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| 1 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 2 | A novel recombinant virus- like particle vaccine for prevention of porcine parvovirus-in- duced reproductive failure显示文摘 | Adriaan F G Christianne J M | 2006 | Vaccine2006，24，26： | 1 |
| 3 | A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-indueed reproductive failure显示文摘 | ADRIAAN F G CHRISTIANNE J M PALOMA R | 2006 | Vaccine2006，24，24： | 1 |
| 4 | A novel recombinan!virus--like particle vaccine for prevention of porcine parvovirus-induced reproductlve failure显示文摘 | ADRIAAN F( A CHRIS FIANNE Jm B PAl OMA R et a1 | | 0，，： | 1 |
| 5 | GP5+/6+ PCR followed by reverse line blot analysis enables rapid and high throughput identification of human papillomavirus genotypes显示文摘 | Adriaan J C B Rene P Nathalie F D | 2002 | J Clin Microbiol2002，40，3： | 1 |
| 6 | The surface Laplacian of the potential: Theory and application 显示文摘 | Oostendorp T F van Oostemm Adriaan | 1996 | IEEE Trans Biomed Eng1996，43，4： | 1 |
| 7 | A novel re eombinant virus-like particle vaccine for prevention of porcine parvovirus induced reproductive failure 显示文摘 | ADRIAAN F CHRISTINE J PALOMA R | 2006 | Vaccine2006，24，24： | 1 |
| 8 | Catalytic enantioselective reformatsky reaction with ortho-substituted diarylketones显示文摘 | M Angeles F I Beatriz M Adriaan J M | 2008 | Org Lett2008，10，： | 1 |
| 9 | New definitions on reference material显示文摘 | Hendrik E Ales F Adriaan MHvan der Veen | 2006 | Accreditation and Quality Assurance2006，10，10： | 1 |
| 10 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 11 | A continuous culture study of the bioenergetic aspects of growth and production of exocellular protease in Bacillus licheniformis显示文摘 | JURJEN F HENK W V ADRIAAN H S | 1985 | Appl Microbiol Biotechnol1985，22，： | 1 |
| 12 | The clinical relevance of human papillomavirus testing: relationship between analytical and clinical sensitivity显示文摘 | Peter J F Adriaan J C Chris J L | 2003 | J Pathol2003，201，： | 1 |
| 13 | A novel recombinanl virus - llke particle vaccine for prevention of porcine parvovirus - induced reproductive failure 显示文摘 | ADRIAAN F G A CHRISTIANNE J M B PALOMA R | 2006 | Vaccine2006，245，： | 1 |
| 14 | Depression and cardiac mortality: Results from a community-based longitudinal study显示文摘 | PENNIX B W BEEKMAN AARTJAN T F HONIG ADRIAAN MD | 2001 | Arch Gen Psychiatry2001，58，3： | 1 |
| 15 | A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-indueed reproductive failure显示文摘 | Adriaan F Christine J Paloma R | 2006 | Vaccine2006，24，24： | 1 |
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