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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1),in pheochromocytomas显示文摘 | Aguiar R C Cox G Pomeroy S L | 2001 | J Clin Endocrinol Metab2001，86，6： | 1 |
| 3 | A systems approach for the estimation of the effects of land consolidation projects (LCPs) :a model and its application 显示文摘 | CASTRO C J AGUIAR P P MIRA D S L | 2001 | Agricultural Systems2001，68，3： | 1 |
| 4 | Short-Term Load Forecasting for Microgrids Based on Artificial Neural Networks显示文摘 | HERNANDEZ L BALADRON C AGUIAR J M | 2013 | Energies2013，6，3： | 1 |
| 5 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
| 6 | Internal suture technique for improving projection and stability in secondary gluteoplasty显示文摘 | JAIMOVICH C A ALMEIDA M W AGUIAR L F | 2010 | Aesthet Surg J2010，30，3： | 1 |
| 7 | Microwave Promoted Suzuki Reactions between Aroyl Chlorides and Boronic Acids Catalyzed by Het- erogeneous and Homogeneous Phosphine-free Palla- dium Catalysts 显示文摘 | DANIELA DE L M AGUIAR L C ANTUNES O A | 2011 | J of Organomet Chem2011，696，1516： | 1 |
| 8 | Chemical modification of cross-linked resinbased on acrylonitrile for anchoring metal ions 显示文摘 | de Santa Maria L C Amorim M C V Aguiar M R M P | 2001 | Reactive and Functional Polymers2001，49，2： | 1 |
| 9 | Botanical origin and chemical composition of Brazilia propolis显示文摘 | Park Y K Alencar S M Aguiar C L | 2002 | Journal of Agricultural and Food Chemistry2002，50，9： | 1 |
| 10 | Cre-lox P-based system for removal and reuse of selection markers in Ashbya gossypii targeted engineering显示文摘 | AGUIAR T Q DINIS C DOMINGUES L | 2014 | Fungal Genet Biol2014，，68： | 1 |
| 11 | Changes in isoflavone profiles of soybean treated with gamma irradiation 显示文摘 | Aguiar C L Baptista A S Walder J M | 2009 | Int J Food Sci Nutr2009，60，5： | 1 |
| 12 | Performance,di- gestibility,microbial production and carcass characteristics of feedlot young bulls fed diets containing propolis显示文摘 | Aguiar S C Zeoula L M Moura L P P | 2012 | Acta Sei- entiarum-Animal Sciences2012，34，4： | 1 |
| 13 | Prokaryotes in salt marsh sediments of Ria de Aveiro: effects of halophyte vegetation on abundance and diversity显示文摘 | Oliveira V Santos A L Aguiar C | 2012 | Esmarine Coastal and Shelf Sci- ence2012，110，： | 1 |
| 14 | Effects of simulated acid rain on the foliar micromorphology and anatomy of tree tropical species显示文摘 | Sant'Anna-Santos B F Silva L C Azevedo A A Araujo J M Aires E F Silva E A M Aguiar R | 2006 | Enviromental and Exprimental Botany2006，58，13： | 1 |
| 15 | Chemical modification of cross-linked resin based on acrylonitrile for anchoring metal ions 显示文摘 | De Santa Maria L C Amorim M C V Aguiar M R M P | 2001 | React Funct Polym2001，49，2： | 1 |
| 16 | Modulation of defen- sive responses and anxiety-like behaviors by group I metabotropic glu- tamate receptors located in the dorsolateral periaqueductal gray 显示文摘 | Lima V C Molchanov M L Aguiar D C | 2008 | Prog Neuropsychopharmacol Biol Psychiatry2008，32，1： | 1 |
| 17 | Plant use and niche overlap between the introduced honey bee (Apis mellif- era) and the native bumblebee (Bombus atratus) (Hymenoptera: Apidae) in an area of Tropical Mountain Vegetation in Northeastern Brazil 显示文摘 | Franco E L Aguiar C M L Ferreira V S | 2009 | Sociohiology2009，53，1： | 1 |
| 18 | 14th international congress on antiphospholipid antibodies: Task force report on antiphospholipid syndrome treatment trends 显示文摘 | Erkan D Aguiar C L Andrade D | 2014 | Autoimmun Rev2014，13，6： | 1 |
| 19 | Podcasts in Higher Education:Students' and Lectures' Perspectives显示文摘 | Carvalho A A Aguiar C Santos H Oliveira L Marques A | | 0，，： | 1 |
| 20 | A systems approach for the estimation of the effects of land consolidation projects (LCPs): A model and its application显示文摘 | Castro C J Aguiar P P Mira S L | 2001 | Agricultural Systems2001，68，3： | 1 |
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