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| 1 | Modeling of fiber bridging in fluid flow for well stimulation applications显示文摘Accurate acid placement constitutes a major concern in matrix stimulation because the acid tends to penetrate the zones of least resistance while leaving the low-permeability regions of the formation untreated.Degradable materials(fibers and solid particles)have recently shown a good capability as fluid diversion to overcome the issues related to matrix stimulation.Despite the success achieved in the recent acid stimulation jobs stemming from the use of some products that rely on fiber flocculation as the main diverting mechanism,it was observed that the volume of the base fluid and the loading of the particles are not optimized.The current industry lacks a scientific design guideline because the used methodology is based on experience or empirical studies in a particular area with a particular product.It is important then to understand the fundamentals of how acid diversion works in carbonates with different diverting mechanisms and diverters.Mathematical modeling and computer simulations are effective tools to develop this understanding and are efficiently applied to new product development,new applications of existing products or usage optimization.In this work,we develop a numerical model to study fiber dynamics in fluid flow.We employ a discrete element method in which the fibers are represented by multi-rigid-body systems of interconnected spheres.The discrete fiber model is coupled with a fluid flow solver to account for the inherent simultaneous interactions.The focus of the study is on the tendency for fibers to flocculate and bridge when interacting with suspending fluids and encountering restrictions that can be representative of fractures or wormholes in carbonates.The trends of the dynamic fiber behavior under various operating conditions including fiber loading,flow rate and fluid viscosity obtained from the numerical model show consistency with experimental observations.The present numerical investigation reveals that the bridging capability of the fiber–fluid system can be enhanced by increasing the fiber loading,selecting fibers with higher stiffness,reducing the injection flow rate,reducing the suspending fluid viscosity or increasing the attractive cohesive forces among fibers by using sticky fibers. | Mehdi Ghommem Mustapha Abbad Gallyam Aidagulov Steve Dyer Dominic Brady | 2020 | Petroleum Science2020，17，3： | 4 |
| 2 | Breaking seed dormancy in Cupressus atlantica Gaussen,an endemicand threatened coniferous tree in Morocco显示文摘Cupressus atlantica Gaussen (Cupressaceae) is an endemic and endangered coniferous tree geographically restricted to the N’Fis valley in South-Western Morocco. Like many forest species, C. atlantica exhibits dormancy which delays and reduces germination. To improveseed germination, different pre-treatments were conducted on C.atlantica seeds after storage for different periods (one, two and five years) including: scarification with sandy paper; soaking seeds in hot distilled water at 60℃and 80℃for 15 min and soaking seeds for 48 h in agibberellic acid (GA3) at 1,000 and 2,000 mg·L-1. Results showed that scarification with sandy paper increased the germination rate of Atlas cypress by up to 67%, indicating that the species possess essentially anexogenous dormancy (physical dormancy) due to the hard seed coat(hardseededness). Exogenous application of gibberellic acid (GA3) at1,000 mg·L-1 was also effective in breaking seed dormancy and germination induction. These two treatments induced faster speed germination expressed by low number of days to first germination (8 10days) and low values of mean germination times (MGT). However,germination rate, under any treatment, is greatly dependent on the year of seed collection. Seeds collected in year 2004 gave the highest value,suggesting that even after five years of storage, the germination capacity of C. atlantica seeds could remain high. This observation is very interesting in the exsitu conservation of such endemic and endangered species where the production of seeds is irregular over the years. | Sfairi Youssef Ouahmane Lahcen Abbad Abdelaziz | 2012 | Journal of Forestry Research2012，23，3： | 3 |
