|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 2 | Salt tolerance of the annual halophyte Cakile maritima as affected by the provenance and the developmental stage显示文摘 | Megdiche W Ahmed N B Debez A Hessini K Ksouri R Zuily-Fodil Y Abdelly C | 2007 | Acta Physiologiae Plantarum2007，29，4： | 1 |
| 3 | Effects of salt on lipid peroxidation and antioxidant enzyme activities of Catharanthus roseus suspension cells 显示文摘 | Elkahoui S Hernandez J A Abdelly C | 2005 | Plant Sci- ence2005，168，3： | 1 |
| 4 | Effect of salinity on root-nodule conductance to the oxygen diffusion in the (Medicago truncat- ula) - (Sinorhizobium rneliloti) symbiosis显示文摘 | Aydi S Drevon J J Abdelly C | 2004 | Plant Physiology and Biochemistry2004，42，10： | 1 |
| 5 | NADPH oxidase-dependent HzO2, production is required for salt-induced antioxidant defense in Arabidopsisthalitma显示文摘 | Rejeb K B Benzarti M Debez A Bailly C Savour6 A Abdelly C | 2015 | Journal of Plant Physiology2015，174，174： | 1 |
| 6 | Effect of salinity on root nodule conductance to the oxygen diffusion in the Medicago truncatula-Sinorhizobium meliloti symbiosis 显示文摘 | AYDI S DREVON J J ABDELLY C | 2004 | Plant Physiology & Biochemistry2004，42，10： | 1 |
| 7 | Comparative salt tolerance analysis between Arabidopsis thaliana and Thellungiella halophila,with special emphasis on K+/Na+ selectivity and proline accumulation显示文摘 | Ghars M A Parre E Debez A Bordenave M Richard L Leport L Bouchereau A Savouré A Abdelly C | | 0，，： | 1 |
| 8 | Potassium deficiency in plants: Effects and signaling cascades显示文摘 | Hafsi C Debez A Abdelly C | 2014 | Acta Physiologiae Plantarum2014，36，： | 1 |
| 9 | Salt impact on photosynthesis and leaf ultrastructure of Aeluropus littoralis显示文摘 | BARHOUMI Z DJEBALI W CHAIBI W ABDELLY C SMAOUI A | 2007 | Journal of Plant Research2007，120，： | 1 |
| 10 | Salt tolerance in Sesuvium portu- lacastrum显示文摘 | MESSEDDI D SLEIMI N ABDELLY C | 2001 | Plant nutrition-food security and sustainability of agro-eco- systems2001，92，6： | 1 |
| 11 | Potassium deficiency in plants: effects and signaling cascades 显示文摘 | HAFSI C DEBEZ A ABDELLY C | 2014 | Acta Physiologiae Plantarum2014，36，： | 1 |
| 12 | Effects of salt on lipid peroxidation and antioxidant enzyme activities of catharanthus roseus suspension cells显示文摘 | Elkahoui S Hernandez J A Abdelly C | 2005 | Plant Science2005，，168： | 1 |
| 13 | Response of antioxidant systems to NaCl stress in the halophyte caklie maritime显示文摘 | Amor N B Jiménez A Megdiche W Lundqvist M Sevilla F Abdelly C | 2006 | Physiol Plant2006，126，： | 1 |
| 14 | Contribution of NaCl excretion to salt resistance of Aeluropuslittoralis(Willd)Parl显示文摘 | Barhoumi Z Djebali W Smaoui A Chaibi W Abdelly C | 2007 | Plant Physiology2007，164，7： | 1 |
| 15 | Optimization of ultrasound-assisted extraction of antioxidant compounds from Tunisian Zizyphus lotus fruits using response surface methodology显示文摘 | HAMMI K M JDEY A ABDELLY C | 2015 | Food chemistry2015，184，1： | 1 |
| 16 | Salt tolerance of the annual halophyte Cakile maritima as affected by the provenance and the developmental stage显示文摘 | Megdiche W Amor N B Debez A Hessini K Ksouri R Zuily-Fodil Y Abdelly C | 2007 | Acta Physiologiae Plantarum2007，29，4： | 1 |
| 17 | Cadmium effects on growth an mineral nutrition of two halophytes:Sesuvium portulacastrum and Mesembryanthemum crystallinum 显示文摘 | GHANYA T MESSEDI D ABDELLY C | 2005 | Journal of plant physiology2005，162，： | 1 |
| 18 | Effect of salt treatment on phenolic compounds and antioxidant activity of two Mesembryanthemum edule provenances显示文摘 | Falleh H Jalleli I Ksouri R Boulaaba M Guyot S Magne C Abdelly C | 2012 | Plant Physiology and Biochemistry2012，52，： | 1 |
| 19 | Effects of salt on lipidperoxidation and antioxidant enzyme activities of Catharanthus roseussuspension cells显示文摘 | Elkahoui S Hernandez J A Abdelly C | 2005 | Plant Science2005，168，： | 1 |
| 20 | Potassium deficiency in plants: effects and signaling cascades 显示文摘 | HAFSI C DEBEZ A ABDELLY C | 2014 | Acta Physiol Plant2014，36，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员