2000，162，： | 1 |
| 17 | Lactate inhibits germ cell apoptosis in the human testis显示文摘 | Aito H Aalto K | 2002 | Mol Hum Reprod2002，8，2： | 1 |
| 18 | CompLications during the acute phase of traumatic spinal cord lesions显示文摘 | Aito S Gruppo Italiano Studio Epidemiologico Mielolesioni GISEM Group | 2003 | Spinal Cord2003，41，11： | 1 |
| 19 | Endogenous risk factors for deep-vein thrombosis in patients with acute spinal cord injuries显示文摘 | Aito S Abbate R Marcucci R | 2007 | Spinal Cord2007，45，9： | 1 |
| 20 | Association between oestradiol and puerperal psychosis 显示文摘 | Ahokas A Aito M Turianinen S | 2000 | Acta Psychiatr Scand2000，101，： | 1 |
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