| 3 | Cellular based treatment modalities for unresectable hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary malignancy of the liver and is unfortunately associated with an overall poor prognosis and high mortality.Early and intermediate stages of HCC allow for treatment with surgical resection,ablation and even liver transplantation,however disease progression warrants conventional systemic therapy.For years treatment options were limited to molecular-targeting medications,of which sorafenib remains the standard of care.The recent development and success of immune checkpoint inhibitors has proven to be a breakthrough in the treatment of HCC,but there is an urgent need for the development of further novel therapeutic treatments that prolong overall survival and minimize recurrence.Current investigation is focused on adoptive cell therapy including chimeric antigen receptor-T cells(CAR-T cells),T cell receptor(TCR)engineered T cells,dendritic cells,natural killer cells,and tumor infiltrating lymphocyte cells,which have shown remarkable success in the treatment of hematological and solid tumor malignancies.In this review we briefly introduce readers to the currently approved systemic treatment options and present clinical and experimental evidence of HCC immunotherapeutic treatments that will hopefully one day allow for revolutionary change in the treatment modalities used for unresectable HCC.We also provide an up-to-date compilation of ongoing clinical trials investigating CAR-T cells,TCR engineered T cells,cancer vaccines and oncolytic viruses,while discussing strategies that can help overcome commonly faced challenges when utilizing cellular based treatments. | Konstantinos Damiris Hamza Abbad Nikolaos Pyrsopoulos | 2021 | World Journal of Clinical Oncology2021，12，5： | 2 |
| 4 | Assessmem of the cost associated with wind generation prediction errors in a liberalized electricity market显示文摘 | Fabbri A Roman T G S Abbad J R | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 5 | A sociodemographic, clini cal study of patients with venous ulcer显示文摘 | Abbade LP Lastoria S Rollo HD | 2005 | International Journal of Dermatology2005，44，12： | 1 |
| 6 | Regulatory framework and business models for charging plug-in electric vehicles: Infrastructure, agents, and commercial relationships 显示文摘 | Gomez San Romdn T Mombern 1 Revier Abbad M | 2011 | Energy policy2011，39，： | 1 |
| 7 | Microporous material显示文摘 | Abbad B Attou M Kessler H | 1998 | Journal of Catalysis1998，21，1： | 1 |
| 8 | Comparative relation ship of the flag leaf and the ear photosynthesis with the bio mass and grain yield of durum wheat under a range of water conditions and different ecotypes显示文摘 | Abbad H El Jaafari S A Bort J | 2004 | Agronomic2004，24，： | 1 |
| 9 | Automatic nonhyperbolic velocity analysis显示文摘 | Brahim Abbad Bjorn Ursin Didier Rappin | 2009 | Geophysics2009，74，2： | 1 |
| 10 | Severe persistent pulmonary hypertension of the new born in a setting where limited resources exclude the use of inhaled nitric oxide: successful treatment with sildenafil 显示文摘 | Juliana AE Abbad FC | 2005 | Eur J Pediatr2005，164，10： | 1 |
| 11 | Assessment af energy distri- bution losses for increasing penetration of distributed generation显示文摘 | Quezada V H M Abbad J R Rom'an T G S | 2006 | IEEE Transactions on Power Systems2006，21，2： | 1 |
| 12 | Glycerol dehydratase activity:the limiting step for 1,3-propanediol production by Clostridium butyricum 显示文摘 | Abbad Andaloussi S Guedon E Spiesser E | 1996 | Microbiol1996，22，： | 1 |
| 13 | European Balancing Act显示文摘 | ACKERMAN T ABBAD J R DUDURYCH I M | | 0，，06： | 1 |
| 14 | Synthesis of the silicoalu- minophosshate molecular sieve SAPO-31 in the presence of fluoride ions and its characterization 显示文摘 | Abbad B Attou M Kessler H | 1998 | Microporous and Mesoporous Materials1998，21，1： | 1 |
| 15 | Cell-penetrating peptides for cancer-targeting therapy and imaging显示文摘 | Wang W Q Abbad S Zhang Z H | 2015 | Curr Cancer Drug Targets2015，15，： | 1 |
| 16 | Regulatory framework and business models for charging plug-in electric vehi- cles: Infrastructure, agents, and commercial relationships 显示文摘 | ROMAN T G S MOMBER I ABBAD M R | 2011 | Ener- gy Policy2011，39，10： | 1 |
| 17 | Diagnostic validity of helical CT compared to ultrasonography in renal-ureteral colic显示文摘 | Rcngifo Abbad D Rodriguez Caravaca G Barreales Tolosa L | 2010 | Arch Esp Urol2010，63，2： | 1 |
| 18 | Diagnostic validity of helical CT compared to uhrasonography in renal-ureteral colic 显示文摘 | Rengifo Abbad D Rodriguez Caravaca G Barreales Tolosa L | 2010 | Arch Esp Urol2010，63，2： | 1 |
| 19 | Isolation and characterization of exocellular polysaccharides produced by Bifidobacterium longum显示文摘 | ABBAD A S TALBAOUI H MARZACK R | 1995 | Applied Microbiology and Biotechnology1995，43，6： | 1 |
| 20 | Experimental and numerical characterization of honeycomb sandwich composite panels 显示文摘 | ABBAD! A KOUTSAWA Y CARMASOL A BELOUETTAR S AZARI Z | 2009 | Simulation Modelling Practice and Theory2009，17，10： | 1 |
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