| 3 | 吡嗪酰胺对结核病人利福平动力学的影响显示文摘利福平和吡嗪酰胺,与INH、链霉素或乙胺丁醇一道,构成了对结核病治疗中所提倡的药物方案中的一个重要部分。国际防痨和肺病联合会业已建议采用这两个药物作为结核病短程化学治疗的一部分。因此,本研究承担起评价两药同时给予时,吡嗪酰胺对利福平动力学的影响。 在一项随机化的、交迭法的、单一剂量的研究中,未经治疗的16名肺结核病人,经过过夜的禁食后,给予利福平450mg+INH 300mg(研究A组)或利福平450mg+INH300mg+吡嗪酰胺1500mg(研究B组)。为检测血清中利福平于0.5、2、4、6、和8小时进行血样采集。各种药物动力学的参数(利福平的Cmax、Tmax、t1/2、Kel、血浆浓度-时间曲线下的面积(AUC)、Vd和Cpl)均予以计算。 已经观察到,研究A组利福平的浓度于6小时(P<0.01)、8小时(P<0.05),与研究B组相反,明显地较高,而于0.5、2和4小时的血清中利福平浓度没有显著差异。AUC和Cpl也有显著差异。与研究B组相比,研究A组的AUC较高(P<0.05),而Cpl较低(P<0.02)。 从以上数据可见,在用利福平治疗的病人中合并给予吡嗪酰胺,利福平的AUC减少,而它的廓清率增加。 | A.Jain V.L.Mehta S.Kulshrestha 张崇贤 | 1996 | 国际结核病与肺部疾病杂志1996，0，3： | 0 |
| 4 | Competition between axial anomaly and ferromagnetic ordering in Bi_(2-x)Fe_(x)Se_(3-x)S_(x) topological insulator:A study of magnetic and magnetotransport properties显示文摘The topological insulators Bi_(2-x)Fe_(x)Se_(3-x)S_(x) have been investigated by the dc-magnetization,magnetotransport and angle resolved photoemission spectroscopy(ARPES)techniques.With doping of Fe and S,a negative giant magneto-resistance(MR)is observed for parallel electric and magnetic fields(H||E).The MR behavior at lower magnetic field can be explained with the semi-classical theory whereas the MR behavior at higher field has been attributed to the axial anomaly.Interestingly,the system reached to the quantum limit at low magnetic field(~4.5T).The magnetic ordering can be explained with the presence of both the RKKY(surface)and van-Vleck(bulk)interaction.The ARPES study reveals that a surface gap is suppressed when the magnetic ordering changes from ferromagnetic to anti-ferromagnetic ordering.The ARPES study and the appearance of quantum oscillations(SdH)in the resistivity pattern reveal that the topological surface property is preserved with the co-doping of Fe and S. | Rahul Singh Shiv Kumar A.Jain Mahima Singh Labanya Ghosh A.Singh Soma Banik A.Lakhani S.Patil E.F.Schwier K.Shimada S.M.Yusuf Sandip Chatterjee | 2022 | Journal of Materiomics2022，8，3： | 0 |
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